A5085168992- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Veterinary medicine and infectious diseases
- Antifungal resistance and susceptibility
- Orthopedic Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Antimicrobial agents and applications
- Heat shock proteins research
- Infectious Diseases and Mycology
- Wood and Agarwood Research
- Clostridium difficile and Clostridium perfringens research
- Oral microbiology and periodontitis research
- Business Strategies and Innovation
- Botanical Studies and Applications
- Plant biochemistry and biosynthesis
- Redox biology and oxidative stress
- Health and Conflict Studies
- Polyomavirus and related diseases
- Agriculture, Plant Science, Crop Management
- Selenium in Biological Systems
- Wnt/β-catenin signaling in development and cancer
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Agricultural economics and policies
Debiopharm (Switzerland)
2023-2025
Medical University of Silesia
2024
Cardinal Stefan Wyszyński University in Warsaw
2018-2020
University Hospital of Basel
2012-2016
Biology of Infection
2014
Lund University
2010-2012
Instytut Badawczy Leśnictwa
2007
Aspergillus and Mucorales species cause severe infections in patients after hematopoietic stem cell transplantation (HSCT). Induction of antifungal CD4(+) T-helper type 1 (Th1) immunity is an appealing strategy to combat these infections. Immunotherapeutic approaches are so far limited because a lack antigens inducing protective T cells, their elaborate production, the need targeting broad spectrum pathogenic fungi.We examined response different fumigatus proteins healthy individuals HSCT...
Abstract Background Staphylococci are the most common causative pathogens in bone and joint infections (BJI). Treatment for BJI is a major clinical challenge, with recurrent persistent occurring 40% of patients. Afabicin advanced FabI inhibitor development has potential to be first microbiome-sparing anti-staphylococcal antibiotic. Currently, Phase 2 trial (NCT03723551) enrolling patients treated 3-6 weeks afabicin or standard care (SoC). Results cohort this study (2-3 treatment) presented...
Abstract Background Afabicin is a novel antimicrobial in clinical development for the treatment of staphylococcal infections. Its active moiety, afabicin desphosphono (Debio 1452), inhibits essential enoyl-ACP reductase enzyme FabI, exerting effects by disrupting fatty acid biosynthesis. Herein, we describe an assessment probability PK-PD target attainment (PTA) to support dose selection patients with bone and joint infections (BJI). Methods MICs 872 Staphylococcus aureus isolates collected...
Thioredoxin (Trx)-1 is a small, ubiquitously expressed redox-active protein with known important cytosolic functions. However, Trx1 also upregulated in response to various stress stimuli, found both at the cell surface and secreted into plasma, has anti-inflammatory antiapoptotic properties. Previous animal studies have demonstrated that exogenous delivery can therapeutic effects number of disease models implicated an interaction complement system. We form HUVEC acts as inhibitor deposition...
Multidrug-resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV-seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from CMV-seronegative donor. Experimental treatments using leflunomide artesunate failed. Re-transplantation donor supported by adoptive transfer of pp65-specific T cells maribavir was followed lasting suppression. This case illustrates that successful MDR CMV therapy may...
Treatment options are limited for implant-associated infections (IAI) that mainly caused by biofilm-forming staphylococci. We report here on the activity of serrulatane compound 8-hydroxyserrulat-14-en-19-oic acid (EN4), a diterpene isolated from Australian plant Eremophila neglecta. EN4 elicited antimicrobial toward various Gram-positive bacteria but not to Gram-negative bacteria. It showed similar bactericidal effect against logarithmic-phase, stationary-phase, and adherent Staphylococcus...
Thin polymer films that prevent the adhesion of bacteria are interest as coatings for development infection‐resistant biomaterials. This study investigates influence grafting density and film thickness on Staphylococcus epidermidis to poly(poly(ethylene glycol)methacrylate) (PPEGMA) poly(2‐hydroxyethyl methacrylate) (PHEMA) brushes prepared via surface‐initiated atom transfer radical polymerization (SI‐ATRP). These compared with poly(ethylene glycol) (PEG) brushes, which obtained by PEG onto...
Abstract Background Antibiotic use is associated with collateral damage to the healthy microbiota. Afabicin a first-in-class prodrug inhibitor of FabI enzyme that, when converted pharmacologically active agent afabicin desphosphono, demonstrates staphylococcal-specific spectrum activity. An expected benefit highly targeted antibiotics such as microbiome preservation. Objectives To compare effects oral treatment and standard-of-care upon murine gut microbiota, assess on human Methods Gut...
In the presented work, a series of 22 hybrids 8-quinolinesulfonamide and 1,4-disubstituted triazole with antiproliferative activity were designed synthesised. The title compounds using molecular modelling techniques. For this purpose, machine-learning, docking, dynamics methods used. Calculations pharmacokinetic parameters (connected absorption, distribution, metabolism, excretion, toxicity) also performed. new synthesised via copper-catalysed azide–alkyne cycloaddition reaction (CuAAC)....
Breast cancer has the highest incidence rate among all malignancies worldwide. Its high mortality is mainly related to occurrence of multidrug resistance, which significantly limits therapeutic options. In this regard, there an urgent need develop compounds that would overcome phenomenon. There are few reports in literature selenium can modulate activity P-glycoprotein (MDR1). Therefore, we performed silico studies and evaluated effects novel selenoesters EDAG-1 EDAG-8 on BCRP, MDR1, MRP1...
One of the most compelling approaches in discovery novel antimicrobials is screening natural sources. In our publication we report on activity a compound 8-hydroxyserrulat-14-en-19-oic acid (EN4), diterpene isolated from Australian plant Eremophila neglecta. We evaluate its applicability for treatment implant-associated infections. A comprehensive analysis mechanism action EN4 against staphylococci revealed membranolytic properties and general inhibition macromolecular biosynthesis, which...