A5004021060- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Autoimmune Bullous Skin Diseases
- COVID-19 and healthcare impacts
- Dialysis and Renal Disease Management
- Signaling Pathways in Disease
- Sarcoidosis and Beryllium Toxicity Research
- Otitis Media and Relapsing Polychondritis
- Atherosclerosis and Cardiovascular Diseases
- Receptor Mechanisms and Signaling
- Ocular Diseases and Behçet’s Syndrome
- Platelet Disorders and Treatments
- Urticaria and Related Conditions
- Whipple's Disease and Interleukins
- Genetic Associations and Epidemiology
- Ion Channels and Receptors
University College London
2017-2024
The Royal Free Hospital
2017-2024
Royal Free London NHS Foundation Trust
2021-2022
Roland Hill (United Kingdom)
2022
Schott (Germany)
2021
St. James's Hospital
2019
Trinity College Dublin
2019
Imperial College Healthcare NHS Trust
2018-2019
Centre for Sight
2019
National Health Service
2018
Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults, mediated by glomerular antibody deposition to an increasing number newly recognised antigens. Previous case reports have suggested association between patients with anti-contactin-1 (CNTN1)-mediated neuropathies and MGN. In observational study we investigated the pathobiology extent this potential MGN examining antibodies against CNTN1 clinical features cohort 468 suspected immune-mediated neuropathies,...
Significance Statement Myeloperoxidase released after neutrophil and monocyte activation can generate reactive oxygen species, leading to tissue damage. Free myeloperoxidase is deposited in glomeruli various forms of crescentic GN elevated ANCA-associated GN. The authors evaluated renal biopsy samples studied the effect a novel inhibitor, AZM198, vivo vitro . They demonstrate that mediates degranulation extracellular trap formation contributes ANCA-mediated endothelial Their findings...
Abstract Increased extracellular sodium activates Th17 cells, which provide protection from bacterial and fungal infections. Whilst high salt diets have been shown to worsen autoimmune disease, the immunological consequences of clinical depletion are unknown. Here, we investigate immunity in patients with inherited salt-losing tubulopathies (SLT). Forty-seven genotyped SLT (with Bartter, Gitelman or EAST Syndromes) recruited. Clinical features dysregulated recorded a standardised...
COVID-19 is a novel infectious disease with broad spectrum of clinical severity. Patients systemic vasculitis have an increased risk serious infections and may be at severe outcomes following COVID-19. We undertook this study to establish the factors for in these patients, including impact immunosuppressive therapies.A multicenter cohort was developed through participation centers affiliated national UK Ireland registries. Clinical characteristics are described. Logistic regression used...
Patients receiving in-center hemodialysis treatment face unique challenges during the coronavirus disease 2019 (COVID-19) pandemic, specifically need to attend for that prevents self-isolation. Dialysis unit attributes and isolation strategies might reduce dialysis center COVID-19 infection rates have not been previously examined.We explored role of variables, including community burden, (size layout), control strategies, on among patients in London, United Kingdom, between March 2, 2020 May...
The pandemic of coronavirus disease (COVID-19) has highly affected patients with comorbidities and frailty who cannot self-isolate, such as individuals undergoing haemodialysis. aim the study was to identify risk factors for mortality hospitalisation, which may be useful in future spikes.
Abstract Neutrophils play essential anti-microbial and inflammatory roles in host defense, however, their activities require tight regulation as dysfunction often leads to detrimental autoimmune diseases. Here we show that the adhesion molecule GPR97 allosterically activates CD177-associated membrane proteinase 3 (mPR3), conjugation with several protein interaction partners neutrophil activation humans. Crystallographic deletion analysis of extracellular region identified two independent...
Granulomatosis with polyangiitis (GPA) and microscopic (MPA) are autoimmune vasculitides associated antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils monocytes. Granulomas exclusively in GPA form around multinucleated giant cells (MGCs), at sites of microabscesses, containing apoptotic necrotic neutrophils. Since patients have augmented neutrophil PR3 expression, PR3-expressing frustrate macrophage phagocytosis cellular...
