A5069969531- Multiple Myeloma Research and Treatments
- Molecular Biology Techniques and Applications
- Chemokine receptors and signaling
- Animal Genetics and Reproduction
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Connective tissue disorders research
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Genomic variations and chromosomal abnormalities
- Glycosylation and Glycoproteins Research
- IL-33, ST2, and ILC Pathways
- Chronic Lymphocytic Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Migraine and Headache Studies
- PI3K/AKT/mTOR signaling in cancer
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
South Australian Health and Medical Research Institute
2015-2024
The University of Adelaide
2014-2024
Dana-Farber Cancer Institute
2023
South Australia Pathology
2008-2014
Centre for Cancer Biology
2010-2014
MRC Laboratory of Molecular Biology
2004-2009
Medical Research Council
2006-2009
Southampton General Hospital
2002
GlaxoSmithKline (United Kingdom)
2001-2002
University of Southampton
2002
Type 2 immunity, which involves coordinated regulation of innate and adaptive immune responses, can protect against helminth parasite infection, but may lead to allergy asthma after inappropriate activation. We demonstrate that il25−/− mice display inefficient Nippostrongylus brasiliensis expulsion delayed cytokine production by T helper cells. further establish a key role for interleukin (IL)-25 in regulating novel population IL-4–, IL-5–, IL-13–producing non–B/non–T (NBNT), c-kit+, FcεR1−...
The large glycoprotein fibrillin is a structural component of elastin-containing microfibrils found in many tissues. Marfan syndrome has been linked to the gene on chromosome 15, but congenital contractural arachnodactyly, which shares some physical features syndrome, 5.
Abstract Purpose: The organic cation transporter OCT-1 mediates active transport of imatinib. We recently showed that low activity is a major contributor to suboptimal response in chronic myeloid leukemia (CML) patients treated with relevance and efflux pumps determining intracellular uptake retention (IUR) dasatinib was assessed. Experimental Design: effect OCT inhibitors on [14C]dasatinib [14C]imatinib IUR compared using peripheral blood mononuclear cells from newly diagnosed CML patients....
Linkage disequilibrium (LD) provides information about positional cloning, linkage, and evolution that cannot be inferred from other evidence, even when a correct sequence linkage map based on more than handful of families become available. We present theory to construct an LD for which distances are additive population-specific maps expected approximately proportional. For this purpose, there is only modest difference in relative efficiency haplotypes diplotypes: resolving the latter into...
Multiple myeloma (MM) is a largely incurable haematological malignancy defined by the clonal proliferation of malignant plasma cells (PCs) within bone marrow. Clonal heterogeneity has recently been established as feature in MM, however, subclonal evolution associated with disease progression not described. Here, we performed whole-exome sequencing serial samples from 10 patients, providing new insights into monoclonal gammopathy undetermined significance (MGUS) and smouldering MM (SMM), to...
Multiple myeloma is a fatal plasma cell malignancy that reliant on the bone marrow microenvironment. The comprised of numerous cells mesenchymal and hemopoietic origin. Of these, macrophages have been implicated to play role in disease progression, angiogenesis, drug resistance; however, establishment remains unknown. In this study, antimyeloma efficacy clodronate-liposome treatment, which globally transiently depletes macrophages, was evaluated well-established C57BL/KaLwRijHsd murine model...
Meeting Reports/Abstracts| June 18 2010 Report of the DNA committee and catalogues cloned mapped genes, markers formatted for PCR polymorphisms (Part 1 27) Subject Area: Genetics R. Williamson; Williamson Search other works by this author on: This Site PubMed Google Scholar A. Bowcock; Bowcock K. Kidd; Kidd P. Pearson; Pearson J. Schmidtke; Schmidtke Ceverha; Ceverha M. Chipperfield; Chipperfield D.N. Cooper; Cooper C. Coutelle; Coutelle Hewitt; Hewitt Klinger; Klinger Langley; Langley...
Netherton syndrome is an autosomal recessive multisystemic disorder characterized by congenital ichthyosiform erythroderma, hair shaft defects and atopy, caused mutations within the human SPINK5 gene. To investigate development of this disease, we have cloned mouse spink5 created mice with a mutated premature stop codon at amino acid R820X, to produce allele that closely mimics point mutation (E827X) in SPINK5. Newborn spink5R820X/R820X develop lethal, severe ichthyosis loss skin barrier...
Multiple myeloma (MM), a hematological malignancy characterized by the clonal growth of malignant plasma cells (PCs) in bone marrow, is preceded benign asymptomatic condition, monoclonal gammopathy undetermined significance (MGUS). Several genetic abnormalities have been identified as critical for development MM; however, number these are also found patients with MGUS, indicating that there other, yet unidentified, factors contribute to onset MM disease. In this study, we identify Samsn1...
Disease progression and relapse in multiple myeloma is dependent on the ability of plasma cells (PC) to reenter circulation disseminate throughout bone marrow. Increased marrow hypoxia associated with increased recirculation PCs. Accordingly, we hypothesized that during chronic hypoxia, activation HIF-2α may overcome retention signal provided by stromal-derived CXCL12, thereby enabling dissemination Here demonstrate upregulates PC CXCL12 expression, decreasing migration toward reducing...
// Craig T. Wallington-Beddoe 1,2,3 , Melissa K. Bennett Kate Vandyke 2,3,4 Lorena Davies 1,2 Julia R. Zebol Paul A.B. Moretti Pitman Duncan Hewett 3,4 Andrew C.W. Zannettino 1,2,3,4,* and Stuart M. Pitson 1,2,3,* 1 Center for Cancer Biology, University of South Australia, Adelaide, Australia 2 SA Pathology, 3 School Medicine, 4 Australian Health Medical Research Institute, * Co-senior authorship this article Correspondence to: Zannettino, email: Pitson, Keywords : myeloma, endoplasmic...
Journal Article A novel fibrillin mutation in the Marfan syndrome which could disrupt calcium binding of epidermal growth factor-like module Get access D.R. Hewett, Hewett * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar J.R. Lynch, Lynch Collagen Genetics Group, Institute Molecular Medicine, John Radcliffe HospitalHeadington, OX3 9DU R. Smith, Smith 1Nuffield Orthopaedic CentreWindmill Road, Headington, Oxford, UK...
Multiple myeloma (MM) is an incurable haematological malignancy characterised by the clonal proliferation of malignant plasma cells within bone marrow. We have previously identified pituitary tumour transforming gene 1 (Pttg1) as a that significantly upregulated in haematopoietic compartment myeloma-susceptible C57BL/KaLwRij mouse strain, when compared with myeloma-resistant C57BL/6 mouse. Over-expression PTTG1 has been associated progression and enhanced proliferative capacity solid...
The proteasome inhibitor bortezomib is one of the primary therapies used for haematological malignancy multiple myeloma (MM). However, intrinsic or acquired resistance to bortezomib, via mechanisms that are not fully elucidated, a barrier successful treatment in many patients. Our previous studies have shown elevated expression chemokine receptor CCR1 MM plasma cells newly diagnosed patients associated with poor prognosis. Here, we hypothesised prognosis conferred by is, part, due...
Summary Elevated expression of the cell adhesion molecule N‐cadherin (cadherin 2, type 1, (neuronal); CDH 2) is associated with poor prognosis in newly‐diagnosed multiple myeloma ( MM ) patients. In this study, we investigated whether targeting represents a potential treatment for ~50% patients elevated N‐cadherin. Initially, stably knocked‐down mouse plasma PC line 5 TGM 1 to assess functional role pathogenesis. When compared 1‐scramble‐sh RNA cells, 1‐ Cdh2 ‐sh cells had significantly...