A5051921900- Retinal Development and Disorders
- CRISPR and Genetic Engineering
- Otolaryngology and Infectious Diseases
- Burn Injury Management and Outcomes
- Head and Neck Surgical Oncology
- Neuroinflammation and Neurodegeneration Mechanisms
- Ophthalmology and Eye Disorders
- RNA regulation and disease
- Sinusitis and nasal conditions
- Genomics and Rare Diseases
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Ocular and Foreign Body Injuries
- Facial Trauma and Fracture Management
- Cerebral Venous Sinus Thrombosis
- Streptococcal Infections and Treatments
- Fungal Infections and Studies
- Thyroid Disorders and Treatments
- Antifungal resistance and susceptibility
University of Washington
2020-2024
Washington State University Spokane
2023-2024
Georgia Highlands College
2023-2024
Washington State University
2024
Regenerative neuroscience aims to stimulate endogenous repair in the nervous system replace neurons lost from degenerative diseases. Recently, we reported that overexpressing transcription factor Ascl1 Müller glia (MG) is sufficient MG regenerate functional adult mouse retina. However, this process inefficient, and only a third of Ascl1-expressing generate new neurons. Here, test whether proneural factors Atoh1/7 class can further promote regenerative capacity MG. We find combination...
Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that this process can be induced mouse MG, after injury, by transgenic expression of the proneural transcription factor Ascl1 and HDAC inhibitor TSA. However, new neurons are generated only from a subset MG. Identifying factors limit Ascl1-mediated MG reprogramming could make more efficient. In study, we test whether injury-induced STAT activation hampers ability to reprogram into neurons....
Phasing genetic variants is essential in determining those that are potentially disease-causing. In autosomal recessive inherited retinal diseases (IRDs), reclassification of uncertain significance (VUS) can provide a diagnosis indeterminate compound heterozygote cases. We report four cases which familial co-segregation demonstrated VUS resided trans to known pathogenic variant, concert with other supporting criteria, led the likely pathogenic, thereby providing each case. also demonstrate...
A 16-year-old black female presented with a 4-month history of significant proptosis and diplopia in the setting diagnosed Graves disease. The patient underwent 8 infusions teprotumumab. She had migraines that were resolved treatment. There was also dramatic improvement her proptosis. authors present first reported case successful teprotumumab treatment an adolescent patient, describing outcomes proposing mechanism for transient side effects.
A 79-year-old female presented to the emergency department for sudden-onset ocular pain, edema, and erythema around her left eye. She also had a left-sided migraine frontal fullness 2 weeks. attentive care diagnosis of orbital cellulitis prompt recognition necrotizing fasciitis. Wound cultures were positive over 5 strains bacteria in addition
A 28-year-old male presented to the emergency room suffering an ocular burn injury from a welding rod. Given mechanism of injury, severe delayed adnexa occurred, requiring enucleation, partial exenteration superior orbit, and extensive reconstruction. Histopathology affected tissue was analyzed. This is first report that details clinical course patient with high amperage low voltage electrical injury.