A5028282491- Tuberous Sclerosis Complex Research
- Organ Transplantation Techniques and Outcomes
- Healthcare Policy and Management
- PI3K/AKT/mTOR signaling in cancer
- Polyomavirus and related diseases
- Geriatric Care and Nursing Homes
- Transplantation: Methods and Outcomes
- Lymphatic System and Diseases
- Proteoglycans and glycosaminoglycans research
- Neonatal Respiratory Health Research
- Mast cells and histamine
- Elder Abuse and Neglect
- Kruppel-like factors research
- Congenital heart defects research
- Wnt/β-catenin signaling in development and cancer
- Vascular Tumors and Angiosarcomas
- Health disparities and outcomes
Boston University
2024
Brigham and Women's Hospital
2019-2022
Harvard University
2019-2022
Medicaid is the largest health insurance program in United States, covering more than 86 million Americans as of early 2023, and key for progress towards equity. Although policy changes like expansion have significantly expanded number people who are eligible Medicaid, administrative burdens enrolling renewing coverage can be substantial. many applications now submitted online, physical access to offices still plays a critical role understanding eligibility, getting help applying, navigating...
Lymphatic vessels play an important role in health and disease. In this study, we evaluated the effects of GSK3-β inhibition on lung lymphatic endothelial cells vitro. Pharmacological silencing resulted increased lymphangiogenesis cells. To investigate mechanisms GSK3-β-mediated lymphangiogenesis, interrogated mammalian/mechanistic target rapamycin pathway found that PTEN activation subsequent decreased AKT, leading to p-P70S6kinase levels, indicating mTOR pathway. addition, consistent with...
Abstract Hyaluronan (HA) is associated with innate immune response activation and may be a marker of allograft dysfunction in lung transplant recipients. This was prospective, single center study comparing levels bronchioalveolar lavage (BAL) serum HA the immobilizer LYVE-1 recipients without acute cellular rejection (ACR). Chronic (CLAD)-free survival also evaluated based on levels. 78 were enrolled total 115 diagnostic biopsies 1.5 years median follow-up. Serum correlated BAL (r = 0.25, p...
Lung allograft rejection results in the accumulation of low-molecular weight hyaluronic acid (LMW-HA), which further propagates inflammation and tissue injury. We have previously shown that therapeutic lymphangiogenesis a murine model lung reduced LMW-HA was associated with improved transplant outcomes. Herein, we investigated use 4-Methylumbelliferone (4MU), known inhibitor HA synthesis, to alleviate acute transplantation. found treating mice 4MU from days 20 30 after sufficient...
Abstract Background Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least part through hyaluronan drainage. Lymphatic vessel endothelial receptor (LYVE-1) expressed on the surface of lymphatic cells plays important roles uptake. The impact current immunosuppressive therapies largely unknown. We tested hypothesis FK506, most commonly used immunosuppressant after transplantation, induces cell...
Lymphangioleiomyomatosis (LAM) is a rare progressive disease, characterized by mutations in the tuberous sclerosis complex genes ( TSC1 or TSC2 ) and hyperactivation of mechanistic target rapamycin 1 (mTORC1). Here, we report that E26 transformation–specific (ETS) variant transcription factor 2 (ETV2) critical regulator Tsc2 -deficient cell survival. ETV2 nuclear localization cells mTORC1-independent enhanced spleen tyrosine kinase (Syk) inhibition. In nucleus, transcriptionally regulates...
Abstract Lymphangioleiomyomatosis (LAM) is a rare progressive disease, characterized by mutations in the tuberous sclerosis complex genes ( Tsc1 or Tsc2 ), and hyperactivation of mechanistic target rapamycin 1 (mTORC1). The effectiveness mTORC1 inhibitors limited their lack cytotoxic effects. Here, we report that E26 transformation specific (ETS) Variant Transcription Factor 2 (ETV2) critical regulator Tsc2-deficient cell survival. Nuclear localization ETV2 cells mTORC1-independent enhanced...