A5024472506- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Polymer Surface Interaction Studies
- 3D Printing in Biomedical Research
- Fuel Cells and Related Materials
- Advancements in Solid Oxide Fuel Cells
- Electrocatalysts for Energy Conversion
- Extracellular vesicles in disease
- Silk-based biomaterials and applications
- Marine Biology and Environmental Chemistry
- Polymer composites and self-healing
- Magnesium Oxide Properties and Applications
- Advanced biosensing and bioanalysis techniques
- Magnesium Alloys: Properties and Applications
- Orthopaedic implants and arthroplasty
- Collagen: Extraction and Characterization
- Advanced Drug Delivery Systems
- Dental Implant Techniques and Outcomes
- Photoreceptor and optogenetics research
- Carbon dioxide utilization in catalysis
- Circular RNAs in diseases
- Dermatologic Treatments and Research
- Surgical Sutures and Adhesives
- Viral Infectious Diseases and Gene Expression in Insects
CHA University
2021-2022
RIKEN Center for Emergent Matter Science
2019-2021
Tokyo Institute of Technology
2021
Gyeonggi Research Institute
2021
Chung-Ang University
2012-2016
University of Tsukuba
2015-2016
University of Florida
2016
American Institute of Aeronautics and Astronautics
2016
University of Michigan
2016
Exosomes derived from mesenchymal stem cells (MSCs) have been studied as vital components of regenerative medicine. Typically, various isolation methods exosomes cell culture medium developed to increase the yield exosomes. Moreover, exosome-depletion process serum has considered result in clinically active and highly purified medium. Our aim was compare methods, ultracentrifuge (UC)-based conventional method, tangential flow filtration (TFF) system-based method for separation with high...
Current approaches of biomaterials for the repair critical-sized bone defects still require immense effort to overcome numerous obstacles. The biodegradable polymer-based scaffolds have been required expand further function tissue engineering. Poly(lactic-co-glycolic) acid (PLGA) is one most common biopolymers owing its biodegradability regenerations. However, there are major clinical challenges that byproducts PLGA cause an acidic environment implanting site. critical processes in...
Allyl-amino thioxanthone derivatives as new visible-light photoinitiators for efficient free-radical, cationic and thiol–ene polymerizations.
Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) astaxanthin (ATX), have been prepared functional dermal fillers with enhanced physicochemical biological performance. In this study, polycaprolactone (PCL)-based were produced uniform size of about 30-40 μm by utilizing membrane emulsification device. MH from the PCL/MH effectively neutralized acidic products PCL degradation. For in vitro cell experiments, when degradation...
Poly(L-lactic acid) (PLLA) has been used as a biodegradable vascular scaffold (BVS) material due to high mechanical property, biodegradability, and biocompatibility. However, acidic byproducts from hydrolysis of PLLA reduce the pH after surrounding implanted area cause inflammatory responses. As result, severe inflammation, thrombosis, in-stent restenosis can occur implantation by using BVS. Additionally, polymers such could not find on X-ray computed tomography (CT) because low radiopacity....
ABSTRACT A visible light‐curable polysaccharide conjugate was prepared and included with epidermal growth factor (EGF) for wound healing application. Alginate modified furfurylamine, the furfuryl alginate (F‐alginate) mixed Rose Bengal light reactivity. The introduction of group confirmed by 1 H‐NMR UV/vis spectroscopy. Visible light‐induced crosslinking evaluated micropatterning weight measurement. Swelling ratio also determined. To verify its applicability in applications, EGF system...
Abstract Titanium (Ti) is widely used as an implant material. There are various kinds of Ti surface modification methods to facilitate effective osseointegration. In this study, UV‐curable azido‐LMC (azidophenyl low molecular weight chitosan) was modify the surface. Here we suggest a novel coating material that confers complex, diverse improvements through simple process. First, cytotoxicity test against osteoblast MG‐63 performed. The curing ratio dependent on UV irradiation time and...
Poly(L-lactic acid) (PLLA) has attracted a great deal of attention for its use in biomedical materials such as biodegradable vascular scaffolds due to high biocompatibility. However, inherent brittleness and inflammatory responses by acidic by-products PLLA limit application materials. Magnesium hydroxide (MH) drawn potential additive since it neutralizing effect. Despite the advantages MH, MH can be easily agglomerated, resulting poor dispersion polymer matrix. To overcome this problem,...
Endothelialization by materials provides a promising approach for the rapid re-endothelialization of cardiovascular implantation. Although previous studies have focused on improving endothelialization through immobilization bioactive molecules onto surface biodegradable implants, comparative effective modification not yet been reported. Here, we conducted study poly(lactide-co-glycolide) (PLGA)-based composites to graft mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) using...
Abstract Carboxymethyl starch was modified by the incorporation of an azidophenyl group to prepare photoreactive starch, and characterized Fourier transform infrared reflectance (FT‐IR), proton nuclear magnetic resonance ( 1 H‐NMR), ultraviolet (UV) spectroscopy. Photo‐irradiation immobilized Az‐starch on a polystyrene plate it stably retained surface. The protein containing also stripe micropatterned plate. UV irradiation time concentration were used alter physical properties consequently...
Artificial materials have no biological functions, but they are important for medical devices such as artificial organs and matrices regenerative medicine. In this study, mitogenic differentiation-inducible devised via the simple coating of polypeptides, which contain sequence epidermal growth factor or insulin-like with a key amino acid (3,4-dihydroxyphenylalanine) underwater adhesive proteins. The polypeptides prepared solid-phase synthesis form layers on various substrates involving...
In vitro selection has been widely used to generate molecular-recognition elements in analytical sciences. Although reconstituted types of transcription and translation (IVTT) system, such as PURE are nowadays for ribosome display mRNA/cDNA display, use E. coli extract is often avoided, presumably because it contains unfavorable contaminants, ribonuclease. Nevertheless, the initial speed protein markedly faster than that system. We thus hypothesized more appropriate instant Here, we first...
For thermo-responsive self-healing polymers with an intrinsic system, the Diels-Alder (DA) reaction is one of most promising mechanisms since it highly efficient, simple, and repeatable only application heat.Two new approaches regards to DA are developed improve current polymers.First, by using maleimide furan moieties as healing agents, that use force from shape memory effect close two crack surfaces instead external forces.Secondly, introducing anthracene moieties, increased cleaving...