A5046603969- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Pediatric Pain Management Techniques
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Phonocardiography and Auscultation Techniques
- Blood transfusion and management
- Nuclear Structure and Function
- Mechanical Circulatory Support Devices
- Family and Patient Care in Intensive Care Units
- Central Venous Catheters and Hemodialysis
- RNA Research and Splicing
- DNA Repair Mechanisms
- Hospital Admissions and Outcomes
- Sepsis Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Injury Epidemiology and Prevention
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Anesthesia and Pain Management
- Thermal Regulation in Medicine
- Epilepsy research and treatment
Mayo Clinic in Arizona
2013-2025
Mayo Clinic
2012-2024
WinnMed
2012-2023
Mayo Clinic in Florida
2013-2023
Sanford Health
2020
College of The Bahamas
2020
Committee on Publication Ethics
2020
Children's Center
2015-2018
Creative Commons
2018
Pediatrics and Genetics
2016
The Ran guanosine triphosphatase (GTPase) controls nucleocytoplasmic transport, mitotic spindle formation, and nuclear envelope assembly. These functions rely on the association of Ran-specific exchange factor, RCC1 (regulator chromosome condensation 1), with chromatin. We find that binds directly to mononucleosomes histones H2A H2B. utilizes these bind Xenopus sperm chromatin, binding nucleosomes or stimulates catalytic activity RCC1. propose docking H2A/H2B establishes polarity Ran-GTP...
Background We undertook this study to evaluate the efficacy of an on-table extubation protocol and assess magnitude benefits when implemented as a routine practice in developing country. Methods This prospective observational at single tertiary care referral hospital was designed determine applied children undergoing cardiac surgery world. The included 226 patients who were 1 month 18 years age (including grown-up congenital heart disease [GUCHD] patients). Patients with RACHS score ≥ 4,...
RCC1, the only known guanine-nucleotide exchange factor for Ran GTPase, is an approximately 45-kD nuclear protein that can bind chromatin. An important question concerns how RCC1 traverses envelope. We now show not exported readily in interphase cells and import of into nucleoplasm extremely rapid. Import proceed by at least two distinct mechanisms. The first a classic pathway mediated basic residues within NH(2)-terminal domain (NTD) RCC1. This dependent upon both preexisting gradient...
Each year millions of young children undergo procedures requiring sedation or general anesthesia. An increasing proportion the anesthetics used are provided to optimize diagnostic imaging studies such as magnetic resonance imaging. Concern regarding neurotoxicity sedatives and has prompted US Food Drug Administration change labeling sedative agents warning against repeated prolonged exposure in children. This review aims summarize risk anesthesia with an emphasis on anesthetic-related...
Background Perioperative arterial cannulation in children is routinely performed. Based on clinical observation of several complications related to femoral lines, the authors performed a larger study further examine complications. The aimed (1) describe use patterns and incidence major short-term associated with for perioperative monitoring children, (2) rates by anatomical site age category patient. Methods examined retrospective cohort pediatric patients (age less than 18 yr) undergoing...
Ran-binding protein 3 (RanBP3) is an approximately 55-kDa that functions as a cofactor for Crm1-mediated nuclear export. RanBP3 stimulates export by enhancing the affinity of Crm1 Ran.GTP and cargo. However, important additional this may exist. We now report associates with Ran-specific guanine nucleotide exchange factor, regulator chromosome condensation 1 (RCC1). This interaction was stimulated addition Ran; moreover, Ran.GDP, Ran.GTP, Ran without could all stimulate complex formation...
Ineffective and inefficient patient transfer processes can increase the chance of medical errors. Improvements in such are high-priority local institutional national safety goals. At our institution, nonintubated postoperative pediatric patients first admitted to postanesthesia care unit before PICU. This quality improvement project was designed improve process from operating room (OR) PICU.After direct observation baseline process, we introduced a structured, OR-PICU for orthopedic spinal...
Head injuries are the leading cause of death among cyclists, 85 % which can be prevented by wearing a bicycle helmet. This study aims to estimate incidence pediatric bicycle-related in Olmsted County and assess differences between those helmets vs. not. County, Minnesota residents 5 18 years age with diagnostic code consistent an injury associated use January 1, 2002, December 31, 2011, were identified. Incidence rates calculated standardized sex distribution 2000 US white population. Type...
Noise and excessive, unwanted sound in the Pediatric Intensive Care Unit (PICU) is common has a major impact on patients' sleep recovery. Previous research focused mostly absolute noise levels or included only staff as respondents to acknowledge causes of plan for its reduction. Thus far, suggested interventions have not ameliorated noise, it continues serve barrier In addition surveying PICU providers through internet-based software, families were evaluated in-person interviews utilizing...
Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are the leading causes of transfusion-related fatalities. While these pulmonary complications (TRPCs) have been well detailed in adults, their burden pediatric subsets remains poorly defined. We sought to delineate incidence epidemiology TRPCs after intraoperative blood product transfusion.In this retrospective cohort study, we evaluated all consecutive patients receiving transfusions during...
No risk prediction model is currently available to measure patient's probability for readmission the pediatric intensive care unit (PICU). This retrospective case-control study was designed assess applicability of an adult score (Stability and Workload Index Transfer [SWIFT]) create a version (PRediction Of PICU Early Readmissions [PROPER]).Eighty-six unplanned early (<48 hours) readmissions from January 07, 2007, June 30, 2014, were compared with 170 random controls. Patient-...
Arthrogryposis syndromes are a heterogeneous group of disorders characterized by congenital joint contractures often requiring multiple surgeries during childhood to address skeletal and visceral abnormalities. Previous reports suggest that these children have increased perioperative risk, including hypermetabolic events discrete from malignant hyperthermia, difficult airway management, isolated IV line placement. We sought compare with arthrogryposis multiplex congenita (AMC) versus the...
To evaluate the effect of acute lung injury on frequency spectra breath sounds, we made serial acoustic recordings from nondependent, midlung and dependent regions both lungs in ten 35- to 45-kg anesthetized, intubated, mechanically ventilated pigs during development induced with intravenous oleic acid prone or supine position. Oleic injections rapidly produced severe derangements gas exchange mechanical properties lung, an average increase venous admixture 16 ± 12 62 16% (P < 0.01), a...
Propylene glycol (PG) is a solvent commonly used in medications that, while benign at low doses, may cause toxicity adults and children high doses. We describe case the physiologic sequelae of propylene manifested critically ill adolescent male with refractory myoclonic status epilepticus aggressively treated multiple PG-containing (lorazepam, phenobarbital, pentobarbital)—all within accepted dosing guidelines total daily PG exposure previously recognized to be safe. Hemodynamic measurements...