A5010297697- Genomics and Chromatin Dynamics
- Genomic variations and chromosomal abnormalities
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Lysosomal Storage Disorders Research
- Genetics and Neurodevelopmental Disorders
- Bacillus and Francisella bacterial research
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
- Cancer-related gene regulation
- RNA Research and Splicing
- RNA regulation and disease
- Identification and Quantification in Food
- Insect Resistance and Genetics
- Viral Infections and Outbreaks Research
- Trypanosoma species research and implications
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Microtubule and mitosis dynamics
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
Los Alamos National Laboratory
2007-2021
Center for Integrated Nanotechnologies
2012
Santa Cruz County Office of Education
2003
A*STAR Graduate Academy
2002
Joint Genome Institute
2000-2002
University of California, Davis
2002
Clinique Victor Hugo
1998
Oakland University
1998
Center for Human Genetics
1996-1997
Center for Cancer Research
1996-1997
The human genome holds an extraordinary trove of information about development, physiology, medicine and evolution. Here we report the results international collaboration to produce make freely available a draft sequence genome. We also present initial analysis data, describing some insights that can be gleaned from sequence.
The first chordates appear in the fossil record at time of Cambrian explosion, nearly 550 million years ago. modern ascidian tadpole represents a plausible approximation to these ancestral chordates. To illuminate origins chordate and vertebrates, we generated draft protein-coding portion genome most studied ascidian, Ciona intestinalis . contains ∼16,000 genes, similar number other invertebrates, but only half that found vertebrates. Vertebrate gene families are typically simplified form ,...
The compact genome of Fugu rubripes has been sequenced to over 95% coverage, and more than 80% the assembly is in multigene-sized scaffolds. In this 365-megabase vertebrate genome, repetitive DNA accounts for less one-sixth sequence, gene loci occupy about one-third genome. As with human are not evenly distributed, but clustered into sparse dense regions. Some “giant” genes were observed that had average coding sequence sizes spread genomic lengths significantly larger those their orthologs....
The recurring translocation t(11;16)(q23;p13.3) has been documented only in cases of acute leukemia or myelodysplasia secondary to therapy with drugs targeting DNA topoisomerase II. We show that the MLL gene is fused codes for CBP (CREB-binding protein), protein binds specifically DNA-binding CREB (cAMP response element-binding protein) this translocation. in-frame a different exon two patients producing chimeric proteins containing AT-hooks, methyltransferase homology domain, and...
Journal Article Analysis of the genomic sequence for autosomal dominant polycystic kidney disease (PKD1) gene predicts presence a leucine-rich repeat: The AMERICAN PKD1 Consortium (APKD1 Consortium) Get access Timothy C. Burn, Burn Search other works by this author on: Oxford Academic PubMed Google Scholar D. Connors, Connors William R. Dackowski, Dackowski Linda Petry, Petry Terence J. van Raay, Raay John M. Millholland, Millholland Marc Venet, Venet Glenn Miller, Miller Ramond Hakim, Hakim...
Bacillus anthracis, cereus, and thuringiensis are closely related gram-positive, spore-forming bacteria of the B. cereus sensu lato group. While independently derived strains anthracis reveal conspicuous sequence homogeneity, environmental isolates exhibit extensive genetic diversity. Here we report sequencing comparative analysis genomes two members group, 97-27 subsp. konkukian serotype H34, isolated from a necrotic human wound, E33L, which was swab zebra carcass in Namibia. These strains,...
BackgroundClostridium botulinum and related clostridial species express extremely potent neurotoxins known as (BoNTs) that cause long-lasting, potentially fatal intoxications in humans other mammals. The amino acid variation within the BoNT is used to categorize into seven immunologically distinct serotypes (A–G) which are further divided subtypes. BoNTs located two generally conserved gene arrangements progenitor complexes encode toxin-associated proteins involved toxin stability...
The growing potential of quantum dots (QDs) in applications as diverse biomedicine and energy has provoked much dialogue about their conceivable impact on human health the environment at large. Consequently, there been an urgent need to understand interaction with biological systems. Parameters such size, composition, surface charge, functionalization can be modified ways either enhance biocompatibility or reduce deleterious effects. In current study, we simultaneously compared alone...
We have identified a 26.5 kb gene-rich duplication shared by human Xq28 and 16p11.1. Complete comparative sequence analysis of cosmids from both loci has revealed identical 16p11.1 genomic structures for the creatine transporter gene (SLC6A8) five exons CDM (DXS1357E). Overall nucleotide similarity within was found to be 94.6%, suggesting that this interchromosomal occurred recent evolutionary time (7–10 mya). Based on comparisons between cDNA sequence, DXS1357E genes are transcriptionally...
A 9.7 kb segment encompassing exons 7-10 of the adrenoleukodystrophy (ALD) locus X chromosome has duplicated to specific locations near pericentromeric regions human chromosomes 2p11,10p11, 16p11 and 22q11. Comparative sequence analysis reveals 92-96% nucleotide identity, indicating that autosomal ALD paralogs arose relatively recently during course higher primate evolution (5-10 million years ago). Analysis sequences flanking duplication region identifies presence an unusual GCTTTTTGC...
The cellular protooncogene MYC encodes a nuclear transcription factor that is involved in regulating important functions, including cell cycle progression, differentiation, and apoptosis. Dysregulated expression appears critical to the development of various types malignancies, thus factors may also play key role pathogenesis certain cancers. We have cloned one such regulatory factor, termed CTCF, which highly evolutionarily conserved-11-zinc finger transcriptional possessing multiple DNA...
We have developed an approach for identifying overlapping cosmid clones by exploiting the high density of repetitive sequences in complex genomes. Individual are fingerprinted, using a combination restriction enzyme digestions followed hybridization with selected classes sequences. This "repeat fingerprinting" technique allows small regions clone overlap (10-20%) to be unambiguously assigned. demonstrate utility this approach, fingerprinting 3145 (1.25 x coverage), containing one or more...
Bacillus thuringiensis is an insect pathogen that widely used as a biopesticide (E. Schnepf, N. Crickmore, J. Van Rie, D. Lereclus, Baum, Feitelson, R. Zeigler, and H. Dean, Microbiol. Mol. Biol. Rev. 62:775-806, 1998). Here we report the finished, annotated genome sequence of B. Al Hakam, which was collected in Iraq by United Nations Special Commission (L. Radnedge, P. Agron, K. Hill, Jackson, L. Ticknor, Keim, G. Andersen, Appl. Environ. 69:2755-2764, 2003).