A5009384641- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Skin Protection and Aging
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Inflammatory Bowel Disease
- Ocular Oncology and Treatments
- Antimicrobial Peptides and Activities
- Oral Health Pathology and Treatment
- Ultrasound and Hyperthermia Applications
- Nonmelanoma Skin Cancer Studies
- 3D Printing in Biomedical Research
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Probiotics and Fermented Foods
- Innovative Microfluidic and Catalytic Techniques Innovation
- Polymer Nanocomposite Synthesis and Irradiation
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Bladder and Urothelial Cancer Treatments
- Cutaneous lymphoproliferative disorders research
- Salivary Gland Tumors Diagnosis and Treatment
Oslo University Hospital
2010-2024
University of Oslo
2006-2007
Abstract Purpose: The coagulation trigger tissue factor has been implicated in tumor growth, angiogenesis, and metastasis. In this study, we explore the effects of ex vivo delivery short interfering RNA (siRNA) targeting on B16 melanoma colonization lung a murine model for purposes work are to establish noncytotoxic investigation function provide preclinical assessment therapeutic potential siRNA prevention Experimental Design Results: C57BL/6 mice were evaluated pulmonary metastases...
Given their safe use in humans and inherent adjuvanticity, Lactic Acid Bacteria may offer several advantages over other mucosal delivery strategies for cancer vaccines. The objective of this study is to evaluate the immune responses mice after oral immunization with Lactobacillus (L) plantarum WCFS1 expressing a cell-wall anchored tumor antigen NY-ESO-1. And investigate immunostimulatory potency new candidate vaccine on human dendritic cells (DCs). L. displaying NY-ESO-1 induced specific...
Objectives: Urinary bladder urothelial carcinoma is diagnosed by a combination of cystoscopy and biopsy, with cytology as valuable additional technique. The accuracy cytological diagnosis depends on the experience cytologist can inevitably vary from one to another. There need for an easy, reliable objective diagnostic method. In present study new method was designed detection cancer cells in urine. Methods: Flow cytometry utilized detect protoporphyrin IX artificial model consisting normal...
Photodynamic therapy (PDT) is a non-invasive therapeutic modality based on the interaction between photosensitive molecule called photosensitizer (PS) and visible light irradiation in presence of oxygen molecule. Protoporphyrin IX (PpIX), an efficient widely used PS, hampered clinical PDT by its poor water-solubility tendency to self-aggregate. These features are strongly related PS hydrophilic-lipophilic balance. In order improve chemical properties PpIX, series amphiphilic PpIX derivatives...
Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA), a precursor to the potent photosensitizer, protoporphyrin IX (PpIX), is an established modality for several malignant and premalignant diseases. This treatment based on light-activated PpIX in targeted lesions. Although numerous studies have confirmed necrosis apoptosis involved mechanism of action this modality, little information available change exosome levels after treatment. We report from first study effects ALA-PDT cytokines...
mAbs have emerged as a promising strategy for the treatment of cancer. However, in several malignancies, no effective antitumor are yet available. Identifying therapeutic that recognize common tumor antigens could render widely applicable. Here, human single-chain variable fragment (scFv) antibody library was sequentially affinity selected against panel cancer cell lines and an (named MS5) bound to solid blood cells identified. The MS5 scFv fused IgG1 Fc domain generate (MS5-Fc fusion)...
Therapeutic strategies aiming at mobilizing immune effector cells to kill tumor independent of mutational load and MHC expression status are expected benefit cancer patients. Recently, we engineered various peptide-Fc fusion proteins for directing Fcg receptor-bearing toward cells. Here, investigated the immunostimulatory anti-tumor effects one Fc (WN-Fc). In contrast control, soluble WN-Fc-1 protein activated innate (e.g. monocytes, macrophages, dendritic cells, NK cells), resulting in...
Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) which is the precursor of photosensitizer protoporphyrin IX (PpIX) an available treatment for several diseases. ALA-PDT induces apoptosis and necrosis target lesions. We have recently reported effects on cytokines exosomes human healthy peripheral blood mononuclear cells (PBMCs). This study has investigated ALA-PDT-mediated PBMC subsets from patients with active Crohn’s disease (CD). No lymphocyte survival after were observed,...
Background/Objectives: With the increasing prevalence of Crohn’s disease (CD), treatment op-tions for patients who fail conventional and advanced therapy are highly needed. Therefore, we explored safety efficacy extracorporeal photopheresis (ECP) using 5-aminolevulinic acid (ALA) blue light (405 nm). Methods: Patients with active CD failed or were intolerant to biological eligi-ble. Mononuclear cells (90 mL) collected from each patient a Spectra Optia® apheresis system diluted 100 mL 0.9%...
Background/Objectives: With the increasing prevalence of Crohn’s disease (CD), treatment options for patients who fail conventional and advanced therapy are highly needed. Therefore, we explored safety efficacy extracorporeal photopheresis (ECP) using 5-aminolevulinic acid (ALA) blue light (405 nm). Methods: Patients with active CD failed or were intolerant to biological eligible. Mononuclear cells (90 mL) collected from each patient a Spectra Optia® apheresis system diluted 100 mL 0.9%...