Abstract Background Nerve injuries are debilitating, leading to long-term motor deficits. Remyelination and axonal growth supported enhanced by factor cytokines. Combination of nerve guidance conduits (NGCs) with adipose-tissue-derived multipotent mesenchymal stromal cells (AdMSCs) has been performing promising strategy for regeneration. Methods 3D-printed polycaprolactone (PCL)-NGCs were fabricated. Wistar rats subjected critical sciatic damage (12-mm gap) divided into sham, autograft, PCL...

<title>Abstract</title> Background Contrast-induced acute kidney injury (CI-AKI) remains a clinically relevant complication, with uncertainties regarding its true epidemiology, pathophysiology, optimal diagnostic methods, and preventive strategies. As the global volume of contrast-enhanced imaging procedures continues to rise, there is critical need refine early detection prevention approaches. Methods This prospective, randomized clinical trial included patients peripheral artery disease...

Background Peripheral artery disease (PAD) can develop into critical limb ischemia (CLI), which is characterized by resting pain at rest, ulcerations, or gangrene, with a high risk of amputation. The optimum course treatment this point arterial revascularization, although has significant financial cost and not always feasible successful in reducing pain, healing ulcers, preventing amputations. In situations where traditional alternatives for treating PAD have been exhausted, recent...

Clinical experience for peripheral arterial disease treatment shows poor results when synthetic grafts are used to approach infrapopliteal segments. However, tissue engineering may be an option yield surrogate biocompatible neovessels. Thus, biological decellularized scaffolds could provide natural architecture use in engineering, the absence of ideal autologous veins reduces surgical options. The goal this study was evaluate different chemical induced decellularization protocols inferior...

BackgroundCardiovascular diseases remain leaders as the major causes of mortality in Western society. Restoration circulation through construction bypass surgical treatment is regarded gold standard peripheral vascular diseases, and grafts are necessary for this purpose. The great saphenous vein often not available synthetic have their limitations. Therefore, new techniques to produce alternative been developed and, sense, tissue engineering a promising provide biocompatible grafts. This...

Reticular veins are subdermal located in the lower limbs and mainly associated with aesthetic complaints. Although sclerotherapy is treatment of choice for reticular limbs, no consensus has been reached regarding to optimal sclerosant.To compare efficacy safety 2 sclerosants used treat veins: 0.2% polidocanol diluted 70% hypertonic glucose (HG) (group 1) vs 75% HG alone 2).Prospective, randomized, triple-blind, controlled, parallel-group clinical trial patients randomly assigned a 1:1 ratio...

Resumo Contexto O tromboembolismo venoso (TEV) é uma doença silenciosa e potencialmente letal que acomete parcela importante dos pacientes hospitalizados. Com alta morbimortalidade elevado custo financeiro para o sistema de saúde, TEV pode ser prevenido com uso da profilaxia, já estabelecida pela literatura. No mundo real, a profilaxia possui média adequação inferior 50%. Objetivos Definir perfil epidemiológico do doente em um hospital universitário taxa no referido serviço, além determinar...

Maintaining a permissive microenvironment is essential for adequate nerve regeneration. Cell-based therapy has the potential based cell replacement and promotion of axonal growth. The adipose tissue derived mesenchymal stromal cells (Ad-MSC) attract interest because neuroregenerative anti-inflammatory properties. aim this study was to evaluate effects canine murine Ad-MSC transplantation on sciatic regeneration.Forty Wistar rats were divided randomly into: control group - CG (n=8);...

MicroRNAs (miRNAs) are non-coding RNAs involved in the regulation of gene expression associated with cell differentiation, proliferation, adhesion, and important biological functions such as inflammation. miRNAs play roles pathogenesis chronic degenerative disorders including cardiovascular diseases. Understanding influence their target genes can effectively streamline identification key biologically active pathways that development vascular grafts through tissue engineering blood vessels....

