A5005203463- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Inflammatory mediators and NSAID effects
- Synthesis and biological activity
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Reproductive System and Pregnancy
- Chemokine receptors and signaling
- CAR-T cell therapy research
- COVID-19 Impact on Reproduction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- melanin and skin pigmentation
- Bladder and Urothelial Cancer Treatments
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- International Student and Expatriate Challenges
- Cellular Mechanics and Interactions
- Nanoplatforms for cancer theranostics
- HIV Research and Treatment
- Single-cell and spatial transcriptomics
- Healthcare Systems and Technology
Dartmouth College
2015-2022
University of Miami
2012-2017
Falmouth Hospital
2017
University of Florida
2007
UNSW Sydney
1997
Hyogo Medical University
1996
Tissue-resident memory T (TRM) cells have been widely characterized in infectious disease settings; however, their role mediating immunity to cancer remains unknown. We report that skin-resident cell responses melanoma are generated naturally as a result of autoimmune vitiligo. Melanoma antigen-specific TRM resided predominantly melanocyte-depleted hair follicles and were maintained without recirculation or replenishment from the lymphoid compartment. These expressed CD103, CD69, CLA...
Abstract Purpose: Myeloid-derived suppressor cells (MDSC) and regulatory T (Treg) play a key role in the progression of head neck squamous cell carcinoma (HNSCC). On basis our preclinical data demonstrating that phosphodiesterase-5 (PDE5) inhibition can modulate these populations, we evaluated whether PDE5 inhibitor tadalafil revert tumor-induced immunosuppression promote tumor immunity patients with HNSCC. Experimental Design: First, functionally phenotypically characterized MDSCs HNSCCs...
BACKGROUND/AIMS: The role of host factors has been neglected in studies the pathogenesis Helicobacter associated disease. aim this study was to assess response different mouse strains infection with a single strain felis. METHOD: Six inbred mice were infected identical H felis culture and killed at one month, two months, six months after histopathological changes. In addition, adapted pylori examined infection. RESULTS: SJL, C3H/He, DBA/2, C57BL/6 mice, severe moderate chronic active...
In addition to promoting tumor progression and metastasis by enhancing angiogenesis invasion, myeloid-derived suppressor cells (MDSC) tumor-associated macrophage (TAM) also inhibit antitumor T-cell functions limit the efficacy of immunotherapeutic interventions. Despite importance these leukocyte populations, a simple method for their specific depletion has not been developed. this study, we generated an RNA aptamer that blocks murine or human IL-4 receptor-α (IL4Rα CD124) is critical MDSC...
N-MYC is a transcription factor that plays an important role in cellular survival neuroblastoma, and amplification of the oncogene primary adverse prognostic indicator for neuroblastoma. Focal adhesion kinase (FAK) has been shown to be overexpressed many types human cancers. In this study, we investigated regulation FAK expression We first found correlation between Real time quantitative PCR demonstrated increase mRNA abundance N-MYC-amplified IMR-32 compared with nonamplified SK-N-AS...
Atrophic gastritis caused by Helicobacter pylori is the precursor lesion in development of intestinal-type gastric adenocarcinoma. In animal models, atrophic induced felis has been shown to be host dependent, developing some mouse strains and not others. The lipopolysaccharide (LPS) H. suggested play a role induction gastritis. goal this study was compare inflammation long-term infection C3H/He C3H/HeJ mice with felis. are unresponsive LPS. Six months after infection, severe had developed...
Tissue-resident memory (T RM ) T cells are emerging as critical components of the immune response to cancer; yet, requirements for their ongoing function and maintenance remain unclear. APCs promote cell differentiation re-activation but have not been implicated in sustaining responses. Here, we identified a novel role dendritic supporting melanoma. We showed that CD8 close proximity skin. Depletion CD11c + results rapid disaggregation eventual loss melanoma-specific cells. In addition,...
Abstract Exploring the mechanisms controlling lymphocyte trafficking is essential for understanding function of immune system and pathophysiology immunodeficiencies. The mammalian Ste20–like kinase 1 (Mst1) has been identified as a critical signaling mediator T cell migration, loss Mst1 results in immunodeficiency disease. Although known to support migration through induction polarization lamellipodial formation, downstream effectors are incompletely defined. Mice deficient actin-bundling...
Forkhead box protein P3 (FOXP3) expression in tumor infiltrating CD4+T cells is generally associated with an intrinsic capacity to suppress immunity. Based on this notion, different studies have evaluated the prognostic value of maker cancer but contradictory results been found. Indeed, even within same population, presence CD4+FOXP3+T has associated,with either a poor or good prognosis, no correlation beenfound. Here, we demonstrate,in patients oral squamous cell carcinoma (OSCC), that what...
Abstract Myeloid cells play a key role in tumor progression and metastasis by providing nourishment immune protection, as well facilitating cancer invasion seeding to distal sites. Although advances have been made understanding the biology of these tumor-educated myeloid (TEMCs), their intrinsic plasticity challenges our further biology. Indeed, vitro experiments only mimic vivo setting, current gene-knockout technologies do not allow simultaneous, temporally controlled, cell-specific...
Immunomodulatory cellular subsets, including myeloid-derived suppressor cells (MDSCs) and T regulatory (Tregs), contribute to the immunosuppressive tumour microenvironment are targets of immunotherapy, but their role in retroviral-associated immunosuppression is less well understood. Due known crosstalk between Tregs MDSCs microenvironment, also hypothesized involvement during human immunodeficiency virus/simian virus infection, studying interplay these immune LP-BM5 retrovirus-induced...
The ongoing COVID-19 crisis has redirected attention to the importance of robust risk management practices and well-established cultures within financial institutions. Various studies have highlighted positive implications strong on performance market rewards during a single-wave crisis. Are these findings, however, consistent also across multiple-wave prolonged crisis? To answer this, authors analyse period ranging from 2008 2011 using dataset comprising 13 systemically important European...
Abstract Introduction: Depending on their polarization, myeloid cells can either promote or restrain tumor progression. By secreting myelopoietic factors tumours polarization toward a phenotype that provides immune protection and stimulate neoplastic growth, invasiveness, metastasis. Chemokines cognate receptors are thought to play key role in cell trafficking, however, study vivo is hindered by signal redundancy integration. Methods: taking advantage of newly developed nanoplatform allows...
Abstract Dendritic cells (DC) are fundamental in the initiation of adaptive immune response. Following antigen uptake, tissue-resident DCs undergo maturation preparation for their migration to lymph nodes where they present processed T cells. Down-regulation tissue-homing receptors and upregulation lymphoid-homing receptors, including CCR7 is required dendritic cell entry into afferent lymphatic vessels. binding its ligands, CCL19 CCL21, provides appropriate directional cues traffic nodes....
Abstract Immunomodulatory cellular subsets, including myeloid derived suppressor cells (MDSCs) and T regulatory (Tregs), contribute to the immunosuppressive tumor microenvironment have been targets of immunotherapy, but their role in retroviral-associated immunosuppression is less understood. Due known crosstalk between Tregs MDSCs microenvironment, it interest look at interplay these immune during LP-BM5-induced murine AIDS. Following vivo natural Treg (nTreg) depletion, subsequent LP-BM5...
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<p>Supplementary methods. Description of the patients for retrospective and prospective study, list inclusion exclusion criteria, detailed protocol immunofluorescence analysis.</p>
<p>Supplementary figure 1. Gating strategy for MDSCs enumeration in the blood</p>