A5046210764- Photoreceptor and optogenetics research
- Light effects on plants
- Photosynthetic Processes and Mechanisms
- Plant and Biological Electrophysiology Studies
- Algal biology and biofuel production
- Circadian rhythm and melatonin
- Protist diversity and phylogeny
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Vehicle Routing Optimization Methods
- Organoboron and organosilicon chemistry
- Analytical Chemistry and Sensors
- Constraint Satisfaction and Optimization
- Multi-Criteria Decision Making
- Plant Stress Responses and Tolerance
- Genetic Neurodegenerative Diseases
- Marine and coastal ecosystems
- Optical Imaging and Spectroscopy Techniques
- Plant Molecular Biology Research
- Mass Spectrometry Techniques and Applications
- Molecular Communication and Nanonetworks
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Scheduling and Timetabling Solutions
Jawaharlal Nehru University
2021-2024
University of Georgia
2024
Bridge University
2023
University of Delhi
1999-2020
Nagoya Institute of Technology
2020
Council of Scientific and Industrial Research
1997
We explored how the number of structures is determined in an intracellular organelle series. In Tetrahymena, oral apparatus contains three diagonal ciliary rows: M1, M2, and M3. During development, M rows emerge by sequential segmentation a group basal bodies, starting with longest most anterior M1 ending shortest posterior The mpD-1 mpH-1 alleles increase decrease rows, respectively. identify MpH as TPR protein MpD importin-9. Both proteins localize to form concentration gradients. row...
Several neurodegenerative diseases are caused by expansion of polyglutamine repeats in the affected proteins. In spino‐cerebellar ataxia type 1 (SCA1), histidine interruptions have been reported to mitigate pathological effects long glutamine stretches. To understand this phenomenon, we investigated conformational preferences peptides containing both uninterrupted stretches and those with interruption(s) as seen SCA1 normals. Our study suggests that substitution histidines glutamines induces...
Abstract Channelrhodopsins (ChRs) are light-gated ion channels extensively applied as optogenetics tools for manipulating neuronal activity. All currently known ChRs comprise a large cytoplasmic domain, whose function is elusive. Here, we report the cation channel properties of KnChR, one photoreceptors from filamentous terrestrial alga Klebsormidium nitens , and demonstrate that domain KnChR modulates properties. constituted 7-transmembrane forming pore, followed by C-terminus moiety...
Rhodopsins have been extensively employed for optogenetic regulation of bioelectrical activity excitable cells and other cellular processes across biological systems. Various strategies adopted to attune the at desired subcellular compartment (plasma membrane, endoplasmic reticulum, Golgi, mitochondria, lysosome) within cell. These include- adding signal sequences, tethering peptides, specific interaction sites, or mRNA elements different sites in proteins plasma membrane integration...
Phototropin (Phot), a blue light‐sensing LOV domain protein, mediates light responses and is evolutionarily conserved across the green lineage. Klebsormidium nitens , terrestrial alga, presents valuable opportunity to study adaptive from aquatic land habitat transitions. We determined crystal structure of Phot LOV1 (KnLOV1) in dark engineered different mutations (R60K, Q122N, D33N) modulate lifetime photorecovery cycle. observed unusual, slow recovery kinetics wild‐type KnLOV1 (τ = 41 ± 3...
Abstract Phototropin, a blue-light sensing serine/threonine kinase, plays pivotal role in regulating diverse photophysiological processes both plants and algae. In Chlamydomonas reinhardtii , phototropin (CrPhot) localizes to the eyespot flagella, coordinating key cellular functions such as phototaxis, photosynthesis, gametogenesis, chlorophyll biosynthesis. While previous research has identified interactions with signaling proteins channelrhodopsins light-harvesting complex proteins, many...
Abstract Phototropin (Phot), a blue light sensing LOV domain protein, mediates responses and is evolutionary conserved across the green lineage. Klebsormidium nitens, terrestrial alga, presents valuable opportunity in studying adaptive from aquatic to land habitat transitions. We determined crystal structure of nitens Phot LOV1 (KnLOV1) dark engineered different mutations (R60K, Q122N, D33N) modulate lifetime photo recovery cycle. observed an unusual slow native KnLOV1 (τ = 2467 seconds)...
Objectives: An algorithm has been developed to find Pareto Optimal solutions of the fuzzy bicriteria sheet metal problem with pairwise nesting designs. Methods and Statistical Analysis: The solved by many workers, all whom have considered entities cost time as crisp numbers. However, in practical situations since are imprecise, present work considers them interval Ordering between overlapping numbers is obtained applying a membership approach modified Hungarian obtain problem. newly...
An algorithm has been developed to find feasible solution of the time table assignment problem faculty. A 0-1 linear programming model in developed, considering priorities teacher and workload. This process assigning tasks by developing a finding is difficult because its size various conflicting objectives problem. Use LINGO18 MATHEMATICA 9 softwares have made achieve desired results.
Abstract Channelrhodopsins are a family of microbial rhodopsins that function as light-gated ion channel. We report the molecular properties novel channelrhodopsin KnRh3 from an evolutionary important filamentous terrestrial alga Klebsormidium nitens. is constituted 7-transmembrane domain, followed by long C-terminus moiety encodes peptidoglycan binding domain (FimV). When functionally expressed in mammalian cells, showed light-induced cation channel currents. The maximum action spectrum...