An anti-neoplastic fluoro-substituted dispiro-oxindole is described along with theoretical studies and single crystal X-ray analysis.

DFT studies of an anti-proliferative active spiro-oxindole against diverse tumor cell lines were reported.

Novel tropane-based compounds were synthesized exhibiting antiproliferative properties against HepG2 and MCF7 carcinoma cell lines.

Orange prismatic crystals of the supramolecular coordination polymer (SCP) ∞ 3 [Cu(CN) 2 (Me Sn)(Pyz)], SCP 1 , were synthesized using a self‐assembly method under ambient conditions. Nanosized was obtained same molar ratio in water by ultrasonic irradiation. characterized single‐crystal X‐ray diffraction, elemental analysis, thermal analysis and Fourier transform infrared spectroscopy. its nanosized particles also examined powder X‐ay diffraction scanning electron microscopy. The...

Potent antitumor active (HeLa, cervical carcinoma cell line) indole-based compounds were synthesized<italic>via</italic>azomethine ylide 1,3-dipolar cycloaddition with 3,5-arylidene-4-piperidones.

Abstract The reactions of 5-azido-3-methyl-1-phenyl-1 H -pyrazole-4-carbaldehyde (azidopyrazole) with several classes organophosphorus reagents: phosphonium ylides, Wittig-Horner reagents, dialkylphosphonates, trialkylphosphites, tris(dialkylamino)phosphanes, triphenylstibane, triphenylarsane, and Lawesson’s reagent are reported. Structural reasoning for the new products was based on compatible analytical spectral data. cytotoxic activity most evaluated against human breast carcinoma cell...

3,5-Bis(arylidene)-N-substituted-4-oxo-piperidine-1-carboxamides 24-51 were synthesized as curcumin mimics in a facile pathway through reaction of 3,5-bis(arylidene)-4-piperidones with the appropriate isocyanate presence triethylamine. The 3E,5E'-stereochemical configuration was conclusively supported by single crystal X-ray studies compounds 25 and 34. Most piperidinecarboxamides showed high anti-proliferative properties potency higher than that 5-fluorouracil (clinically approved drug...

In the title mol-ecule, C(27)H(24)N(2)O(2), pyrrolidin-2-one ring is almost planar (r.m.s. deviation = 0.003 Å), pyrrolidine has an envelope conformation (the N atom flap atom) and cyclo-penta-none twisted about C(q)-C(m) bond (q quaternary m methylene). The ketone O atoms are directed to opposite sides of mol-ecule. Supra-molecular chains along a axis formed in crystal packing mediated by N-H⋯N C-H⋯O inter-actions. These connected into layers ab plane via C-H⋯π

Abstract Two 5 H -indeno[1,2- b ]pyridines, 7a and 7b , were synthesized characterized by X-ray crystallography. In the molecular packing, molecules of are linked into chains C–H···N hydrogen bond which, in turn, connected H···π, N···π, Cl···π π···π interactions. crystal structure C–H···Cl interactions as well a set N···π The structures studied theory using AM1, PM3 DFT. basic difference between theoretical experimental was found relative orientation dichlorophenyl ring attached to...

A set of dispiro[indoline-3,2'-pyrrolidine-3',3''-pyrrolidines] 8a-l was regioselectively synthesized utilizing multi-component azomethine cycloaddition reaction 3-(arylmethylidene)pyrrolidine-2,5-diones 5a-e, isatins 6a-c and sarcosine 7. Single crystal X-ray studies 8c add conclusive support for the structure. Compounds 8e 8g reveal cholinesterase inhibitory properties with promising efficacy against both AChE BChE were found to be more selective towards than as indicted by selectivity...

A new thiosemicarbazone ligand was synthesized and characterized using spectroscopic techniques (UV-Vis IR) synchrotron x-ray powder diffraction. With M2+ = Mn2+, Zn2+ Cd2+, coordination compounds of the type (M[L]2) were isolated. In presence sodium dithiocarbamate salts (NadiEtdtc.3H2O diethyldithiocarbamate trihydrate Napipdtc piperidinedithiocarbamate), Cd2+ able to form ternary octahedral complexes where each metal binds a deprotonated (thiosemicarbazone) ligand, monobasic water...

