A5041047645- Receptor Mechanisms and Signaling
- Immune Response and Inflammation
- Signaling Pathways in Disease
- Blood disorders and treatments
- S100 Proteins and Annexins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Chang Gung University
2018-2022
Abstract Neutrophils play essential anti-microbial and inflammatory roles in host defense, however, their activities require tight regulation as dysfunction often leads to detrimental autoimmune diseases. Here we show that the adhesion molecule GPR97 allosterically activates CD177-associated membrane proteinase 3 (mPR3), conjugation with several protein interaction partners neutrophil activation humans. Crystallographic deletion analysis of extracellular region identified two independent...
The adhesion family of G protein-coupled receptors (aGPCRs) comprises 33 members in human, several which are distinctly expressed and functionally involved polymorphonuclear cells (PMNs). As former work indicated the possible presence aGPCR GPR97 granulocytes, we studied its cellular distribution, molecular structure, signal transduction, biological function PMNs. RNA sequencing mass-spectrometry revealed abundant protein expression ADGRG3/GPR97 granulocyte precursors terminally...
Abstract Neutrophils play essential anti-microbial and inflammatory roles in host defense, however their activities are tightly regulated as neutrophil dysfunction often leads to detrimental autoimmune diseases. Here, we identified a novel PR3/CD177/GPR97/PAR2/CD16b interactome critical modulator of activation. Using multiple approaches, deorphanized GPR97, human neutrophil-restricted adhesion G protein-coupled receptor (aGPCR), the interacting protein allosteric activator CD177-associated...