A5023558837- Vasculitis and related conditions
- Intracranial Aneurysms: Treatment and Complications
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Cervical and Thoracic Myelopathy
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Head and Neck Cancer Studies
- Spinal Fractures and Fixation Techniques
- Autophagy in Disease and Therapy
- T-cell and B-cell Immunology
- interferon and immune responses
- Immune Cell Function and Interaction
- Swearing, Euphemism, Multilingualism
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Reconstructive Surgery and Microvascular Techniques
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Cardiac, Anesthesia and Surgical Outcomes
- Spinal Cord Injury Research
- Oropharyngeal Anatomy and Pathologies
- Salmonella and Campylobacter epidemiology
- Hip and Femur Fractures
University of Ottawa
2020-2023
Tulane University
2009-2018
Gene Therapy Laboratory
2011
University of New Orleans
2009
Recent studies have implicated multipotential mesenchymal stem cells (MSCs) as an aid to breast cancer cell proliferation and metastasis, partly a result of the MSCs secretome. As tumor gets beyond 2 mm in diameter, stromal could undergo starvation due lack sufficient nutrients solid microenvironment. In this study, we investigated survival mechanisms used by stressed cancers. We serum-deprived (SD-MSCs) MCF-7 model system with hypothesis that nutrient-deprived core utilize for supporting...
OBJECTIVE We report a rare case of internal carotid artery pseudoaneurysm owing to rhinocerebral mucormycosis and review 40 reported cases from 1980 present. CLINICAL PRESENTATION A 38-year-old Caucasian man presented with 3-day history headache, diplopia, numbness in the distribution left ophthalmic maxillary branches trigeminal nerve. complete cavernous syndrome was discovered upon neurological examination. Magnetic resonance imaging scans revealed an inflammatory process involving...
Objectives/Hypothesis To perform a subset analysis of faith‐ and community‐based screening events to further identify at‐risk populations for head neck cancer in hopes focusing efforts. Study Design Prospective cohort study. Methods Three hundred fifty‐three individuals (n=353) presented community self‐selected screenings. A subgroup on risk factors the development poor overall prognosis was performed. Subgroups analyzed were screened at church‐affiliated events, social or outreach homeless...
Overall prognosis for osteosarcoma (OS) is poor despite aggressive treatment options. Limited access to primary tumors, technical challenges in processing OS tissues, and the lack of well-characterized cell cultures has hindered our ability fully understand properties tumor initiation progression. In this study, we have isolated characterized derived from four central high-grade human samples. Furthermore, used study role CD49f Recent studies implicated stemness multipotency both cancer stem...
This is a case report of 48-year-old man with multiple transient ischemic attacks and known hypoplastic right vertebral artery (VA) who presented after syncopal event while turning his head to the left. The objective this study demonstrate necessity proper diagnosis management cerebrovascular pathology including imaging surgical intervention in patients anatomical anomalies. was conducted at Massachusetts, United States America. Our patient's history significant for VA stenotic segment C3-C4...
Objective The National Surgical Quality Improvement Program (NSQIP) calculator was created to improve outcomes and guide cost‐effective care in surgery. Patients with head neck cancer (HNC) undergo ablative free flap reconstructive surgery prolonged postoperative courses. Methods A case series chart review performed on 50 consecutive patients HNC undergoing from October 2014 March 2016 at a tertiary center. Comorbidities intraoperative variables were collected. Predicted length of stay...
XIAP is an endogenous inhibitor of cell death and inactivating mutations are responsible for X-linked lymphoproliferative disease (XLP-2) primary immunodeficiency, but the mechanism(s) behind these contradictory outcomes have been unclear. We report that during infection macrophages dendritic cells with various intracellular bacteria, restricts secretion IL-1β promotes increased activation NFκB JNK which results in elevated IL-6 IL-10. Poor by Xiap-deficient antigen presenting leads to poor...
Inflammasome signaling results in cell death and release of cytokines from the IL-1 family, which facilitates control over an infection. However, some pathogens such as Salmonella typhimurium (ST) activate various innate immune pathways, including inflammasomes, yet evade these mechanisms, resulting a chronic Here we investigated inflammasome induced by acute isolates ST obtained different organs. We show that isolated infected mice during phase displays increased potential to signaling,...
Brown-Séquard syndrome, while uncommon, is a neurological condition that classically results from the hemisection of spinal cord as result penetrating injury to cord. We present reported case blunt trauma causing high-energy cervical burst fracture/dislocation with significant signal change producing syndrome. In this case, fracture at level C5 obtained motor vehicle accident led damage left-sided lateral thalamic tract, descending cortical tracts, and ascending dorsal column. This unique...
Rhinocerebral mucormycosis (RCM) is a rare opportunistic infection caused by fungi from the Mucoraceae family. This fulminant disease typically affects individuals with poorly controlled diabetes or immunological disorders; however, no underlying condition have also been known to contract RCM. Due rapid progression of this disease, early diagnosis followed prompt medical and surgical intervention crucial in achieving positive outcome. The authors describe successful management an RCM patient...
Abstract Osteosarcoma (OS) is one of the most prolific forms cancer among adolescents, resulting in a severe decrease life expectancy unless detected early. Though several previous studies have suggested various tumor-initiating properties osteosarcoma, major limitations for understanding been observed due OS's restrictive ability to expand vivo models. In this study, we are reporting use primary osteosarcoma cells characterizing tumor initiating property. Human OS samples were collected...
Abstract Salmonella is a bacterial pathogen that typically causes acute infections, however, typhoid strains may chronically persist in an asymptomatic state after the infection has been resolved. Inflammatory cell death plays key role controlling infections and inflammasomes are innate signalling complex respond to infection. Inflammasomes be triggered by recognition of associated molecular patterns such as virulence factors, including flagella type III secretion systems Salmonella....