Astrid Terry
A5060548890- Genomics and Phylogenetic Studies
- Marine Ecology and Invasive Species
- Genomics and Chromatin Dynamics
- Parasite Biology and Host Interactions
- Protist diversity and phylogeny
- T-cell and Retrovirus Studies
- Microbial Community Ecology and Physiology
- Virus-based gene therapy research
- Chromosomal and Genetic Variations
- Cancer Mechanisms and Therapy
- Plant Pathogens and Fungal Diseases
- Plant Pathogens and Resistance
- Coral and Marine Ecosystems Studies
- Lymphoma Diagnosis and Treatment
- Marine Sponges and Natural Products
- Genomic variations and chromosomal abnormalities
- Biofuel production and bioconversion
- Acute Myeloid Leukemia Research
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Aquaculture disease management and microbiota
- vaccines and immunoinformatics approaches
- Microbial Metabolic Engineering and Bioproduction
- Algal biology and biofuel production
- Nuclear Structure and Function
University of Glasgow
1994-2016
Wellcome Centre for Molecular Parasitology
2016
Joint Genome Institute
2001-2012
Molecular Oncology (United States)
1996-2008
Centre National de la Recherche Scientifique
2007
Duke University
2007
University of Freiburg
2007
Lawrence Livermore National Laboratory
2007
Lawrence Berkeley National Laboratory
2006-2007
Kanazawa University
2007
We report the draft genome of black cottonwood tree, Populus trichocarpa . Integration shotgun sequence assembly with genetic mapping enabled chromosome-scale reconstruction genome. More than 45,000 putative protein-coding genes were identified. Analysis assembled revealed a whole-genome duplication event; about 8000 pairs duplicated from that event survived in A second, older is indistinguishably coincident divergence and Arabidopsis lineages. Nucleotide substitution, tandem gene...
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It model system for studying chloroplast-based photosynthesis, as well the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited common ancestor animals, but lost in plants. We sequenced ∼120-megabase nuclear genome performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated...
We report the draft genome sequence of model moss Physcomitrella patens and compare its features with those flowering plants, from which it is separated by more than 400 million years, unicellular aquatic algae. This comparison reveals genomic changes concomitant evolutionary movement to land, including a general increase in gene family complexity; loss genes associated environments (e.g., flagellar arms); acquisition for tolerating terrestrial stresses variation temperature water...
The first chordates appear in the fossil record at time of Cambrian explosion, nearly 550 million years ago. modern ascidian tadpole represents a plausible approximation to these ancestral chordates. To illuminate origins chordate and vertebrates, we generated draft protein-coding portion genome most studied ascidian, Ciona intestinalis . contains ∼16,000 genes, similar number other invertebrates, but only half that found vertebrates. Vertebrate gene families are typically simplified form ,...
Sea anemones are seemingly primitive animals that, along with corals, jellyfish, and hydras, constitute the oldest eumetazoan phylum, Cnidaria. Here, we report a comparative analysis of draft genome an emerging cnidarian model, starlet sea anemone Nematostella vectensis . The is complex, gene repertoire, exon-intron structure, large-scale linkage more similar to vertebrates than flies or nematodes, implying that ancestor was similarly complex. Nearly one-fifth inferred genes novelties, which...
Lancelets (‘amphioxus’) are the modern survivors of an ancient chordate lineage, with a fossil record dating back to Cambrian period. Here we describe structure and gene content highly polymorphic ∼520-megabase genome Florida lancelet Branchiostoma floridae, analyse it in context evolution. Whole-genome comparisons illuminate murky relationships among three groups (tunicates, lancelets vertebrates), allow not only reconstruction complement last common ancestor but also partial its genomic...
Trichoderma reesei is the main industrial source of cellulases and hemicellulases used to depolymerize biomass simple sugars that are converted chemical intermediates biofuels, such as ethanol. We assembled 89 scaffolds (sets ordered oriented contigs) generate 34 Mbp nearly contiguous T. genome sequence comprising 9,129 predicted gene models. Unexpectedly, considering utility effectiveness carbohydrate-active enzymes reesei, its encodes fewer than any other sequenced fungus able hydrolyze...
