A5025053717- 3D Printing in Biomedical Research
- Angiogenesis and VEGF in Cancer
- Platelet Disorders and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Cellular Mechanics and Interactions
- Inflammatory Biomarkers in Disease Prognosis
- Blood properties and coagulation
- Electrospun Nanofibers in Biomedical Applications
- Kruppel-like factors research
- Planarian Biology and Electrostimulation
Massachusetts Institute of Technology
2023-2024
ETH Zurich
2022
Cell-laden hydrogels used in tissue engineering generally lack sufficient 3D topographical guidance for cells to mature into aligned tissues. A new strategy called filamented light (FLight) biofabrication rapidly creates composed of unidirectional microfilament networks, with diameters on the length scale single cells. Due optical modulation instability, a beam is divided optically FLight beams. Local polymerization photoactive resin triggered, leading local increase refractive index, which...
Abstract A bidirectional association exists between metastatic dissemination and the hypercoagulable state associated with many types of cancer. As such, clinical studies have provided evidence that markers elevated levels coagulation fibrinolysis correlate decreased patient survival. However, elucidating mechanisms underpinning effects different components system on metastasis formation is challenging both in animal models 2D lacking complex cellular interactions necessary to model...
Abstract Shear stress generated by the flow of blood in vasculature is a potent regulator endothelial cell phenotype and vascular structure. While responses to are complex context-dependent, signaling response shear induced laminar flows coordinated transcription factor KLF2. The expression KLF2 cells associated with quiescent, anti-inflammatory has been well characterized two-dimensional systems, but not studied three-dimensional vitro systems. Here we develop engineered microvascular...
Biofabrication In article number 2204301, Marcy Zenobi-Wong and co-workers use Filamented Light (FLight) biofabrication to create hydrogel constructs containing ultrahigh-aspect-ratio microfilaments. FLight is both fast biocompatible. Microfilaments associated microchannels provide effective topological guidance cues instruct cell migration, alignment, extracellular matrix deposition of resident cells.