Objective. To determine the incidence of arterial thrombotic events (ATE) and venous thromboembolism (VTE) in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Methods. This is a retrospective cohort study presenting ATE (coronary or ischemic stroke) VTE [pulmonary embolism (PE) deep thrombosis (DVT)] patients diagnosed with AAV between 2005 2014. Results. There were 204 who identified. Median followup for surviving was 5.8 (range 1–10) years, accounting 1088 person-years...
ABSTRACT Background Hemodialysis patients are at high risk of Covid-19, though vaccination has significant efficacy in preventing and reducing the severity infection. Little information is available on disease vaccine since dissemination Omicron variant. Methods In a multi-center study, during period epidemic driven by variant, all hemodialysis positive for SARS-CoV-2 were identified. Outcomes analyzed according to predictor variables including status. Risk infection was using Cox...
A term neonate with a transient form of Behçet's disease (BD) is described. The mother had 3-year history BD treated corticosteroids, which remained in remission during pregnancy. On day 1 life, the was noted to have papulopustular lesions labia and perineum. She clinically well bacterial viral infection screens were negative. disappeared within 3 weeks without scarring. No recurrence has been reported.
Anti−glomerular basement membrane (anti-GBM) disease presents with rapidly progressive glomerulonephritis, often associated alveolar hemorrhage and characterized histologically by crescentic glomerulonephritis. Typically, there is linear deposition of Ig along the glomerular (GBM), which, in majority cases, due to IgG autoantibodies directed against noncollagenous domain α3 chain type IV collagen (α3[IV]NC1).1
Objective. Antineutrophil cytoplasmic antibodies (ANCA)–associated vasculitis (AAV) has been linked with thyroid disease as a result of antithyroid medications. We assessed the prevalence in our patients AAV. Methods. Clinical records 279 AAV diagnosed between 1991 and 2014 were analyzed. Results. Thyroid was identified 21.5% patients, but only 2 had previously received propylthiouracil. There greater proportion female antimyeloperoxidase antibodies, renal group disease. Conclusion. Our data...
Background: There is an established association between acquired inflammatory demyelinating neuropathies and nephrotic syndrome, but a common immunopathological mechanism has yet to be determined. Antibodies known glomerular podocyte antigens occur in up 90% of patients with syndrome due idiopathic membranous glomerulonephritis (MGN), the majority targeting phospholipase A2 receptor (PLA2R). In immune-mediated neuropathies, antibodies molecules node Ranvier, such as contactin-1 (CNTN1), are...
Objectives The use of rituximab (MabThera®), an anti-CD20 monoclonal antibody, is the most significant development in management anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) since introduction cytotoxic therapy 1950. Truxima® first biosimilar approved for same indications, and has been available UK 2017. Significant cost savings have reported when switching to biosimilars, which could lead greater patient access such treatment. Therefore, it important know whether...
A 37-year-old woman presented with a 2-week history of persistent headache in an occipitotemporal distribution. The patient had experienced prior headaches and migraines, but this presentation was characterised by its intensity duration. There associated dizziness blurring vision episodes occurring up to 4–5 times per day. Whole body cross-sectional CT imaging MRI neuronal axes were normal. Cerebrospinal fluid cytology demonstrated large abnormal pleomorphic cells expressing the tumour...
Abstract Introduction Focal segmental glomerulosclerosis (FSGS) is a significant cause of chronic kidney disease and triggered by podocyte damage which can result in cytoskeletal alterations leading to foot process effacement. Vincristine chemoprotective drug alters microtubules has been used clinically reverse FSGS. However, the mechanisms underlying beneficial effect vincristine are not understood. Methods We exposed immortalised human podocytes serum obtained from an FSGS patient before,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)