A5101555200- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Organoboron and organosilicon chemistry
- Carbohydrate Chemistry and Synthesis
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Peptidase Inhibition and Analysis
- Catalytic C–H Functionalization Methods
- Click Chemistry and Applications
- Chemical Synthesis and Reactions
- Radical Photochemical Reactions
- Crystallography and molecular interactions
- High-pressure geophysics and materials
- Topic Modeling
- Dust and Plasma Wave Phenomena
- Metal and Thin Film Mechanics
- Microbial Natural Products and Biosynthesis
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- Natural Language Processing Techniques
- Glycosylation and Glycoproteins Research
- Advanced NMR Techniques and Applications
Chinese Academy of Sciences
2010-2024
Sichuan University
2012-2024
State Key Laboratory of Biotherapy
2013-2024
Chengdu Institute of Biology
2010-2024
Chongqing University of Arts and Sciences
2012-2016
Institute of Fluid Physics
2012
University of Chinese Academy of Sciences
2010
Abstract A copper/borinic acid dual catalytic reaction enabled the enantioselective propargylation of aliphatic polyols. Readily available reagents and catalysts were used in this transformation, which displayed good to excellent chemo‐ stereoselectivity for a broad array substrates. The method was also applicable desymmetrization meso 1,2‐diols furnish products with three stereogenic centers terminal alkyne group one operation.
We report here the use of simple and readily available alkyl sulfoxides as precursors to radicals their application in preparation pyridine derivatives. show that sulfoxides, N-methoxy pyridinium salts fluoride anions form electron donor-acceptor (EDA) complexes solution, which, upon visible light irradiation, undergo a radical chain process afford various derivatives smoothly. This reaction displays broad scope with respect both pyridiniums. The synthetic versatility handle chemistry adds...
Direct and site-selective O-arylation of carbohydrates has been a challenge in synthesis. Herein we report method based on copper-catalyzed to address this challenge. Proper choice the ancillary ligand copper is critical for efficiency site selectivity transformation. This features mild conditions, tolerates various functional groups, demonstrates broad substrate scope.
Abstract Reported is the asymmetric propargylic substitution (APS) reaction of 5 H ‐thiazol‐4‐ones using a Cu/Zn dual metal catalytic system and APS ‐oxazol‐4‐ones Cu/Ti system. These reactions furnish functional‐group‐rich, terminal‐alkyne‐containing products with two vicinal stereocenters in high yields good to excellent diastereo‐ enantioselectivities. This study demonstrates use systems as viable approach improve selectivity profiles copper‐catalyzed reactions.
Abstract We have found that readily available N ‐alkyl hydroxylamines are effective reagents for the amination of organoboronic acids in presence trichloroacetonitrile. This reaction proceeds rapidly at room temperature and absence added metal or base, it tolerates a remarkable range functional groups, can be used late‐stage assembly two complex units.
Methods to diversify indolizines are valuable for the discovery of medications and fluorescent molecules. The utilization copper-catalyzed asymmetric propargylation install a terminal alkyne handle on indolizine heterocycle is reported. This method delivers C3-propargylation products from C2-substituted or C1-propargylation C2,C3-disubstituted through stereoconvergent pathway.
The selective modification of carbohydrates is significant for producing their unnatural analogues drug discovery. C1-functionalization (glycosylation) and C1,C2-difunctionalization have been well developed. In contrast, C3-functionalization or C1,C3-difunctionalization remains rare. Herein, we report such processes that efficiently stereoselectively modify carbohydrates. Specifically, found trifluoroethanol (TFE) could promote 1,3-bis-indolylation/pyrrolylation 2-nitroglycals generated...
Abstract A copper/borinic acid dual catalytic reaction enabled the enantioselective propargylation of aliphatic polyols. Readily available reagents and catalysts were used in this transformation, which displayed good to excellent chemo‐ stereoselectivity for a broad array substrates. The method was also applicable desymmetrization meso 1,2‐diols furnish products with three stereogenic centers terminal alkyne group one operation.
Abstract We have found that readily available N ‐alkyl hydroxylamines are effective reagents for the amination of organoboronic acids in presence trichloroacetonitrile. This reaction proceeds rapidly at room temperature and absence added metal or base, it tolerates a remarkable range functional groups, can be used late‐stage assembly two complex units.
A method to prepare chiral β3-amino esters from methyl 3-aminopropanoate was described. This capitalized on a sequence involving an Ir-catalyzed asymmetric allylation of 2-azaallyl anions and 2-aza-Cope rearrangement. β3-Amino containing versatile alkene group were prepared.
Abstract Direct and site‐selective O‐arylation of carbohydrates has been a challenge in synthesis. Herein we report method based on copper‐catalyzed to address this challenge. Proper choice the ancillary ligand copper is critical for efficiency site selectivity transformation. This features mild conditions, tolerates various functional groups, demonstrates broad substrate scope.
We have developed a convenient and efficient method for the synthesis of dipeptidyl benzoxaboroles their peptidomimetics. The novel were obtained by protecting-group-free coupling 6-amino-1,3-dihydro-2,1-benzoxaborol-1-ol with various <i>N</i>-(arylcarbonyl)phenylalanines. Bioisosteric replacement terminal amide moiety 1,3,4-oxadiazoles or 4<i>H</i>-3,1-benzothiazin-4-one provided peptidomimetics good molecular diversity. These transformations based on pluripotency methyl...
Abstract The electrical conductivity of noble gas plasmas is investigated by using the relaxation‐time approximation in density range 10 –5 –10 g cm –3 and temperature 4 5 K. calculated shows reasonable consistency with shock wave experiments theoretical simulations at above 2 × K where Coulomb interaction dominates. A nonmetal to metal transition helium plasma predicted 2.4 shown agreement most recent experiment (above 1.9 ). Furthermore, insulator‐metal densities all are compared available...
Abstract We report here the use of simple and readily available alkyl sulfoxides as precursors to radicals their application in preparation pyridine derivatives. show that sulfoxides, N ‐methoxy pyridinium salts fluoride anions form electron donor–acceptor (EDA) complexes solution, which, upon visible light irradiation, undergo a radical chain process afford various derivatives smoothly. This reaction displays broad scope with respect both pyridiniums. The synthetic versatility handle...
Using a linear mixture rule in which electron–electron, electron–atom and electron–ion interactions are considered, we calculate the electrical conductivity of iron nickel plasmas from expanded fluid domain to warm dense matter regime. The plasma composition is obtained by nonideal Saha equation. A nonmetal–metal transition predicted present model takes places moderate-density region relatively lower-temperature region. effect on total evaluated average momentum transport cross-section...
Abstract Reported is the asymmetric propargylic substitution (APS) reaction of 5 H ‐thiazol‐4‐ones using a Cu/Zn dual metal catalytic system and APS ‐oxazol‐4‐ones Cu/Ti system. These reactions furnish functional‐group‐rich, terminal‐alkyne‐containing products with two vicinal stereocenters in high yields good to excellent diastereo‐ enantioselectivities. This study demonstrates use systems as viable approach improve selectivity profiles copper‐catalyzed reactions.