Polymicrobial wound infections often require high dosages of antibiotics and fungicides. However, prolonged antimicrobial therapies are associated with potential systemic side effects an increased risk the development drug-resistant microbes. With this focus, we aimed at developing chitosan bandages loaded drug (ciprofloxacin fluconazole) nanoparticles for a sustained slow release drugs. The particle sizes prepared ciprofloxacin- flucanazole-loaded fibrin were observed to be 132 ± 16 175 17...

Diabetes remains the commonest cause of blindness in working age population UK, but little information exists about individuals who are currently losing sight from this cause. We determined current incidence (1998-2000) Newcastle Health District and clinical characteristics these patients.Data were collected for 1998-2000 Royal National Institute Blind Liaison Office Ophthalmology Department. The Clinic notes on each individual retrieved to verify details, including previous eye diagnosis,...

Abstract Aims Diabetic retinopathy has long been regarded as the commonest preventable cause of blindness in working age population. The aim was to determine if consistent annual screening for treatable decreased incidence new blindness. Methods We collated causes a 5‐year period between 2001 and 2005 16‐ 64‐year group district that had operated systematic retinal diabetes since 1986. Results found be second blindness, with optic atrophy being Newcastle District. This differs from national...

Tumour-induced osteomalacia (TIO) is a rare disorder characterized by hypophosphataemic caused small mesenchymal tumours secreting fibroblast growth factor 23 (FGF 23). The most difficult part in the management of these patients localization causing TIO.We describe utility Gallium (Ga)-68 DOTANOC PET/CT TIO.The study was conducted single tertiary referral university teaching hospital India. Ten with TIO who underwent Ga-68 from time period 2009 to 2014 were included this study. Their...

Atypia of undetermined significance or follicular lesion (AUS/FLUS) The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has emerged as the most controversial category because its heterogeneity and inconsistent reporting. There is a definite paucity in data available from Indian subcontinent about outcome nodules carrying III IV diagnoses.The primary objective our study was to determine malignancy rate categories nodules. secondary objectives were predictive value BRAFV600E...

OBJECTIVE—The value of microalbuminuria (MA) in predicting renal disease and premature mortality longer duration type 1 diabetes is unclear. RESEARCH DESIGN AND METHODS—We followed 135 patients with long-standing (>30 years’ duration) over a 7-year period, recording albuminuria other clinical variables. Vital status was ascertained cause death recorded. RESULTS—A total 27 (20%) died during the follow-up period. Patients MA (10 30, 33.3%) or proteinuria (5 6, 83.3%) at initial...

Introduction: The prevalence of diabetes is increasing worldwide resulting in foot complications, which leads to poor quality life and increased cost living. Aim: main aim this study was find out the complications diabetic patients analyze underlying etiology. Methodology: A retrospective carried podiatry Department Amrita Institute Medical Sciences, Kerala among 277 with recent recurrent complications. Results: Systemic hypertension (76.89%) has been found be one major risk factor...

There has been no previous study that investigated the effect of a low glycemic index (LGI) diet with local recipes South Indian cuisine on body fat composition using dual-energy X-ray absorptiometry (DXA). Truncal obesity associated risk metabolic disorders and cardiovascular diseases.The aim this was to examine GI control in people type 2 diabetes India.This prospective randomized controlled conducted over period 24 weeks. A total 40 participants were recruited from Department...

Abstract Background The present study was designed to evaluate the metabolic profile, cardiovascular risk factors and quality of life in children with congenital adrenal hyperplasia (CAH) compare it age- sex-matched controls. Methods Fifty-two patients aged 3–21 years classic CAH due 21-hydroxylase deficiency were included study. Metabolic profiling done for 36 cases compared 28 healthy Quality assessed all 52 their parents using a validated Pediatric Life Inventory (PedsQL) questionnaire...

Background: Inflammation is considered as a predictor of cardiovascular diseases in type 2 diabetes mellitus. No previous studies have investigated the effect low glycemic index (LGI) recipes South Indian cuisine on risk factors disease patients with diabetes. Aim: The aim this randomized controlled trial was to evaluate improvement and blood glucose control, diabetes, after intervention Kerala cuisine, from locally available whole grain cereals, index. Method: This prospective study that...

