A5075178127- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Adhesion Molecules Research
- Urticaria and Related Conditions
- T-cell and B-cell Immunology
- Otitis Media and Relapsing Polychondritis
- Acne and Rosacea Treatments and Effects
- Chronic Kidney Disease and Diabetes
- Chemotherapy-related skin toxicity
- IgG4-Related and Inflammatory Diseases
- Renal and Vascular Pathologies
- Inflammasome and immune disorders
- Leprosy Research and Treatment
- Systemic Sclerosis and Related Diseases
- CAR-T cell therapy research
Charité - Universitätsmedizin Berlin
2018-2025
Max Delbrück Center
2020-2025
Humboldt-Universität zu Berlin
2021-2025
Freie Universität Berlin
2021-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are life-threatening systemic autoimmune diseases manifesting in the kidneys as necrotizing crescentic glomerulonephritis (NCGN). ANCA antigens myeloperoxidase (MPO) or proteinase 3. Current treatments include steroids, cytotoxic drugs and B cell-depleting antibodies. The use of chimeric antigen receptor (CAR) T cells is a promising new therapeutic approach. We tested hypothesis that CAR targeting CD19 deplete...
Significance Statement Early identification of patients at risk renal flares in ANCA vasculitis is crucial. However, current clinical parameters have limitations predicting relapse accurately. This study investigated the use urinary CD4 + T lymphocytes as a predictive biomarker for vasculitis. study, including urine samples from 102 patients, found that presence cells was robust predictor within 6-month time frame, with sensitivity 60% and specificity 97.8%. The diagnostic accuracy exceeded...
Anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) represents a group of systemic autoimmune small vessel vasculitis, leading to significant morbidity and mortality due extensive organ damage (including kidney failure)1 treatment toxicity medications such as glucocorticoids.2 Thus, research focuses on developing that minimize glucocorticoid use.
Objectives Myeloid cell activation by antineutrophil cytoplasmic antibody (ANCA) is pivotal for necrotising vasculitis, including crescentic glomerulonephritis (NCGN). In contrast to neutrophils, the contribution of classical monocyte (CM) and non-classical (NCM) remains poorly defined. We tested hypothesis that CMs contribute antibody-associated vasculitis (AAV) colony-stimulating factor-2 (CSF2, granulocyte-macrophage factor (GM-CSF)) an important monocyte-directed disease modifier....
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are systemic autoimmune diseases featuring small blood vessel inflammation and organ damage, including necrotizing crescentic glomerulonephritis (NCGN). Persistent vascular leads to endothelial kidney cell necrosis. Ferroptosis is a regulated death pathway executed by reactive oxygen species iron-dependent lipid peroxidation culminating in membrane rupture. Here we show that ANCA-activated neutrophils induced (EC) vitro...
Necrotizing crescentic glomerulonephritis is a major contributor to morbidity and mortality in Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). Because therapy relies on immunosuppressive agents with potentially severe adverse effects, reliable noninvasive biomarker of disease activity needed guide treatment.We used flow cytometry quantify T cell subsets blood urine samples from 95 patients AAV 8 controls evaluate their characteristics. These were compared soluble...
Background: ANCA-associated vasculitis (AAV) causes necrotizing crescentic glomerulonephritis (NCGN) which is a major contributor to morbidity and mortality in AAV. Since therapy relies on cytotoxic agents with potentially severe adverse effects, reliable non-invasive biomarker of disease activity needed determine the right balance between over- undertreatment. Using urine space as window into local inflammatory milieu kidney, quantification urinary leukocytes using flow cytometry has become...
EOSINOPHILIC FASCIITIS: ROLE OF CYSTATIN C with a polyclonal antibody against cystatin revealed strong positive reaction of fibrocytes/fibroblasts in areas inflammation within the fascia, and mild focal subjacent muscle fibers. Conclusion:In both patients elevated levels were obviously related to increased production rather than reduced renal function.The increase level correlation disease course is striking most likely reflects extensive involvement EF.So far, we cannot distinguish if...