A5003243629- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Surgical Simulation and Training
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Digital Imaging in Medicine
- Neuroscience and Neuropharmacology Research
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Soft Robotics and Applications
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Visual perception and processing mechanisms
- Adenosine and Purinergic Signaling
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Intraocular Surgery and Lenses
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Anatomy and Medical Technology
California Institute of Technology
2020-2023
University of California, San Francisco
2012-2019
Center for Theoretical Biological Physics
2015-2016
Stanford University
2011
Dopamine D2 receptors (D2Rs) play a major role in the function of prefrontal cortex (PFC), and may contribute to dysfunction conditions such as schizophrenia. Here we report that mouse PFC, D2Rs are selectively expressed by subtype layer V pyramidal neurons have thick apical tufts, prominent h-current, subcortical projections. Within this subpopulation, D2R agonist quinpirole elicits novel afterdepolarization generates voltage fluctuations spiking for hundreds milliseconds. Surprisingly, is...
Behavioral tasks involving auditory cues activate inhibitory neurons within cortex, leading to a reduction in the amplitude of evoked response potentials (ERPs). One hypothesis is that this process, termed “task engagement,” may enable context-dependent behaviors. Here we set out determine (1) whether medial prefrontal cortex (mPFC) plays role task engagement and (2) how relates processing male female mice performing decision-making can be guided by either or visual cues. We found that,...
The rodent visual system has attracted great interest in recent years due to its experimental tractability, but the fundamental mechanisms used by mouse represent world remain unclear. In primate, researchers have argued from both behavioral and neural evidence that a key step representation is ‘figure-ground segmentation’, delineation of figures as distinct backgrounds. To determine if mice also show signatures figure-ground segmentation, we trained on segmentation task where were defined...
Sequential patterns of prefrontal activity are believed to mediate important behaviors, e.g., working memory, but it remains unclear exactly how they generated. In accordance with previous studies cortical circuits, we found that microcircuits in young adult mice spontaneously generate many more stereotyped sequences than expected by chance. However, the key question whether these depend on a specific functional organization within microcircuit, or emerge simply as by-product random...
Abstract The rodent visual system has attracted great interest in recent years due to its experimental tractability, but the fundamental mechanisms used by mouse represent world remain unclear. In primate, researchers have argued from both behavioral and neural evidence that a key step representation is “figure-ground segmentation,” delineation of figures as distinct backgrounds [1–4]. To determine if mice also show signatures figure-ground segmentation, we trained on segmentation task where...
Our previous work classified a taxonomy of suturing gestures during vesicourethral anastomosis robotic radical prostatectomy in association with tissue tears and patient outcomes. Herein, we train deep-learning based computer vision (CV) to automate the identification classification for needle driving attempts. Using two independent raters, manually annotated live video clips label timepoints gestures. Identification (2395 videos) (511 datasets were compiled CV models produce two- five-class...