A5018897617- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Reproductive System and Pregnancy
- HIV Research and Treatment
- Reproductive tract infections research
- Reproductive Health and Contraception
- HIV-related health complications and treatments
- Immune Response and Inflammation
- Healthcare cost, quality, practices
Emory University
2017-2020
Grady Health System
2020
Background Understanding the immune profile of CD4 T cells, primary targets for HIV, in female genital tract (FGT) is critical evaluating and developing effective biomedical HIV prevention strategies women. However, longitudinal investigation susceptibility markers expressed by FGT cells has been hindered low cellular yield risk sampling-associated trauma. We investigated three minimally invasive sampling methods to characterize compare cell phenotype with goal establishing feasible...
Background While prior epidemiologic studies have suggested that injectable progestin-based contraceptive depot medroxyprogesterone acetate (DMPA) use may increase a woman's risk of acquiring HIV, recent data DMPA users be at similar for HIV acquisition as the copper intrauterine device and levonorgestrel implant. Use etonogestrel Implant (Eng-Implant) is increasing but there are currently no evaluating its effect on risk. Objective Evaluate potential Eng-Implant by analyzing target cells...
Despite plasma virologic suppression with antiretroviral therapy (ART), HIV persists in gut tissue. The objectives of this study were to compare and rectal tissue RNA dynamics assess relationships dolutegravir (DTG) concentrations.
Background Adolescent and young adult women (AYAW), particularly racial ethnic minorities, in the Southern United States are disproportionately affected by HIV. Pre-exposure prophylaxis (PrEP) is an effective, scalable, individual-controlled HIV prevention strategy that grossly underutilized among of all ages requires innovative delivery approaches to optimize its benefit. Anchoring PrEP family planning (FP) services AYAW already trust, access routinely, deem useful for their sexual health...
Abstract Lifetime trauma, stress exposure, and current perceived are believed to lower immune responsiveness infections but their effect on cell targets of HIV infection pathogenesis not known. We examined lifetime trauma for associations with target cells in genital mucosa PBMC from 50 STI negative women reproductive age. Validated scores the number traumatic exposures victimization history (LTVH) instrument, 51-item Chronic Stress Scale (CSS) 10-item scale (PSS) were compiled. Paired...
<sec> <title>BACKGROUND</title> Adolescent and young adult women (AYAW), particularly racial ethnic minorities, in the Southern United States are disproportionately affected by HIV. Pre-exposure prophylaxis (PrEP) is an effective, scalable, individual-controlled HIV prevention strategy that grossly underutilized among of all ages requires innovative delivery approaches to optimize its benefit. Anchoring PrEP family planning (FP) services AYAW already trust, access routinely, deem useful for...