In patients taking inhaled corticosteroids the biochemical detection of a suppressed hypothalamicpituitary-adrenal axis is well documented.1 2 Fluticasone propionate most potent glucocorticoid,3 4 and adrenocortical insufficiency has been reported in 12% on high dose fluticasone.1 5 The incidence addisonian crises lower, but may occur during intercurrent illness or after reduction withdrawal.5 Itraconazole an orally active antifungal triazole that inhibits cytochrome P450 dependent CYP3A4...

To establish a clinically efficient, cost-effective quality assurance programme as part of routine retinopathy screening service.The operation system an ongoing retinal service is described. A random selection 12% images all people reported to have and 2% no are re-graded by consultant ophthalmologist. Entry the two sets data into purpose-designed excel spreadsheet allows automated calculation sensitivity specificity.The results from August 2001 July 2003 reported. Out 8351 episodes, 498...

Relative adrenal insufficiency (RAI) is common in compensated and decompensated chronic liver disease the presence of sepsis. This study was performed to find out prevalence RAI cirrhotic patients presenting with hepatic encephalopathy variceal bleeding without any evidence infection.The prospectively included 75 signs decompensation. The short Synacthen test (SST) on all after ruling infection. Patients positive blood, urine, sputum, ascitic pleural fluid cultures or infection chest X-ray...

Fasting is observed as a religious custom in various forms across the globe. Among them, Ramadan fasting very common and widely practiced. People with diabetes observe or without obtaining medical advice. Uncontrolled appears to be risk factor for COVID-19 infection its poorer outcomes. during challenging people diabetes. This year, background of made it difficult both patients health care workers effectively manage complications Ramadan. Because lack sufficient evidence, clinicians were...

A 30-year-old male with cerebral palsy and motor impairment presented right femur fracture. He had gradually worsening mobility contractures of all extremities for the preceding 5 years. Evaluation showed multiple vertebral femoral fractures, severe osteoporosis, a large parathyroid adenoma, parathormone (PTH) exceeding 2500 pg/mL. Because poor general health high anesthetic risk, parathyroidectomy was deemed impractical. Ultrasound-guided radiofrequency ablation (RFA) helped achieve 50%...

Klinefelter syndrome (KFS) is the commonest chromosomal abnormality, yet remains largely underdiagnosed due to its varied clinical presentation. This study was done understand spectrum in our population.We intended characteristics of children and adults with KFS population. We also desired identify any special features variants.Forty-four patients karyotype diagnosis during time period 2007-2015 were included this retrospective study. Clinical details hormonal profile obtained from hospital...

Medullary thyroid carcinoma (MTC), being an aggressive disease, requires meticulous follow-up and multidisciplinary management. The clinical presentation, management, outcome of MTC varies among different populations.An audit was conducted to evaluate the demography, in a tertiary care center South India.A retrospective analysis data from hospital records patients with treated at our 2004 2019.All analyses were performed SPSS software (version 16).Among 82 (M 42, F 40), mean age 42.07 years...

Grading system uses A, B, C, or E to show the evidence level that supports each recommendation.• A -Clear from well-conducted, generalizable randomized controlled trials are adequately powered.

Most of the information on remission related factors in Grave's disease are derived from Western literature. It is likely that there may be additional prognostic and differences postdrug treatment course India.To study which predict remission/relapse patients South India. Also to establish if technetium (Tc) uptake has a role predicting remission.Records 174 with clinical, biochemical, scintigraphic criteria consistent disease, seen our Institution between January 2006 2014 were analyzed....

To study the health-related quality of life (HRQoL) in pediatric onset Type 1 diabetes mellitus (TIDM) state Kerala India.Diabetes specific HRQoL was determined 107 subjects with T1DM less than 21 years using Pediatric Quality Life Inventory (PedsQL) 3.2 questionnaire which 69 also completed PedsQL 4.0 generic questionnaire. The parents these patients proxy scoring compared control population without diabetes.Mean age 8.2 ± 4.6 and mean duration 5.6 years. median HbA1c 8.7% (72 mmol/mol)....