A5074841575- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- Pharmacological Effects and Assays
- Behavioral and Psychological Studies
- Psychedelics and Drug Studies
- Forensic Toxicology and Drug Analysis
- Stress Responses and Cortisol
- Treatment of Major Depression
- Olfactory and Sensory Function Studies
- Mast cells and histamine
- Neurogenesis and neuroplasticity mechanisms
- Behavioral Health and Interventions
- Pain Mechanisms and Treatments
- Neuroscience and Music Perception
- Stroke Rehabilitation and Recovery
- Mental Health Research Topics
- Neurobiology and Insect Physiology Research
- Diet and metabolism studies
- Sexual Assault and Victimization Studies
University of Colorado Denver
2013-2024
University of Colorado System
2021
University of Denver
2019
Wake Forest University
2007-2017
Drexel University
2017
University of Maryland, Baltimore
2010-2015
University of Baltimore
2014
United States University
2014
Medical University of South Carolina
2005
The mesolimbic dopamine system is believed to be a pathway that processes rewarding information. While previous studies have also implicated general role for in punishment and its avoidance, the precise nature of subsecond release during these phenomena remains unknown. Here, we used fast-scan cyclic voltammetry investigate whether events nucleus accumbens encode cues predicting avoidance behavior maintained signaled footshock procedure. In this task, rats could initiate an response by...
Abstract Recent evidence suggests that the hypocretin–orexin system participates in regulation of reinforcement processes. The current studies examined extent to which hypocretin neurotransmission regulates behavioral and neurochemical responses cocaine, food reinforcement. These used a combination fixed ratio, discrete trials, progressive ratio threshold self‐administration procedures assess whether 1 receptor antagonist, SB‐334867, reduces cocaine rats. Progressive sucrose were also...
Homer proteins are involved in the functional assembly of postsynaptic density at glutamatergic synapses and implicated learning, memory drug addiction. Here, we report that Homer1 ‐knockout ( ‐KO) mice exhibit behavioral neurochemical abnormalities consistent with animal models schizophrenia. Relative to wild‐type mice, ‐KO exhibited deficits radial arm maze performance, impaired prepulse inhibition, enhanced ‘behavioral despair’, increased anxiety a novel objects test, reactivity...
Homer proteins are integral to the assembly of regulating glutamate signaling and synaptic plasticity. Constitutive Homer2 gene deletion [knock-out (KO)] rescue with adeno-associated viral (AAV) transfection Homer2b was used demonstrate importance in neuroplasticity produced by repeated ethanol (EtOH) administration. KO mice avoided drinking high concentrations EtOH did not develop place preference or locomotor sensitization after The deficient behavioral plasticity paralleled a lack...
Homer1 mutant mice exhibit behavioral and neurochemical abnormalities that are consistent with an animal model of schizophrenia. Because the gene encodes both immediate early (IEG) constitutively expressed (CC) products, we used local infusion adeno-associated viral vectors carrying different transcriptional variants into prefrontal cortex (PFC) to distinguish between roles for IEG CC isoforms in “schizophrenia-like” phenotype mice. PFC overexpression isoform Homer1a reversed genotypic...
Significance A central tenet of economics is that as the price a commodity increases, its demand goes down because individuals choose to buy less. Mounting evidence supports role for neuromodulator dopamine in representing subjective value. We investigated valuation by presenting rats with reward across range prices. showed concentration decreased and increasing release using optogenetic manipulations-altered sensitivity. Increasing prior delivery made animals more sensitive price, whereas...
REVIEW article Front. Neurosci., 07 June 2013Sec. Decision Neuroscience Volume 7 - 2013 | https://doi.org/10.3389/fnins.2013.00096
Benzodiazepines make up a class of psychoactive drugs that act as allosteric co-activators the inhibitory GABAA receptor. These are useful for treatment several psychiatric disorders but also hold considerable abuse liability. Despite common use and misuse benzodiazepines, mechanisms through which these exert their reinforcing effects remain incompletely understood. Transient phasic increases in dopamine levels believed to play an important role defining properties abuse, we recently...
Benzodiazepines are commonly prescribed anxiolytics that pose abuse liability in susceptible individuals. Although it is well established all drugs of increase brain dopamine levels, and benzodiazepines allosteric modulators the GABA<sub>A</sub> receptor, remains unclear how they alter release. Using vivo fast-scan cyclic voltammetry, we measured diazepam-induced changes frequency amplitude transient release events. We found diazepam concurrently increases decreases events awake freely...