A5022648687- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
Dartmouth College
2020-2023
Abstract CD8 T cell differentiation is orchestrated by dynamic metabolic changes that direct activation, proliferation, cytotoxic function, and epigenetic changes. We report the BTB-ZF family transcriptional repressor Zbtb20 negatively regulates metabolism memory in mice. Effector cells with conditional deficiency displayed enhanced mitochondrial glycolytic metabolism, had spare respiratory capacity. Furthermore, Zbtb20-deficient increased flexibility use of fuel sources. Phenotypic skewing...
Members of the BTB-ZF transcription factor family regulate immune system. Our laboratory identified that member Zbtb20 contributes to differentiation, recall responses, and metabolism CD8 T cells. Here, we report a characterization transcriptional epigenetic signatures controlled by at single-cell resolution during effector memory phases cell response. Without Zbtb20, programs associated with formation were up-regulated throughout A signature open chromatin was genes controlling activation,...
Persistent infection with gammaherpesviruses (γHV) can cause lymphomagenesis in immunocompromised patients. Murine γHV-68 (MHV-68) is an important tool for understanding immune factors contributing to γHV control; however, modeling control of γHV-associated has been challenging. Current model systems require very long incubation times or severe suppression, and tumor penetrance low. In this report, we describe the generation a B cell lymphoma on C57BL/6 background, which driven by Myc...
Abstract Members of the BTB-ZF transcription factor family regulate immune system. Our lab identified that member Zbtb20 contributes to differentiation, recall responses and metabolism CD8 T cells. Here, we report a characterization transcriptional epigenetic signatures controlled by at single-cell resolution during effector memory phases cell response. Without Zbtb20, programs associated with formation were upregulated throughout A signature open chromatin was genes controlling activation,...