A5023521030- Analytical Methods in Pharmaceuticals
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Chromatography
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Antibiotics Pharmacokinetics and Efficacy
- Agricultural and Food Sciences
- Pesticide Residue Analysis and Safety
- Fungal Biology and Applications
- Environmental Sustainability and Education
- Phytochemistry Medicinal Plant Applications
- Plant-Derived Bioactive Compounds
- Heavy Metals in Plants
- Protein purification and stability
- Diabetes Treatment and Management
- Green IT and Sustainability
- Pharmaceutical studies and practices
- Geography and Environmental Studies
- Drug Solubulity and Delivery Systems
- Recycling and Waste Management Techniques
- Public Health in Brazil
- Spectroscopy and Chemometric Analyses
- Chemistry Education and Research
Universidade do Vale do Rio dos Sinos
2019
Universidade Federal do Rio Grande do Sul
2005-2015
Rabeprazole sodium is an antisecretory agent that inhibits the enzyme H+/K+ ATPase present in stomach parietal cells. There are few data about its quantitative determinations laboratorial routines. Capillary electrophoresis a method being used increasingly for analysis of pharmaceutical compounds, main advantages which simplicity instrumentation, low consumption sample and reagents, fast analysis. The aim this study was to develop validate capillary determination rabeprazole coated tablets....
Sitagliptin phosphate is a drug used to treat diabetes mellitus type 2, and it belongs new therapeutic class called dipeptidyl peptidase IV inhibitors.This hypoglycemic commercially available in coated tablets containing 25, 50, 100 mg of sitagliptin base.The purpose this study was develop validate the conditions for dissolution test by investigating possible vivo-in vitro correlation.Several parameters were tested method, following considered satisfactory: pH 6.8 buffer, 900 mL medium,...
abstract Ultraviolet spectrophotometric (UV) and Liquid Chromatographic (LC) methods for the determination of mianserin hydrochloride in pharmaceutical formulation were developed validated. The various parameters, such as specificity, linearity, precision accuracy studied according to International Conference on Harmonization (ICH, 2005). For UV method, was determinate at 278 nm using HCl 0.1 M solvent. response linear concentration range 20.0 - 140.0 µg/mL (r = 0.9998). Precision data...
A simple, stability-indicating micellar electrokinetic chromatography (MEKC) method was developed and validated for the analysis of mianserin hydrochloride in coated tablets. The employed (hydroxymethyl)aminomethane (TRIS) 50 mM to which sodium dodecyl sulfate (SDS) added at pH 10.6 as electrolyte voltage applied 25 kV. capillary used 48.5 cm long (40.0 effective length 50.0 µm i.d.) detection wavelength 220 nm. Tetracycline internal standard. accordance with International Conference on...
Tibolone is a drug used as hormonal repository and very important due to its characteristic of helping reduce the symptoms triggered by alteration during climacteric period. Although widely used, Brazilian Pharmacopoeia does not have any information about this hormone. In literature, only studies with methodologies using high performance liquid chromatography for quantification were found. Thus, study aimed develop validate analytical method UV spectrophotometry quality control in capsule...
A dissolution test for mianserin hydrochloride in coated tablets containing 30 mg was developed and validated using a fast ultraviolet spectrophotometric method. The appropriate conditions were determinate after testing sink conditions, agitation spped medium. tested showed that soluble 0.01 0.1 M hydrochloric acid (HCl), acetate buffer pH 4.1 5.0 phosphate 6.8. Then, tests performed to investigate the drug release each Optimal carry out 900 mL HCl USP apparatus 2 (paddle) at 50 rpm stirring...