A5044650290- Biosensors and Analytical Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced biosensing and bioanalysis techniques
- Single-cell and spatial transcriptomics
- 3D Printing in Biomedical Research
- Advanced Biosensing Techniques and Applications
- Electrowetting and Microfluidic Technologies
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Micro and Nano Robotics
- Microfluidic and Bio-sensing Technologies
- Extracellular vesicles in disease
- Viral Infectious Diseases and Gene Expression in Insects
National University of Singapore
2017-2022
An ultrahigh-throughput single-cell miRNA assay is developed by a continuous-flow microfluidic process employing isothermal amplification to amplify the target signal.
Light-directed forces have been widely used to pattern micro/nanoscale objects with precise control, forming functional assemblies. However, a substantial laser intensity is required generate sufficient optical gradient move small object in certain direction, causing limited throughput for applications. A high-throughput light-directed assembly demonstrated as printing technology by introducing gold nanorods induce thermal convection flows that microparticles (diameter = 40 µm several...
Drop-PEARL enables rapid screening and isolation of virus-neutralizing antibody secreting cells for high-throughput therapeutic discovery.
Cell nucleocytoplasmic profiles of microRNAs (miRNAs) are critical to determining a single cell's essential functionalities, such as cellular transcription, nucleus export and degradation, which gives comprehensive view processes. Despite the importance addressing heterogeneity, challenge high-throughput screening remains. Although droplet-based approach was developed for single-cell miRNA assays, quantifying with high sensitivity indicate heterogeneity In this study, nanoplasmon-enhanced...
Bacterial cellulose (BC), a renewable type of cellulose, has been used in the manufacture foods, cosmetics, and biomedical products. To produce BC, high-throughput single-bacterium measurement is necessary to identify functional bacteria that can BC with sufficient amount desirable morphology. In this study, continuous-flow intelligent optofluidic device was developed enable profiling BC. Single were incubated agarose hydrogel particles varied densities structures. An convolutional neural...