A5004385448- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Metal-Catalyzed Oxygenation Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Trace Elements in Health
- Chromium effects and bioremediation
- Parasites and Host Interactions
- SARS-CoV-2 detection and testing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Vanadium and Halogenation Chemistry
- Microbial Fuel Cells and Bioremediation
Johns Hopkins University
2017-2022
Centers for Disease Control and Prevention
2021
Until recently, NADPH oxidase (NOX) enzymes were thought to be a property of multicellularity, where the reactive oxygen species (ROS) produced by NOX acts in signaling processes or attacking invading microbes through oxidative damage. We demonstrate here that unicellular yeast and opportunistic fungal pathogen Candida albicans is capable ROS burst using member enzyme family, which we identify as Fre8. C. can exist either yeast-like budding form filamentous multicellular hyphae pseudohyphae,...
Copper (Cu)-only superoxide dismutases (SOD) represent a newly characterized class of extracellular SODs important for virulence several fungal pathogens. Previous studies the Cu-only enzyme SOD5 from opportunistic pathogen Candida albicans have revealed that active-site structure and Cu binding strongly deviate those Cu/Zn-SODs in its animal hosts, making possible target future antifungal drug design. C. also expresses SOD4 is highly similar sequence to SOD5, but poorly characterized. Here,...
Key Points Patients with ESKD on dialysis had persistent and intermittently positive RT-PCR tests for severe acute respiratory syndrome coronavirus 2. Evidence presence of infectious virus was lacking in most cases. A symptom-based approach, instead a test-based should be used to decide when discontinue transmission-based precautions. Background maintenance receive common spaces other patients have higher risk SARS-CoV-2 infections. They may persistently or after infection. We describe the...
Candida auris is an emerging multidrug-resistant fungal pathogen. With high mortality rates, there urgent need for new antifungals to combat C. auris. Possible antifungal targets include Cu-only superoxide dismutases (SODs), extracellular SODs that are unique fungi and effectively the burst of host immunity. essential virulence diverse pathogens; however, little understood about these enzymes in We show here secretes enzymatically active SOD (CaurSOD4) when cells starved Fe, a condition...