A one-pot procedure for the synthesis of 1,2,3-triazole derivatives by a three-component coupling alkyl (benzyl) halides or aryl boronic acids, sodium azide and terminal alkynes over copper(II) sulfate supported on alumina (Cu/Al2O3) under ball-milling in absence any solvent additive has been developed. The product was isolated simple washing crude reaction residue with ethanol followed evaporation solvent. No chromatographic purification is required. catalyst recycled subsequent reactions....

Decarboxylative Chan–Evans–Lam-type couplings are presented as a new strategy for the regiospecific construction of diaryl and alkyl aryl ethers starting from easily available aromatic carboxylic acids. They allow converting various carboxylate salts into corresponding by reaction with orthosilicates or borates, under aerobic conditions in presence silver carbonate decarboxylation catalyst copper acetate cross-coupling catalyst.

One in, one out: In the presence of a copper/silver bimetallic catalyst system, aromatic carboxylate salts undergo ortho CH alkoxylation with concomitant loss directing group in protodecarboxylation step (see scheme, FG=functional group). This process provides convenient synthetic access to important class ethers from widely available carboxylic acids.

A convenient, green and efficient procedure for the synthesis of aryl vinyl dithiocarbamates has been developed by a simple one-pot three component condensation an amine, carbon disulfide, iodide or styrenyl bromide catalyzed copper nanoparticles in water. Significantly, (E)- (Z)-styrenyl bromides provide corresponding high diastereoselectivities. The catalyst is recycled.

What a couple! Arenes functionalized with donating groups undergo oxidative dehydrogenative coupling alcohols in the presence of copper/silver catalyst system. This intermolecular CH alkoxylation provides convenient synthetic route to important class aryl ethers. The system also allows benzylic formation benzyl alkyl

A convenient, efficient and green procedure for the synthesis of S-aryl dithiocarbamates has been developed by a simple one-pot condensation aryl diazonium fluoroborate, carbon disulfide amine in absence any transition metal catalyst water at room temperature. The reactions variety substituted fluoroborates, cyclic open chain amines, have addressed. products are purified crystallization from ethanol process does not involve hazardous solvent.

Abstract Alumina‐supported copper sulfate efficiently catalyzes the S ‐arylation of aromatic, heteroaromatic and aliphatic thiols with aryl as well heteroaryl halides under aerobic, ligand‐free conditions. This protocol provides an easy access to a variety thioethers unsymmetrical bis‐thioethers by base‐controlled differential coupling iodo‐ bromo‐substituents in aromatic halide. The catalyst is inexpensive, non‐air sensitive, environmentally friendly recyclable.

An easily accessible catalyst, alumina-supported copper(II), efficiently catalyzes the ring opening of aziridines and epoxides followed by cyclization corresponding intermediate to produce a variety functionalized 1,4-benzoxazines 1,4-benzodioxanes, respectively, in one pot without any ligand high yields. The cleavages are highly regioselective. catalyst is inexpensive, non-air-sensitive, environmentally friendly, recyclable. function reaction pathway postulated. This protocol successfully...

Alumina-supported copper sulfate efficiently catalyzes electrophilic substitution in organoborane, organosilanes, and organostannanes by phenylselenium bromide providing a novel efficient route to the synthesis of unsymmetrical diaryl alkyl aryl selenides. A series aryl, alkyl, heteroaryl phenyl selenides were obtained high yields. The catalyst is inexpensive, eco- user-friendly, recyclable. mechanism involving Cu-assisted nucleophilic displacement Br PhSeBr mild nucleophiles described.