Pyrrolo-pyrazoles were obtained from the reaction between phosphacumulenes and aminoantipyrine, while with phosphaallene (hexaphenylcarbodiphosphorane ylide) afforded azaphosphole pyrazolo-phosphanylidene. The aminocoumarin carbaldehyde gave chromeno-phosphanylidene chromeno-pyridinone, when it was allowed to react phosphacumulenes. of chloroquinoline phosphacumulenes, phosphanylidenecyclobutane, resulted in formation oxaphosphetane, phosphanylidene ethenyl- oxaphosphetyl-quinoline....

Abstract A series of unexpected bis-coumarins have been synthesized by multicomponent reactions 4-hydroxycoumarin, aldehydes, and cyclic secondary amines in ethanol at room temperature. The chemical structures new compounds were identified 1 H, 13 C NMR, mass spectrometry. Furthermore, the molecular structure solid-state adduct 3,3′-[(4-methoxyphenyl)-methylene]bis(4-hydroxy-2 H -chromen-2-one) with morpholine (1:1) has confirmed single-crystal X-ray diffraction. cytotoxicity coumarin...

Two 3-(arylmethylidene)pyrrolidine-2,5-diones,<bold>12a</bold>and<bold>12b</bold>, were synthesized and characterized by powder X-ray diffraction utilizing a high-resolution synchrotron technique as well DFT calculations.

3‐(2,4‐Dichlorophenyl)‐7‐[(2,4‐dichlorophenyl)methylidene]‐11‐methyl‐4‐phenyl‐4,5,11‐triazatricyclo[6.2.1.0*2,6*]undec‐5‐ene ( 3 ) was synthesized in a stereoselective manner. Single crystal X‐ray study of revealed that the structure belongs to triclinic system with space group . The is further stabilized by an intermolecular CH … π interaction. Molecular mechanics force field (MM + ), followed either semi‐empirical AM1 or PM3, used calculate optimized geometrical parameters determined...

New host‐guest supramolecular coordination polymer catalyst 3 ∞ [Co(μ 2 CN) 5 (CN)(μ ‐Me Sn) (Me Sn)(H O)(qox)], SCP1 (qox = quinoxaline) has been synthesized and characterized by single crystal X‐ray diffraction, FT‐IR, U V /Visible fluorescence spectra, thermal elemental analyses. The tin atoms act as bridges connecting the Co (CN) 6 building blocks. structure of exhibits an unusual self‐coordinated 3D network with qox guest molecule. Also, nanosized1 \ was prepared under ultrasonic...

Aim: Synthesis of novel bronchodilatory active indole–pyridine conjugates. Results/methodology: Indole–pyridine conjugates (6a–n, 8a–i and 10a–c) were synthesized in a facile pathway through reaction 2-[(1-alkyl-1H-indol-3-yl)methylene]malononitriles 4a,b with the corresponding ketone-containing compounds (5a–f, 7a–c 9a,b) presence sodium alkoxide. Single (6l, 8 g) powder (6k, 8d) x-ray studies supported structures. Results: Histamine precontracted isolated tracheal rings guinea pig...

A set of vasorelaxant active 4-hydroxyquinazoline-4-carboxamides was obtained in a novel synthetic approach <italic>via</italic> secondary amine nucleophilic reaction with 2,3-dioxoindoline-1-carboxamides.

∞ 3 [{Co(hmt) 2 (NCS) (H O) }{Co(NCS) 4 }(2H O)] supramolecular complex ( SC ) had been synthesized through self‐assembly reaction using the sonochemical method at ambient conditions. The structure was fully characterized by single‐crystal X‐ray diffraction and spectroscopic methods. consists of two separate distinct complexes containing crystallography chemically different Co II atoms, four thiocyanate ligands, hmt six coordinated water molecules, one uncoordinated molecule. (SCN) fragments...

Aporosa octandra (Buch.-Ham. ex D.Don) Vickery is a native species of India. Different parts the plant are used for medicinal purpose by tribal peoples south-eastern part However, biological properties A. have not been studied well. The extracts obtained from bark were evaluated to determine their protective effect on cognitive impairment and oxidative stress in mice induced D-galactose using standard protocol. dosages extract AOE-4 (100, 200, 300 mg/kg, p.o.) administered mice, which...