A5003751848- Multiple Myeloma Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Protein Degradation and Inhibitors
- Cardiac Arrhythmias and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Chemokine receptors and signaling
- Cardiac electrophysiology and arrhythmias
- Peroxisome Proliferator-Activated Receptors
- Pediatric Urology and Nephrology Studies
- Bone Metabolism and Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Bone health and treatments
- Hematopoietic Stem Cell Transplantation
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Antiplatelet Therapy and Cardiovascular Diseases
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Glycosylation and Glycoproteins Research
- Metabolomics and Mass Spectrometry Studies
The University of Adelaide
2014-2024
South Australian Health and Medical Research Institute
2019-2024
Uppsala University
2021-2022
Örebro University
2022
Maria Cecilia Hospital
2022
Laboratoire Informatique d'Avignon
2022
University of Modena and Reggio Emilia
2021-2022
Basil Hetzel Institute
2014-2021
Queen Elizabeth Hospital
2017
Queen Elizabeth Hospital
2017
The androgen receptor (AR) is the key oncogenic driver of prostate cancer, and despite implementation novel AR targeting therapies, outcomes for metastatic disease remain dismal. There an urgent need to better understand androgen-regulated cellular processes more effectively target dependence cancer cells through new therapeutic vulnerabilities. Transcriptomic studies have consistently identified lipid metabolism as a hallmark enhanced signaling in yet relationship between lipidome remains...
Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are heme-containing enzymes, well known for their antimicrobial activity, released in high quantities by infiltrating immune cells breast cancer. However, the functional importance of presence within tumour microenvironment is unclear. We have recently described a new role peroxidases as key regulators fibroblast endothelial cell functionality. In present study, we investigate first time, ability to promote cancer development progression....
The proteasome inhibitor bortezomib is one of the primary therapies used for haematological malignancy multiple myeloma (MM). However, intrinsic or acquired resistance to bortezomib, via mechanisms that are not fully elucidated, a barrier successful treatment in many patients. Our previous studies have shown elevated expression chemokine receptor CCR1 MM plasma cells newly diagnosed patients associated with poor prognosis. Here, we hypothesised prognosis conferred by is, part, due...
Background and Purpose: Three-dimensional (3D) laparoscopy has been developed in an attempt to address one of the main limitations laparoscopic surgery, which is two-dimensional (2D) vision. Still, data on learning curve during adaptation such technology clinical practice are scarce. In this study, perioperative from initial operations performed by experienced surgeon a 3D setup presented, aiming document any difficulties faced integration vision laparoscopy. Patients Methods: total, 15...
Tumor hypoxia is a major cause of treatment failure for variety malignancies. However, offers opportunities, exemplified by the development compounds that target hypoxic regions within tumors. Evofosfamide (TH-302) prodrug created conjugation 2-nitroimidazole to bromo-isophosphoramide mustard (Br-IPM). When evofosfamide delivered regions, DNA cross-linking effector, Br-IPM, released. This study assessed cytotoxic activity in vitro and its antitumor against osteolytic breast cancer either...
Osteoprotegerin (OPG) is a secreted member of the TNF receptor superfamily, which binds to activator nuclear factor κB ligand (RANKL) and inhibits osteoclast activity bone resorption. Systemic administration recombinant OPG was previously shown inhibit tumor growth in prevent cancer-induced osteolysis. In this study, we examined effect OPG, when produced locally by breast cancer cells located within bone, using mouse model osteolytic cancer. MDA-MB-231-TXSA cells, tagged with luciferase...
Multiple myeloma (MM) disease progression is dependent on the ability of MM plasma cells (PCs) to egress from bone marrow (BM), enter circulation and disseminate distal BM sites. Expression chemokine CXCL12 by stromal crucial for PC retention within BM. However, mechanisms which overcome CXCL12-mediated enable dissemination are poorly understood. We have previously identified that treatment with CCR1 ligand CCL3 inhibits response in cell lines, suggesting CCL3/CCR1 signalling may Here, we...
Summary Expression of myeloperoxidase (MPO), a key inflammatory enzyme restricted to myeloid cells, is negatively associated with the development solid tumours. Activated cell populations are increased in multiple myeloma (MM); however, functional consequences myeloid‐derived MPO within microenvironment unknown. Here, role MM pathogenesis was investigated, and capacity for pharmacological inhibition impede progression evaluated. In 5TGM1‐KaLwRij mouse model myeloma, early stages tumour were...
Abstract Tumor hypoxia is a major cause of treatment failure for variety malignancies. However, also leads to opportunities as demonstrated by the development compounds that target regions within tumors. Evofosfamide hypoxia‐activated prodrug created linking hypoxia‐seeking 2‐nitroimidazole moiety cytotoxic bromo‐isophosphoramide mustard (Br‐ IPM ). When evofosfamide delivered hypoxic tumors, DNA cross‐linking toxin, Br‐ , released leading cell death. This study assessed anticancer efficacy...
The protein SAMSN1 was recently identified as a putative tumor suppressor in multiple myeloma, with re-expression of Samsn1 the 5TGM1/KaLwRij murine model myeloma leading to near complete abrogation intramedullary growth. Here, we sought clarify mechanism underlying this finding. Intratibial administration 5TGM1 cells into KaLwRij mice revealed that had no effect on primary growth, but its expression significantly inhibited metastasis these tumors. Notably, neither vitro nor vivo migration...