About
Contact & Profiles
A5101400064
Research Areas
- Computational Drug Discovery Methods
- Bipolar Disorder and Treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Heat shock proteins research
- Adenosine and Purinergic Signaling
- thermodynamics and calorimetric analyses
- Tryptophan and brain disorders
- Synthesis and Biological Evaluation
- Biochemical Acid Research Studies
Seoul National University
2020-2021
Daewoong Pharmaceutical (South Korea)
2020
10.1016/j.bmcl.2020.127165
article
EN
Bioorganic & Medicinal Chemistry Letters
2020-04-02
10.1016/j.bmcl.2021.127963
article
EN
Bioorganic & Medicinal Chemistry Letters
2021-03-18
New compounds with 1H-pyrazolo [3,4-d]pyrimidin-6-amine core scaffolds were synthesized and characterized in vitro to determine their affinity for human A2A A1 receptors. Among the tested compounds, a few displayed nanomolar binding affinities both One particular compound, 11o, showed high activities (hA2A Ki = 13.3 nM; hA1 55 nM) full antagonism IC50 136 98.8 toward Further tests that 11o has low hepatic clearance good pharmacokinetic properties mice, along bioavailability brain plasma...
10.3390/ph15080922
article
EN
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Pharmaceuticals
2022-07-25
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