A5072212312- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Pituitary Gland Disorders and Treatments
- Connective tissue disorders research
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac, Anesthesia and Surgical Outcomes
- Adrenal and Paraganglionic Tumors
- Clinical practice guidelines implementation
- Ethics in Clinical Research
- Cardiac and Coronary Surgery Techniques
- Acute Kidney Injury Research
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Aortic Disease and Treatment Approaches
- Renin-Angiotensin System Studies
- Neurological Complications and Syndromes
- Liver physiology and pathology
- Meta-analysis and systematic reviews
- Liver Diseases and Immunity
- Diabetes Treatment and Management
- SARS-CoV-2 detection and testing
- Pregnancy and Medication Impact
University of Baghdad
2025
Imperial College London
2023-2024
Imperial College Healthcare NHS Trust
2013-2023
Hammersmith Hospital
2017-2023
National Health Service
2023
United Nations Industrial Development Organization
2017
Royal London Hospital
2015
Barts Health NHS Trust
2012-2014
Queen Mary University of London
2008-2013
Universidade de Santiago de Compostela
2009
Context: Mutations have been identified in the aryl hydrocarbon receptor-interacting protein (AIP) gene familial isolated pituitary adenomas (FIPA). It is not clear, however, how this molecular chaperone involved tumorigenesis. Objective: AIP sequence changes and expression were studied FIPA sporadic adenomas. The function of normal mutated molecules was on cell proliferation protein-protein interaction. Cellular ultrastructural localization determined cells. Patients: Twenty-six kindreds 85...
Thrombotic microangiopathies (TMAs) are frequently difficult to differentiate clinically, and measurement of ADAMTS13 (a disintegrin metalloproteinase with a thrombospondin type 1 motif, member 13) remains vital in thrombotic thrombocytopenic purpura (TTP) diagnosis. We retrospectively reviewed cases referred for testing, using UK TTP Registry screening data. Of total 810 cases, 350 were confirmed as TTP. The 460 non-TTP comprised secondary TMAs (24·57%) haemolytic uraemic syndrome (HUS)...
This study explores the semiotic aspects of American slang, specifically focusing on phenomenon reduplicative expressions in informal speech. Despite extensive research limited attention has been given to cultural and mythical meanings embedded within expressions. To address this gap, investigates how these convey denotative, connotative, casual discourse. The objectives include: 1. what extent does Barthes’ model hold potential for application study? 2. How are slang widely used everyday...
De novo HLA donor-specific antibodies (DSA) following transplantation are associated with alloimmune injury and allograft failure. Blood transfusions allogeneic, when given posttransplant (PTBT) they may independently increase the risk of antibody development. This study aims to analyze development transfusion-specific (TSA) blood donors examine impact on clinical outcomes. A total 244 received by 86 transplant patients (46 who developed a DSA post transfusion 40 remained negative) were...
ABSTRACT Background Hemodialysis patients are at high risk of Covid-19, though vaccination has significant efficacy in preventing and reducing the severity infection. Little information is available on disease vaccine since dissemination Omicron variant. Methods In a multi-center study, during period epidemic driven by variant, all hemodialysis positive for SARS-CoV-2 were identified. Outcomes analyzed according to predictor variables including status. Risk infection was using Cox...
Diabetes mellitus (DM) and renal impairment (RI) are both independent predictors of mortality after coronary artery bypass graft surgery (CABG). The two conditions often coexist, yet the impact on long-term prognosis CABG each factor relative to other in combination is uncertain.We undertook a prospective cohort study 4869 patients who underwent between 2003 2007. was divided into four groups according preoperative diabetic status function: without either DM or RI (reference group), with...
Whether reexposure to mismatched HLA antigens (RMM) in the setting of a negative crossmatch is associated with increased immunological risk remains an area uncertainty. This due evidence derived predominantly from registry data, which lacks comprehensive information on alloantibody and rejection. In this study, we analyze impact low-level preformed donor-specific antibodies (DSA) against RMM transplant outcomes. From 1988 consecutive renal recipients, analyzed 179 patients undergoing...
In 19 children with hepatic fibrosis as the result of continued schistosomiasis mansoni and 20 without fibrosis, following studies were carried out: HLA antigen typing for 30 antigens, immune response T lymphocytes to schistosome by measuring DNA synthesis evidenced 3H-thymidine uptake, measurement total OKT3+, OKT4+, OKT8+ cells using monoclonal antibodies. Patients mostly high responders in contrast those fibrosis. High susceptibility post-schistosomal associated a frequency A2 B12...
Patient Blood Management (PBM), endorsed by the World Health Organisation is an evidence-based, multi-disciplinary approach to minimise inappropriate blood product transfusions. Kidney transplantation presents a particular challenge PBM, as comprehensive evidence of risk transfusion lacking. The aim this study investigate prevalence post-transplant transfusions across multiple centres, analyse factors for and compare transplant outcomes status.This analysis was co-ordinated via UK Transplant...
<h3>Introduction</h3> Contrast induced nephropathy (CIN) is associated with adverse clinical outcomes, including prolonged hospitalisation and increased morbidity mortality following elective invasive cardiac procedures. The impact of CIN primary PCI (PPCI) for ST segment elevation MI (STEMI) remains poorly defined. <h3>Aim</h3> To investigate the long-term prognostic implications PPCI STEMI. <h3>Methods</h3> This a retrospective observational registry study. Data were available upon 2224...
Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations the transforming growth factor beta (TGFβ) receptor genes TGFBR1 TGFBR2. Mean age at 26.1 years, most often due to dissection. We report an unusually late presentation LDS, diagnosed following elective...
<h3>Aims</h3> Previous research has demonstrated that patients with diabetes mellitus (DM) have a worse prognosis than without following coronary artery bypass graft surgery (CABG). However, insulin treated (ITD) may different when compared non-insulin diabetic (NITD) after CABG. There is limited data investigating long term outcomes CABG in ITD and NITD patients. This study at 5 years these two patient groups. <h3>Methods</h3> 7442 consecutive underwent single cardiac centre between 2003...
Meeting Reports/Abstracts| January 21 2009 AIP, a Protein Mutated in Familial Acromegaly, Plays Role the Regulation of Cell Proliferation and Shows Cell-Type Specific Subcellular Localisation Subject Area: Endocrinology , Women's Children's Health C.A. Leontiou; Leontiou aEndocrinology, Search for other works by this author on: This Site PubMed Google Scholar M. Gueorguiev; Gueorguiev S. Hassan; Hassan J. van der Spuy; Spuy cCardiac, Vascular & Inflammation Research, Barts London Medical...