A5049618880- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Inflammatory Bowel Disease
- Graphene and Nanomaterials Applications
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Photoacoustic and Ultrasonic Imaging
- Acute Lymphoblastic Leukemia research
- Radiation Therapy and Dosimetry
- Cancer Research and Treatments
- Quantum Dots Synthesis And Properties
- Nanoparticle-Based Drug Delivery
- Skin Protection and Aging
Oslo University Hospital
2013-2024
Norwegian Cancer Society
2013
Spherical carbon nanoparticles (carbon nanodots) with a silver shell were investigated as potential sensitizing agents. The cytotoxicity of the combination ultraviolet radiation or x-rays nanodots was examined in cancer cells vitro. cell viability decreased following exposure to radiation. enhanced effects by significantly reducing amount surviving compared that exposed only Carbon-core silver-shell can be proposed bimodal sensitization platform for biological and medicinal applications...
In this study, we describe a photocatalytic system based on spherical fluorescent carbon-core nanoparticles (nanodots) that can be activated with ultraviolet radiation. The carbon nanodots poly(propionylethylenimine-co-ethylenimine) coating were investigated in human prostate adenocarcinoma (Du145 and PC3) cell cultures vitro. cells become more sensitive to radiation when preincubated the nanodots. inverse slope of survival curves is about 20–30% lower for compared alone. Such...
Extracorporeal photopheresis (ECP), a modality that exposes isolated leukocytes to the photosensitizer 8-methoxypsoralen (8-MOP) and ultraviolet-A (UV-A) light, is used treat conditions such as cutaneous T-cell lymphoma graft-versus-host disease. However, current procedure of ECP has limited selectivity efficiency; produces only partial response in majority treated patients. Additionally, treatment expensive time-consuming, so improvement for this needed. In study, we concept photodynamic...
Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA), a precursor to the potent photosensitizer, protoporphyrin IX (PpIX), is an established modality for several malignant and premalignant diseases. This treatment based on light-activated PpIX in targeted lesions. Although numerous studies have confirmed necrosis apoptosis involved mechanism of action this modality, little information available change exosome levels after treatment. We report from first study effects ALA-PDT cytokines...
Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) which is the precursor of photosensitizer protoporphyrin IX (PpIX) an available treatment for several diseases. ALA-PDT induces apoptosis and necrosis target lesions. We have recently reported effects on cytokines exosomes human healthy peripheral blood mononuclear cells (PBMCs). This study has investigated ALA-PDT-mediated PBMC subsets from patients with active Crohn’s disease (CD). No lymphocyte survival after were observed,...
Background/Objectives: With the increasing prevalence of Crohn’s disease (CD), treatment op-tions for patients who fail conventional and advanced therapy are highly needed. Therefore, we explored safety efficacy extracorporeal photopheresis (ECP) using 5-aminolevulinic acid (ALA) blue light (405 nm). Methods: Patients with active CD failed or were intolerant to biological eligi-ble. Mononuclear cells (90 mL) collected from each patient a Spectra Optia® apheresis system diluted 100 mL 0.9%...
Background/Objectives: With the increasing prevalence of Crohn’s disease (CD), treatment options for patients who fail conventional and advanced therapy are highly needed. Therefore, we explored safety efficacy extracorporeal photopheresis (ECP) using 5-aminolevulinic acid (ALA) blue light (405 nm). Methods: Patients with active CD failed or were intolerant to biological eligible. Mononuclear cells (90 mL) collected from each patient a Spectra Optia® apheresis system diluted 100 mL 0.9%...
Photodynamic therapy (PDT) is a treatment strategy that utilizes photosensitizers (PSs) and light of specific wavelength to kill cancer cells. However, limited tumor specificity still drawback for the clinical application PDT. To increase therapeutic efficacy PDT, novel human minibody (MS5) recognizes cell surface receptor expressed on various cells was labeled with hydrophilic phthalocyanine PS IR700 generate an MS5-IR700 conjugate activated by near-infrared (NIR) light. The phototoxicity...