A5088784375- Environmental Toxicology and Ecotoxicology
- Toxic Organic Pollutants Impact
- Insect and Pesticide Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Insect Pest Control Strategies
- thermodynamics and calorimetric analyses
- Physiological and biochemical adaptations
- Water Quality and Pollution Assessment
- Pesticide Residue Analysis and Safety
- Statistical and Computational Modeling
- Species Distribution and Climate Change
- Insect and Arachnid Ecology and Behavior
- Animal testing and alternatives
- Insect Resistance and Genetics
Wageningen University & Research
2021-2023
University of York
2022
RWTH Aachen University
2020-2021
University of Saskatchewan
2020-2021
In the face of global climate change, where temperature fluctuations and frequency extreme weather events are increasing, it is needed to evaluate impact on ecological risk assessment chemicals. Current state-of-the-art mechanistic effect models, such as toxicokinetic–toxicodynamic (TK–TD) often do not explicitly consider a modulating factor. This study implemented in widely used modeling framework, General Unified Threshold model for Survival (GUTS). We tested using data from toxicokinetic...
A comprehensive understanding of chemical toxicity and temperature interaction is essential to improve ecological risk assessment under climate change. However, there only limited knowledge about the effect on chemicals. To fill this gap our mechanistic influence temperature, current study explored toxicokinetics chronic effects two insecticides, imidacloprid (IMI) flupyradifurone (FPF), Gammarus pulex at different temperatures (7-24 °C). In tests, organisms were exposed IMI or FPF for 2...
Flupyradifurone (FPF) is a new type of butenolide insecticide. It was launched on the market in 2015 and considered an alternative to widely used neonicotinoids, like imidacloprid (IMI), some which are banned from outdoor use European Union. FPF claimed be safe for bees, but its safety aquatic organisms unknown. Its high water solubility, persistence environment, potential large-scale make it urgent evaluate possible impacts systems. The current study assessed acute chronic toxicity...
Standardized laboratory tests with a limited number of model species are key component chemical risk assessments. These surrogate cannot represent the entire diversity native species, but there practical and ethical objections against testing chemicals in large variety species. In previous research, we have developed multispecies toxicokinetic to extrapolate bioconcentration across by combining single-species physiologically based (PBTK) models. This "top-down" approach was limited, however,...
Delayed toxicity is a phenomenon observed for aquatic invertebrates exposed to nicotinic acetylcholine receptor (nAChR) agonists, such as neonicotinoids. Furthermore, recent studies have described an incomplete elimination of neonicotinoids by amphipods. However, mechanistic link between binding and toxicokinetic modeling has not been demonstrated yet. The the neonicotinoid thiacloprid in freshwater amphipod Gammarus pulex was studied several exposure experiments, complemented with vitro...
The white sturgeon (Acipenser transmontanus) is an endangered ancient fish species that known to be particularly sensitive certain environmental contaminants, partly because of the uptake and subsequent toxicity lipophilic pollutants prone bioconcentration as a result their high lipid content. To better understand organic contaminants in this species, toxicokinetic (TK) models were developed for embryo-larval subadult life stages. model was designed one-compartment validated using whole-body...
Temperature is a crucial environmental factor affecting the distribution and performance of ectothermic organisms. This study introduces new temperature damage model to interpret their thermal stress. Inspired by ecotoxicological in General Unified Threshold for Survival (GUTS) framework, assumes that depends on balance between temperature-dependent accumulation constant repair. Mortality due stress driven level exceeding threshold. Model calibration showed good agreement with measured...
<ns4:p>By 2050, the global population is predicted to reach nine billion, with almost three quarters living in cities. The road 2050 will be marked by changes land use, climate, and management of water food across world. These (GCs) likely affect emissions, transport, fate chemicals, thus exposure natural environment chemicals.</ns4:p><ns4:p> ECORISK2050 a Marie Skłodowska-Curie Innovative Training Network that brings together an interdisciplinary consortium academic, industry governmental...
By 2050, the global population is predicted to reach nine billion, with almost three quarters living in cities. The road 2050 will be marked by changes land use, climate, and management of water food across world. These (GCs) likely affect emissions, transport, fate chemicals, thus exposure natural environment chemicals. ECORISK2050 a Marie Skłodowska-Curie Innovative Training Network that brings together an interdisciplinary consortium academic, industry governmental partners deliver new...