A5060234506- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Computational Drug Discovery Methods
- Multicomponent Synthesis of Heterocycles
- Click Chemistry and Applications
- Inflammatory mediators and NSAID effects
- Bioactive Compounds and Antitumor Agents
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Reactions of Organic Compounds
- Synthesis of heterocyclic compounds
- Oxidative Organic Chemistry Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Quinazolinone synthesis and applications
- Synthesis of β-Lactam Compounds
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
- Chemical synthesis and pharmacological studies
- Fungal Plant Pathogen Control
- Synthesis of Organic Compounds
- Crystallography and molecular interactions
- Cancer therapeutics and mechanisms
- Free Radicals and Antioxidants
- Phenothiazines and Benzothiazines Synthesis and Activities
National Research Centre
2016-2025
Université de Bordeaux
2020-2021
Centre National de la Recherche Scientifique
2020-2021
Institut Européen de Chimie et Biologie
2020-2021
Institut Polytechnique de Bordeaux
2020-2021
IBM (Egypt)
2016-2019
A new series of quinazolinone–alkanesulfonates have been designed and synthesized as antimicrobial agents. Two derivatives exhibited potential MIC activity.
An innovative design strategy for the synthesis of benzothiazole–sulfonate conjugate 6i.
Design and synthesis of a series 5-benzylidene(thio)barbiturates
In the title molecule, C 20 H 21 N 3 O 5 S, methylideneformohydrazide and methoxybenzene groups are almost coplanar, with indolyl group being rotated farther from plane. The molecules in crystal structure form chains parallel to a- axis direction through N—H...O hydrogen-bonding interactions. Neighbouring linked by contacts a three-dimensional network.
Abstract Dementia is a cognitive disturbance that generally correlated with central nervous system diseases, especially Alzheimer's disease. The limited number of medications available insufficient to improve the lifestyle patients suffering from this Thus, new benzimidazole–thiazole hybrids ( 3–10 ) were designed and synthesized as acetylcholinesterase (AChE) butyrylcholinesterase (BChE) inhibitory agents. in vitro evaluation displayed derivatives 4b , 4d 5b 6a 7a 8b demonstrated dual...
Design and synthesis of a series hydrazone-sulfonate hybrids,
Novel, non-steroidal anti-inflammatory drug (NSAID), acetaminophen conjugates 6a–l with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some (6d, 6e, 6h, and 6k) exhibit more potent activity than their parent drugs, (b) show no visible stomach lesions in contrast to drugs which are highly ulcerogenic, (c) that bio-active compounds have mortality rates or toxic symptoms at 5 fold applied dosage. A...
Anti-oncological active spiro-alkaloids were synthesized exhibiting promising antitumor properties against melanoma cell lines. Molecular modeling studies describe the observed properties.
Abstract A series of 1″-(alkylsulfonyl)-dispiro[indoline-3,2′-pyrrolidine-3′,3″-piperidine]-2,4″-diones 6a‒o has been synthesized through regioselective multi-component azomethine dipolar cycloaddition reaction 1-(alkylsulfonyl)-3,5-bis(ylidene)-piperidin-4-ones 3a ‒ h . X-ray diffraction studies ( 6b‒d , ) confirmed the structures. The majority analogs reveal promising antiproliferation properties against a variety human cancer cell lines (MCF7, HCT116, A431 and PaCa2) with good selectivity...
Extensive research has been conducted on aspirin, a widely recognized NSAID medication, regarding its potential as an anticancer agent. Studies have revealed ability to trigger cell death in different types of cancer cells.
Abstract A new series of hydrazone derivatives incorporating spirocyclic aminopyrimidine with aryl alkanesulfonates were synthesized. The targeted products obtained in excellent yields via an acid catalyzed reaction hydrazinopyrimidine aldehyde sulfonates. structures the synthesized hydrazones studied by different spectroscopic tools, addition to high resolution mass analysis. antiproliferative activities compounds tested vitro against National Cancer Institute (NCI) 60 cell panel...
Potent antitumor active (HeLa, cervical carcinoma cell line) indole-based compounds were synthesized<italic>via</italic>azomethine ylide 1,3-dipolar cycloaddition with 3,5-arylidene-4-piperidones.
Background: A new set of hybrid conjugates derived from 2-(4-isobutylphenyl)propanoic acid (ibuprofen) is synthesized to overcome the drawbacks current non-steroidal anti-inflammatory drugs. Results & methodology: Synthesized were screened for their anti-inflammatory, analgesic and ulcerogenic properties. Few found have significant properties in carrageenan-induced rat paw edema test, while a fair number showed promising peripheral activity acetic acid-induced writhing test as well central...
4‐(1 H ‐benzo[d]imidazol‐2‐yl)thiazol‐2‐amine and its 1‐methyl derivative ( 1 ) were reacted with different reagents such as acid anhydrides, malononitrile, chloroacetyl chloride, aromatic aldehydes to produce the corresponding benzimidazole products 2 , 3 4 5 6 7 8 9 respectively. Also, 2‐chloro‐ N ‐(4‐(1‐methyl‐1 ‐benzo[d]imidazol‐2‐yl)thiazol‐2‐yl) acetamide was diaminoethane, ortho ‐substituted aniline, thioglycolic acid, thiosemicarbazide derivatives, secondary amines, potassium...
Benzotriazole and microwave mediated syntheses led to a new set of hybrid conjugates pyrazinoic acid with isoniazid via amino linkers in excellent yields retention chirality. Microbiological screening the synthesized revealed an exceptionally high activity against some pathogenic bacterial strains at low concentrations. Promising antimycobacterial properties were observed tuberculous non-tuberculous mycobacteria. Robust molecular models (2D-QSAR 3D-pharmacophore) support biological...