A5057279220- Cannabis and Cannabinoid Research
- Carcinogens and Genotoxicity Assessment
- TGF-β signaling in diseases
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Plant Genetic and Mutation Studies
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
Newcastle University
2022-2025
University of Bremen
2017
Brain (Germany)
2017
Cytokines of the TGF-β superfamily control essential cell fate decisions via receptor regulated SMAD (R-SMAD) transcription factors. Ligand-induced R-SMAD phosphorylation in cytosol triggers their activation and nuclear accumulation. We determine how R-SMADs are inactivated by dephosphorylation nucleus to counteract signaling ligands. show that is mediated an inner membrane associated complex containing scaffold protein MAN1 CTDNEP1-NEP1R1 phosphatase. Structural prediction, domain mapping...
Background: Studies have revealed that cancer might be treated with cannabinoids since they can influence cell survival. These findings suggest an alternative treatment option to chemo- and radiotherapy, are associated numerous adverse side-effects for the patients. Materials Methods: Viability staining was conducted on lung cancer, testicular neuroblastoma cells different concentrations of synthetic cannabinoid WIN 55,212-2 percentage dead compared. Activity apoptosis-related enzymes...
MALDI-TOF MS is a powerful analytical technique that provides fast and label-free readout for in vitro assays the high-throughput screening (HTS) environment. Here, we describe development of novel, HTS compatible, MS-based drug discovery assay endoplasmic reticulum aminopeptidase 1 (ERAP1), an important target immuno-oncology auto-immune diseases. A was developed beginning with already established ERAP1 RapidFire (RF MS) assay, where peptide YTAFTIPSI trimmed into product TAFTIPSI. We noted...