A one-pot procedure for the synthesis of 1,2,3-triazole derivatives by a three-component coupling alkyl (benzyl) halides or aryl boronic acids, sodium azide and terminal alkynes over copper(II) sulfate supported on alumina (Cu/Al2O3) under ball-milling in absence any solvent additive has been developed. The product was isolated simple washing crude reaction residue with ethanol followed evaporation solvent. No chromatographic purification is required. catalyst recycled subsequent reactions....

Highly selective reduction of nitroarenes has been achieved using iron metal nanoparticles in water at room temperature. A wide spectrum reducible functionalities remained inert under the reaction conditions. During a change shape Fe was observed.

A convenient, efficient, and general procedure for the synthesis of diaryl chalcogenides including sulfides, selenides tellurides has been developed by reaction diazonium tetrafluoroborates dichalcogenides on surface alumina under ball-milling without any solvent or metal. wide range functionalized are obtained in high purity this procedure.

A general and efficient procedure has been developed for the synthesis of organochalcogenides (selenides tellurides) by a simple reaction organoboronic acids dichalcogenides catalysed CuFe2O4 nanoparticles in PEG-400 without any ligand. This protocol offers scope access to wide spectrum chalcogenides including diaryl, aryl–heteroaryl, aryl–styrenyl, aryl–alkenyl, aryl–allyl, aryl–alkyl aryl–alkynyl versions. The catalyst is magnetically separable recyclable eight times loss appreciable...

Among the many types of transition-metal-catalysed C–C bond forming reactions, olefin metathesis is without a doubt one most thriving fields in modern organic synthetic chemistry.

Abstract Traditionally, a metal‐catalyzed cross‐coupling reaction is governed by displacement of leaving groups such as halogens, tosylates, etc. different nucleophiles leading to the formation carbon‐carbon and carbon‐heteroatom bonds. Besides traditional in coupling reactions decyanative has also received current attention. The objective this work develop through metal‐assisted nucleophilic displacement, which less explored so far. Thus, aryl selenocyanate with aryl‐/alkylacetylenes,...

Abstract A selective N‐arylation of cyclic amides and amines in DMF water, respectively, catalysed by Cu II /Al 2 O 3 has been achieved. This protocol employed for the synthesis a library arenes bearing amide an amine moiety at two ends, including few scaffolds therapeutic importance. The mechanism established based on detailed electron paramagnetic resonance (EPR) spectroscopy, X‐ray photoelectron spectroscopy (XPS), UV diffuse reflectance (DRS) inductively coupled plasma‐mass spectrometry...

An efficient cross coupling of alkynes with alkynyl and alkenyl halides catalysed by a Ni–Cu system without any ligand leading to the synthesis series functionalised 1,3-di-ynes en-ynes has been achieved.

Overproduction of nitric oxide (NO) by inducible nitric-oxide synthase (iNOS) has been etiologically linked to several inflammatory, immunological, and neurodegenerative diseases. As dimerization NOS is required for its activity, inhibitors, including pyrimidine imidazoles, are being evaluated therapeutic inhibition iNOS. However, the precise mechanism their action still unclear. Here, we examined iNOS a imidazole core compound derivative (PID), having low cellular toxicity high affinity...

Abstract Mechanochemical synthesis of nine contemporary ruthenium catalysts used for olefin metathesis is described, being the first reported example formation Ru carbene organometallic complexes in solid state. Three key transformations commonly second and third generations solution—phosphine ligand (PCy 3 ) exchange with situ formed N‐heterocyclic (NHC) ligand, PCy to pyridine replacement, benzylidene ligands interchange—were proved work under mechanochemical conditions, affording targets...

Abstract A heterogeneous Co II /Al 2 O 3 catalyst efficiently catalyses the N ‐arylation of N‐heterocycles and open‐chain secondary amines by activated chloroarenes chloroheteroarenes under ligand‐free conditions in water to give a series functionalized tertiary amines. The was prepared immobilizing CoBr onto surface Al , characterized X‐ray diffraction, photoelectron spectroscopy, scanning electron microscopy, energy‐dispersive analysis. This could be recycled up six times without any...

Background: In this Chapter an overview on visible light photocatalyzed carbonheteroatom bond formations (C-N, C-O, C-P, C-S/Se/Te etc.) and the synthesis of related compounds by environment friendly approach has been reported. We have discussed C-N formation including amination, imination, azidation, amidation. Construction C-O C-P also studied photoredox catalysis under irradiation implicating a novel, powerful green strategy. Visible photocatalysis is useful in bonds avoiding harsh...

Silver(I) catalyzed phenylselenylation of terminal alkynes and organoboronic acids has been demonstrated using N-(phenylseleno)phthalimide as an electrophilic SePh donor. A wide variety are selenylated efficiently to produce the corresponding alkynyl diaryl selenides, respectively, in good yields. acts a Lewis acid this process.

A transition metal-and solvent-free procedure for the reaction of aryl diazonium tetrafluoroborates and thiols or selenols over alumina surface under ball-milling at ambient temperature, has been developed synthesis unsymmetrical diaryl aryl-alkyl sulfides selenides.A wide range functionalized selenides were obtained in high yields purity within a short time (5-8 min.)by this protocol.

Background: The microwave reactor has been an important tool in organic synthesis. During last two decades radiation successfully used a variety of reactions including carbon- carbon and carbon-heteroatom bond formation. application energy for carbonchalcogen formation leading to the synthesis chalcogenides have reported by various groups. Considering importance organo-chalocogenides pharmaceutical industries this review is initiated assemble these results one article. Keywords: Bond...

Abstract Carbon–carbon and carbon–heteroatom bond-formation reactions catalyzed by benign inexpensive metals are of much interest in organic synthesis, as these provide green cost-effective routes. This account summarizes our recent contributions to the construction carbon–carbon bonds using benign-metal catalysts. A number bond formations, including C–N, C–O, C–S, C–Se, C–Te, C–P discussed. Mechanistic insights into several also reported 1 Introduction 2 C–C Bond Formation 3 C–N C–O 4...

Abstract Review: 66 refs.

Mechanochemistry, a solvent-free approach that harnesses mechanical energy, is emerging as transformative technique in modern chemistry. It has emerged from niche to versatile tool with broad applications. By inducing physical and chemical transformations, it enables the synthesis of complex molecules nanostructured materials. Recent advancements have extended its applications beyond simple transformations encompass catalytic processes, unlocking new possibilities for selective product...

Abstract An efficient protocol for the N‐arylation of different cyclic amides and amines under convenient conditions is described.