Methyl 5-aminolaevulinate (mALA) is an ester derivative of 5-aminolaevulinic acid (ALA) with increased lipophilicity compared ALA.To assess long-term cure rate, cosmesis, recurrence rate and extent fibrosis after mALA-based photodynamic therapy (PDT) superficial nodular basal cell carcinomas (BCCs) showing early complete response to treatment.Of 350 BCCs treated, 310 responded completely. These were in 59 patients who followed for 2-4 years (mean 35 months) mALA-PDT. Nodular tumours curetted...

Fifty-eight patients with 119 nodular (2 mm or more in thickness) basal cell carcinomas successfully treated photodynamic therapy were included this 1-year follow-up study. The initial cure rate at 3-6 months was 92% after therapy, which an debulking procedure and topical application of dimethylsulphoxide order to enhance penetration 5-aminolevulinic acid (20% cream) the lesions exposed for 3 h prior exposure light. At examination 12-26 (mean 17 months) treatment 113 (95%) still complete...

Abstract The aim of this study was to assess the diagnostic utility thyroglobulin (Tg) in fine needle aspirates (Tg‐FNAB) nonthyroidal neck masses using a sensitive in‐house method for detecting Tg washout specimens. A total 256 samples from 145 patients were evaluated specimen FNAB and compared corresponding cytological smear histology 46 surgical measured by time‐resolved immunofluorometric assay. sensitivity Tg‐FNAB alone or combination with findings found be 100% both follow‐up group...

Background Methyl 5‐aminolaevulinate (mALA) is an ester derivative of 5‐aminolaevulinic acid (ALA) with increased lipophilicity compared ALA. Objectives To assess long‐term cure rate, cosmesis, recurrence rate and extent fibrosis after mALA‐based photodynamic therapy (PDT) superficial nodular basal cell carcinomas (BCCs) showing early complete response to treatment. Methods Of 350 BCCs treated, 310 responded completely. These were in 59 patients who followed for 2–4 years (mean 35 months)...

Summary— Between 1976 and 1985, 132 patients with T2/T3/T4a bladder cancer underwent cystectomy after pre‐operative radiotherapy (46 Gy: 67 patients; 20 65 patients). After a median time of 41 months, 62 were alive; 51 had died from recurrent 19 intercurrent disease without recurrence their malignancy. Distant metastases developed in 40 patients, accompanied 5 cases by local recurrence. Local was the first sign relapse 11 patients. In 3 localisation remained unknown. The corrected 5‐year...

Objectives: Urinary bladder urothelial carcinoma is diagnosed by a combination of cystoscopy and biopsy, with cytology as valuable additional technique. The accuracy cytological diagnosis depends on the experience cytologist can inevitably vary from one to another. There need for an easy, reliable objective diagnostic method. In present study new method was designed detection cancer cells in urine. Methods: Flow cytometry utilized detect protoporphyrin IX artificial model consisting normal...

Four different genes were identified by immunoscreening of a cDNA expression library from the human prostate cancer cell line DU145 with allogeneic sera four patients. A encoding nucleolar protein No55 was further analysed and shown to be expressed at mRNA level in several normal tissues, including ovaries, pancreas lines PC-3, PC-3m LNCaP. By reverse transcriptase/polymerase chain reaction, several-fold higher two out nine primary tumours metastatic lesions, compared tissue. Antibodies...

Objective To evaluate whether DNA ploidy and immunohistochemistry performed in primary prostatic carcinoma specimens give predictive information on regional lymph node metastasis addition to T category, histological grade serum prostate specific antigen (PSA). Patients methods Pre‐treatment TURP from 80 patients with T0‐T3/M0 disease were retrospectively evaluated by means of grade, immuno‐staining for PSA, acid phosphatase (PAP), neuron‐specific enolase (NSE) p53 protein. Pelvic dissection...

Objective To identify, in a retrospective study, possible molecular markers predictive of radioresponsiveness patients with transitional cell carcinoma (TCC) the bladder. Patients and methods T2–T4a TCC treated preoperative radiotherapy cystectomy were included study if their specimen was pT3b (in 42) or pT0 17). Because treatment schedules changed over time, given either as 2 Gy × 23 4–5 weeks later 23), 4 5 during 1 week following 36 patients). Protein expression p53, mdm2 p21 (CDKN1...

Objectives To determine the survival and investigate prognostic significance of immunohistochemical variables clinical factors in patients with hormone‐resistant prostate cancer (HRPC) symptomatic pelvic tumours, whom preliminary observations indicated that exceeded median 8–10 months HRPC painful bone metastases. Patients methods Seventy‐five referred for palliative radiotherapy between 1980 1996 were identified. For all at least two biopsies had been obtained, one before primary hormone...

Objective To detect occult regional lymph node metastases in patients with T3pN0M0 prostate cancer not recognized by routine haematoxylin and eosin staining, to evaluate the clinical relevance of this finding. Patients methods Formalin‐fixed paraffin‐embedded pelvic nodes (1118) from 92 were evaluated immunohistochemistry using antibodies for specific antigen (PSA) pancytokeratin (AE1/AE3). Of tumours, 14% well, 69% moderately 17% poorly differentiated. The extent tumour was categorized as...

Various types of mineral dust can induce interstitial pulmonary fibrosis, but there is no definite correlation between lung X‐ray findings, tissue lesions and the type dust. In this paper, we report on post mortem verification talcosis by analysis, using light microscopy, scanning electron energy dispersive x‐ray microanalysis diffractometry.

Photodynamic therapy is a new mode of cancer treatment with promising results for basal cell carcinoma. The current study aims to investigate the accuracy skin scrape cytology in diagnosis carcinoma as an integrated part procedure. A total 107 nodular carcinomas from 90 patients were examined and cytological histological diagnoses compared. Compared histopathology, cytopathology gave 3 false benign (2.8%) no malignant diagnoses. Three lesions by both methods. We conclude that reliably...

Objective To determine the natural course of incidental untreated transition zone prostate cancer and thus help to identify criteria predict prognosis treatment for individual patients. Materials methods A total 1135 unselected surgical specimens prostate, examined during 1974 1975, were reviewed while unaware case by two experienced pathologists. The patients from which samples obtained followed up 20 years or death Cancer Registry Norway outcome compared with histological review. Results...

Expression of c-erbB-2 protein, neuron-specific enolase (NSE) and DNA ploidy was studied by immunohistochemistry flow cytometry in formalin-fixed paraffin-embedded specimens from 104 patients with locally advanced transitional cell carcinoma the bladder. Positive membrane bound staining found 15% tumours, 38% tumours were positive for NSE. Only one tumour stained positively both NSE c-erbB-2. protein neither correlated to stage nor histopathological grade. The frequency non-diploid 78% 49...