A new chiral tethered 8-quinolinol-based ligand class is developed. The binuclear titanium complex of the operates through a novel mechanism allowing for regio- and stereoselective epoxidation primary tertiary homoallylic alcohols (up to 98% ee), as well first examples 2-allylic phenols 92% ee). catalyst system also promotes asymmetric oxidation γ-hydroxypropyl sulfides giving an important sulfoxides that have been inaccessible date 95%

Eine rein, eine raus: In der Gegenwart eines Kupfer/Silber-Katalysatorsystems erfahren aromatische Carboxylatsalze ortho-C-H-Alkoxylierung mit gekoppeltem Verlust carboxylatdirigierenden Gruppe in einem protodecarboxylierenden Schritt (siehe Schema; FG=funktionelle Gruppe). Dieser Prozess eröffnet einen vorteilhaften Zugang zur wichtigen Substanzklasse aromatischen Ether ausgehend von breit verfügbaren Carbonsäuren. As a service to our authors and readers, this journal provides supporting...

Arylacetic acid equivalents, bearing a pyridine group, undergo copper-catalyzed C(sp 3 )–H/C(sp )–H cross-coupling with methylarenes to give α,β-diarylpropionic acids via the formation of α-carbonyl radicals.

Abstract A selective N‐arylation of cyclic amides and amines in DMF water, respectively, catalysed by Cu II /Al 2 O 3 has been achieved. This protocol employed for the synthesis a library arenes bearing amide an amine moiety at two ends, including few scaffolds therapeutic importance. The mechanism established based on detailed electron paramagnetic resonance (EPR) spectroscopy, X‐ray photoelectron spectroscopy (XPS), UV diffuse reflectance (DRS) inductively coupled plasma‐mass spectrometry...

Abstract Pd(0) nanoparticles have been demonstrated to be very efficient catalysts for C–C bond-forming reactions. These include coupling of vicinal -diiodoalkenes and acrylic esters nitriles leading the stereoselective synthesis 2-alkene-4-yn-esters nitriles, allylation active methylene compounds by allyl acetate, Hiyama cross-coupling aryliodides with arylsilanes. Cu(0) catalyze aryl-sulfur bond formation, accomplishing functionalized aryl sulfides aryl- vinyl dithiocarbamates. Cu also...

A copper-based system allows for the methylene insertion between an amine and a milder nucleophile, including terminal alkyne counterpart, via C-N bond cleavage of N,N-dimethylacetamide. The method gives expedient access to propargylic amines in good excellent yields. wide-ranging substrate scope late-stage functionalization complex molecules make protocol practically valuable.

Water promotes hydrothiolation of unactivated alkynes efficiently without any catalyst or additive. The reaction at room temperature furnishes vinyl sulfides with high regioselectivity via anti-Markovnikov addition. terminal provide dithiolanes 80 °C by bis-addition. reactions are very clean and yielding.

Direct asymmetric synthesis of N-chiral amine oxides was accomplished (up to 91:9 e.r.) by means a bimetallic titanium catalyst. A hydroxy group situated at the γ-position N stereocenter enables desired N-oxidation through dynamic kinetic resolution trivalent substrates. The method further extended racemic γ-amino alcohols with preexisting stereocenter, giving an important class enantioenriched 99.9:0.1 building blocks that are otherwise difficult synthesize.

Benzoxazoles and benzothiazoles govern the Pd^II-catalyzed regiospecific methoxylation of proximal-selective α-C(sp³)–H bond to access α-methoxyacetic acids <italic>O</italic>-methylated Breslow intermediates.

The oxidation of thiols to disulfides was achieved in high yields with 6:1 mol ratio thiol NaBrO3, while the sulfides and benzylic/secondary alcohols corresponding sulfoxides aldehydes/ketones successfully undertaken 3:1 substrate NaBrO3. These ratios correspond minimum theoretical requirement reactions were conducted at 0−30 °C, depending upon substrate, initiated catalytic amounts H+ Br− (initial Br−/BrO3− = 1:3.5 for 1:8 sulfide alcohol oxidation). Further, regeneration reuse spent...

A novel approach to α-chalcogenation of aliphatic carboxylic acids has been developed by means transforming them as the corresponding benzazoles. The catalyst system, consisting CuI, DMSO, and a base, operates through unique mechanism access range practically significant thio- selenoethers that are otherwise challenging achieve. applicative potentials have exemplified utilizing resultant chalcogenated compounds precursor for synthesis biologically pertinent molecules synthetic intermediates.