A5040909685- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis of Organic Compounds
- Synthesis and Reactivity of Heterocycles
- Crystallization and Solubility Studies
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- X-ray Diffraction in Crystallography
- Organic Chemistry Cycloaddition Reactions
- Chemical Reaction Mechanisms
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Marine Sponges and Natural Products
- Organic and Inorganic Chemical Reactions
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Pyrroles
- Marine Biology and Environmental Chemistry
- Organic and Molecular Conductors Research
- Asymmetric Synthesis and Catalysis
- Synthesis and pharmacology of benzodiazepine derivatives
National Research Centre
1979-2018
Housing and Building National Research Center
1994
Odense University Hospital
1987
Abstract The facile synthetic approaches to 3‐pyridinecarbonitriles are described. first approach involves the base‐catalyzed transformation of 4‐hydroxy‐1,1‐cyclohexanedicarbonitrile 2a into 4a, b . other route multi‐step one‐pot reaction aryl methyl ketones with appropriate arylidenemalononitriles 6, 11a, Careful study synthesis 2a, from 1a, revealed importance controlling conditions. Thus, 1,7‐dioxo‐4,4‐heptanedicarbonitriles 3a, or 3‐pyridinecarbonitrile 4a were obtained in addition...
The cycloaddition of arylnitrile N-oxides to the exocyclic double bond arylmethylidenes derived from indane-1,3-dione 1a–c, indan-1-one 1d–f and 1-tetralone 1g–i afforded spiroisoxazolines 2a–l with high regioselectivity not corresponding isomers 3a–l.
La reaction passe par l'intermediaire d'enolates d'heptanediones-2,6 en milieu anhydre sur lesquels on additionne des isothiocyanates d'aryle
Abstract Chlorosulfonyl isocyanate reacts with hydroxynitrostyrenes 1 to give the corresponding N ‐unsubstituted carbamates 3 . The latter undergo transesterification p ‐toluenesulfonyl chloride sulfonates 4 analogous phosphates 5 are obtained by treating diethyl chlorophosphate Compounds 3, , and present a novel series of aryl‐β‐nitroalkenes pesticidal importance. react o ‐phenylenediamine afford benzimidazolone along 2‐arylbenzimidazoles 7 molluscicidal antimicrobial activities products discussed.
2-Hydroxychalcones 1a, b react readily with alkyl and aryl isocyanates in the presence of potassium hydroxide to give directly corresponding 3-alkyl- 3-aryl-3,4-dihydro-4-phenacyl-2H-1,3-benzoxazin-2-ones 3. The 2-thione analogues 5a, are similarly obtained by reacting methyl isothiocyanate. Thiones 5 oxidized yellow mercuric oxide oxo compounds direct formation benzoxazinones from chalcones apparently proceeds through intermediate open chain carbamates.The latter cleaved p-toluenesulfonyl...
Two azaphenanthrenes were synthesised by a facile synthetic pathway and characterised X-ray crystallography. Molecular packing of 4-(2,4-dichlorophenyl)-2-methoxy-5,6-dihydrobenzo[ h]quinoline-3-carbonitrile exhibits C–H…N C–H…Cl hydrogen bonds in addition to intermolecular C–H…π, Cl…π π…π (π-ring) stacking interactions. However, molecules the 2-ethoxy derivative are linked into chains one bond type crystal structure reveals an C–H…π interaction. Computational studies AM1, PM3, density...
Reaction of the2-arylmethylidene-2,3-dihydro-1H -inden-1-ones 1a–fwith malononitrile in alcoholic KOH affords2-alkoxy-4-aryl-5H -indeno[1,2-b ]pyridine-3-carbonitriles 2a–l and(2-arylmethyl-2,3-dihydro-1H -inden-1-ylidene)dicyanomethanes 6a–f.
Abstract An effective synthesis of 3‐benzoyl‐2(1 H )‐pyridinethiones 5a – n from stable enol salts 4 pentene‐1,5‐diones and isothiocyanates is described. attempt to prepare a 3‐acetyl‐2(1 )‐pyridinethione the cyano compound 7 CH 3 MgX yielded ketimine 8 .
2,4-Bismethylthiopyridinium iodides prepared from 2(1 H)-pyridinethiones react regioselectively with active methylene compounds, preferentially at the 4-position, yielding 4-alkylidene-1,4-dihydropyridines. The corresponding 4-benzylthio-2-methylthiopyridinium iodide gave a mixture of 2-alkylidene-1,2-dihydro- and By treatment phosphoric acid, resulting new 3-acetyl-2-alkyliden-1,2-dihydro- 4-alkylidene-1,4-dihydropyridines yielded 1,6- 2,7-naphthyridines, respectively.
Abstract Aldol condensation of 3‐formyl‐2(1 H )‐pyridinethiones and the corresponding pyridones with ketones such as acetophenones in aqueous base yields 3‐hydroxy‐1‐propanones high yields. Reaction propiophenone showed this reaction to be highly diastereoselective only erythro ‐isomer is formed at room temperature. This assignment was based on an X‐ray crystallographic investigation compound given title. condensations a number related 3‐acetyl‐2(1 benzaldehyde yielded trans ‐vinyl ketones.
Anions 3 of 1,5-pentenediones can be alkylated to give 2-alkyl-1, 5-pentenediones 4, whose anions 5 react with isothiocyanates yield the oxoenoles 7. These cyclize new 5-substituted 2(1H)-pyridinethiones 6 in fair yields. unsymmetrical yields mixtures 9 and 10.
Abstract 5‐Chloro‐3‐formylsalicylic acid ( 1 ) is readily obtained by reaction of 5‐chlorosalicylic with chloroform in alkali. condenses nitromethane to give 5‐chloro‐3‐(2‐nitroethenyl)‐salicylic 2 which anilines through its chloride at low temperature the title anilides 4 . However, when condensation conducted higher temperature, corresponding azomethines 5 are produced. The latter also treating temperature. molluscicidal and fungicidal activities products discussed.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”