Draft genome sequences have been determined for the soybean pathogen Phytophthora sojae and sudden oak death ramorum. Oömycetes such as these species share kingdom Stramenopila with photosynthetic algae diatoms, presence of many genes probable phototroph origin supports a ancestry stramenopiles. Comparison two species' genomes reveals rapid expansion diversification protein families associated plant infection hydrolases, ABC transporters, toxins, proteinase inhibitors, and, in particular,...
The western clawed frog Xenopus tropicalis is an important model for vertebrate development that combines experimental advantages of the African laevis with more tractable genetics. Here we present a draft genome sequence assembly X. tropicalis. This encodes than 20,000 protein-coding genes, including orthologs at least 1700 human disease genes. Over 1 million expressed tags validated annotation. More one-third consists transposable elements, unusually prevalent DNA transposons. Like other...
Comparative analysis of the genomes one mollusc (Lottia gigantea) and two annelids (Capitella teleta Helobdella robusta) enable a more complete reconstruction genomic features last common ancestors protostomes, bilaterians metazoans; against this conserved background they provide first glimpse into lineage-specific evolution diversity lophotrochozoans. This paper presents draft genome sequences — freshwater leech (Helobdella bristly, segmented marine worm teleta) mollusc, owl limpet...
The multicellular green alga Volvox carteri and its morphologically diverse close relatives (the volvocine algae) are well suited for the investigation of evolution multicellularity development. We sequenced 138-mega-base pair genome V. compared approximately 14,500 predicted proteins to those unicellular relative Chlamydomonas reinhardtii. Despite fundamental differences in organismal complexity life history, two species have similar protein-coding potentials few species-specific gene...
Abstract Chlorella variabilis NC64A, a unicellular photosynthetic green alga (Trebouxiophyceae), is an intracellular photobiont of Paramecium bursaria and model system for studying virus/algal interactions. We sequenced its 46-Mb nuclear genome, revealing expansion protein families that could have participated in adaptation to symbiosis. NC64A exhibits variations GC content across genome correlate with global expression level, average intron size, codon usage bias. Although species been...
Harmful algal blooms (HABs) cause significant economic and ecological damage worldwide. Despite considerable efforts, a comprehensive understanding of the factors that promote these has been lacking, because biochemical pathways facilitate their dominance relative to other phytoplankton within specific environments have not identified. Here, biogeochemical measurements showed harmful alga Aureococcus anophagefferens outcompeted co-occurring in estuaries with elevated levels dissolved organic...
The til -1 locus was identified as a common retroviral integration site in virus-accelerated lymphomas of CD2- myc transgenic mice. We now show that viral insertions at lead to transcriptional activation PEBP2αA (CBFA1), transcription factor related the Drosophila segmentation gene product, Runt. Insertions are upstream and opposite orientation appear activate variant promoter is normally silent T cells. Activity this detected rodent osteogenic sarcoma cells primary osteoblasts, implicating...
To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes identified exons, regulatory elements, candidate that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, residing tandem familial clusters, differ extensively number,...
Abstract Background Scleractinian corals are the foundation of reef ecosystems in tropical marine environments. Their great success is due to interactions with endosymbiotic dinoflagellates ( Symbiodinium spp.), which they obligately symbiotic. To develop a for studying coral biology and symbiosis, we have constructed set cDNA libraries generated annotated ESTs from two species corals, Acropora palmata Montastraea faveolata . Results We 14,588 Ap ) 3,854 Mf high quality five life...
Endogenous feline leukemia virus (FeLV)-related sequences (enFeLV) are a family of proviral elements found in domestic cats and their close relatives. These can recombine with exogenous, infectious FeLVs subgroup A (FeLV-A), giving rise to host range variants FeLV-B. We that subset defective enFeLV proviruses is highly expressed lymphoma cell lines variety primary tissues, including lymphoid tissues from healthy specific-pathogen-free cats. At least two RNA species were detected, 4.5-kb...
The genetic basis of feline leukemia virus (FeLV)-induced lymphoma was investigated in a series 63 lymphoid tumors and tumor cell lines presumptive T-cell origin. These were examined for virus-induced rearrangements the c-myc, flvi-2 (bmi-1), fit-1, pim-1 loci, receptor (TCR) gene rearrangements, presence env recombinant FeLV (FeLV-B). myc locus most frequently affected naturally occurring lymphomas (32%; n = 38) either by transduction (21%) or proviral insertion (11%). Proviral insertions...