Objectives Compare the efficacy and safety of fibrin gel to 8% papain for wound dressing venous ulcers. Method Patients with chronic ulcers were randomly assigned one in three groups: Group 1—fibrin gel; 2—8% 3—carbopol (control). seen every 15 days during 2 months, verifying reduction ulcer area, local infection, exudation, epithelization. All serious or nonserious adverse events recorded. Results Fifty-five patients (total 63 ulcers) distributed groups (G1 = 21; G2 19; G3 23). No patient...

The prevalence of chronic venous disease is high and occurs more frequently in females. According to the clinical, etiological, anatomical, pathological classification (CEAP) definition, reticular veins are included C1 class mainly associated with aesthetic complaints. Several invasive techniques used for treatment, including mini phlebectomy, laser ablation, radiofrequency ablation. However, a wide range sclerosing agents may serve as minimally alternatives, promoting chemical sclerosis...

Diabetics are at 5-15 times greater risk of developing peripheral arterial disease (PAD) and few studies have compared factors distribution severity changes in diabetics with non-diabetics.To compare angiographic between diabetic non-diabetic patients advanced PAD correlate them factors.A retrospective cross-sectional study was conducted consecutive undergoing lower limb arteriography for (Rutherford 3-6) using TASC II Bollinger et al. scores. Exclusion criteria were upper angiographies,...

The endovenous laser ablation (EVLA) of the insufficient saphenous vein has similar results to open conventional surgery, but less morbidity. echo-guided polidocanol foam sclerotherapy technique been used for same purpose. combined techniques may play a role more severe diseases, such as those with varicose ulcers. An EVLA device (called VELAS) developed in Optics and Photonics Research Center USP-São Carlos agreement FMB-UNESP. In this study, we present preliminary VELAS (MMO 980nm diode)...

Kassabach-Merritt syndrome is a combination of capillary hemangioma and thrombocytopenia that predisposes to bleeding with petechiae, ecchymosis spontaneous bruising. Treatment generally started corticosteroids, interferon alpha or chemotherapy. We present the case child (aged 1 year 9 months) giant hemangioma, from root thigh knee, thrombocytopenia. was without improvement, then intra-tumor cutaneous appeared spontaneously. The patient's clinical condition precluded prescription vincristine...

Resumo A trombocitopenia induzida por heparina é uma complicação grave da terapêutica anticoagulante com e está associada à formação de anticorpos antifator IV plaquetário. Costuma surgir a partir do quinto dia tratamento, queda pelo menos 50% contagem plaquetária. Em decorrência ativação plaquetária concomitante, pode ocorrer quadro trombose, venosa ou arterial, repercussões clínicas graves. Apresentamos um caso paciente portador síndrome anticorpo antifosfolípide, oclusão arterial aguda,...

Agenesis of the inferior vena cava (IVC) has been described in less than 1% population; a rare occurrence caused by embryonic abnormalities. Its correlation with deep vein thrombosis (DVT) is certainly underestimated, since this change hard to detect using ultrasound. The aim article report case 41-year-old female patient pain and edema up top right thigh after plastic surgery. Bilateral venous duplex ultrasound revealed bilateral DVT involving iliac-femoral-popliteal distal segments. Venous...

Endovascular aneurysm repair (EVAR) is already considered the first choice treatment for abdominal aortic aneurysms (AAA). Several different strategies have been used to address limitations arterial access caused by unfavorable iliac artery anatomy. The aim of this report illustrate advantages and each option present results using internal endoconduit technique difficulties involved.

Purpose: To investigate the ultrastructural characteristics and analysis of residual DNA in scaffold models, produced with decellularized vena cava an experimental model rabbits. Methods: Three groups were created for analysis: group 1 - control, consisting samples natura; 2 SD, vein fragments submitted to 2% sodium deoxycholate decellularization by shaking (160rpm Shaker News Brunswick Scientific®) hour at controlled temperature shaker 37°C; 3 SDS, 1% dodecyl sulfate under same previous...