Kamel Jabbari
A5004252122- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Protist diversity and phylogeny
- Microbial Community Ecology and Physiology
- Diatoms and Algae Research
- Machine Learning in Bioinformatics
- RNA modifications and cancer
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Algal biology and biofuel production
- Genomic variations and chromosomal abnormalities
- Marine and coastal plant biology
- Epigenetics and DNA Methylation
- Photosynthetic Processes and Mechanisms
- DNA Repair Mechanisms
- Plant Virus Research Studies
- Seaweed-derived Bioactive Compounds
- Peanut Plant Research Studies
- Epilepsy research and treatment
- Trypanosoma species research and implications
- Phytoplasmas and Hemiptera pathogens
- Protein Structure and Dynamics
King Abdullah University of Science and Technology
2021
University of Cologne
2014-2019
Génomique Métabolique du Genoscope
2018
Max Planck Institute for Biology of Ageing
2016-2017
Centre National de la Recherche Scientifique
2004-2014
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2010-2014
Université d'Évry Val-d'Essonne
2013-2014
Centre National de Recherche en Génomique Humaine
2013-2014
Genoscope
2010-2014
École Normale Supérieure - PSL
2007-2013
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It model system for studying chloroplast-based photosynthesis, as well the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited common ancestor animals, but lost in plants. We sequenced ∼120-megabase nuclear genome performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated...
Oilseed rape (Brassica napus L.) was formed ~7500 years ago by hybridization between B. rapa and oleracea, followed chromosome doubling, a process known as allopolyploidy. Together with more ancient polyploidizations, this conferred an aggregate 72× genome multiplication since the origin of angiosperms high gene content. We examined consequences its recent duplication. The constituent An Cn subgenomes are engaged in subtle structural, functional, epigenetic cross-talk, abundant homeologous...
Diatoms, a type of microscopic marine and freshwater alga, dominate the oceans are responsible for about fifth primary productivity on Earth. The complete genome sequence Phaeodactylum tricornutum is reported in this issue, second diatom to be sequenced. Comparisons with Thalassiosira pseudonana, first, reveal that hundreds genes have been acquired by gene transfer from bacteria — or vice versa. Gene appears common during evolution, creating unorthodox combinations including some plants...
Bananas (Musa spp.), including dessert and cooking types, are giant perennial monocotyledonous herbs of the order Zingiberales, a sister group to well-studied Poales, which include cereals. vital for food security in many tropical subtropical countries most popular fruit industrialized countries. The Musa domestication process started some 7,000 years ago Southeast Asia. It involved hybridizations between diverse species subspecies, fostered by human migrations, selection diploid triploid...
The genome of Ectocarpus, a model organism for brown algae, has been sequenced. Brown algae are complex photosynthetic organisms that have adapted to life in rocky coastal environments. Genome analysis sheds light on this adaptation and reveals an extended set light-harvesting pigment biosynthesis genes novel metabolic processes such as halide metabolism. Comparative genomic analyses highlight the likely importance family receptor kinases related molecules evolution multicellularity plants,...
The green lineage is reportedly 1,500 million years old, evolving shortly after the endosymbiosis event that gave rise to early photosynthetic eukaryotes. In this study, we unveil complete genome sequence of an ancient member lineage, unicellular alga Ostreococcus tauri (Prasinophyceae). This cosmopolitan marine primary producer world's smallest free-living eukaryote known date. Features likely reflecting optimization environmentally relevant pathways, including resource acquisition, unusual...
Genome sequences of nine species citrus, including oranges, pummelos and mandarins, reveal pathways domestication provide resources for breeding. Cultivated citrus are selections from, or hybrids of, wild progenitor whose identities contributions to remain controversial. Here we sequence compare genomes—a high-quality reference haploid clementine genome mandarin, pummelo, sweet-orange sour-orange genomes—and show that cultivated types derive from two species. Although represent one species,...
The smallest known eukaryotes, at ≈1-μm diameter, are Ostreococcus tauri and related species of marine phytoplankton. genome lucimarinus has been completed compared with that O. . This comparison reveals surprising differences across orthologous chromosomes in the two from highly syntenic most cases to almost no similarity. Species divergence these phytoplankton is occurring through multiple mechanisms acting differently on different likely including acquisition new genes horizontal gene...
Red seaweeds are key components of coastal ecosystems and economically important as food a source gelling agents, but their genes genomes have received little attention. Here we report the sequencing 105-Mbp genome florideophyte Chondrus crispus (Irish moss) annotation 9,606 genes. The features an unusual structure characterized by gene-dense regions surrounded repeat-rich dominated transposable elements. Despite its fairly large size, this shows typical compact genomes, e.g., on average...
Recent studies reported DEPDC5 loss‐of‐function mutations in different focal epilepsy syndromes. Here we identified 1 predicted truncation and 2 missense 3 children with rolandic (3 of 207). In addition, families unclassified childhood epilepsies carrying truncating 82). The detected variants were all novel, inherited, present tested affected (n = 11) 7 unaffected family members, indicating low penetrance. Our findings extend the phenotypic spectrum associated suggest that epilepsy, albeit...
Diatoms are one of the most important constituents phytoplankton communities in aquatic environments, but spite this, only recently have large-scale diatom-sequencing projects been undertaken. With genome centric species Thalassiosira pseudonana available since mid-2004, accumulating sequence information for a pennate model appears natural subsequent aim. We generated over 12,000 expressed tags (ESTs) from diatom Phaeodactylum tricornutum, and upon assembly into nonredundant set, 5,108...
Transposable elements (TEs) are mobile DNA sequences present in the genomes of most organisms. They have been extensively studied animals, fungi, and plants, shown to important functions genome dynamics species evolution. Recent genomic data can now enlarge identification study TEs other branches eukaryotic tree life. Diatoms, which belong heterokont group, unicellular algae responsible for around 40% marine primary productivity. The a centric diatom, Thalassiosira pseudonana, pennate...
• By comparative analyses we identify lineage-specific diversity in transcription factors (TFs) from stramenopile (or heterokont) genome sequences. We compared a pennate (Phaeodactylum tricornutum) and centric diatom (Thalassiosira pseudonana) with those of other stramenopiles (oomycetes, Pelagophyceae, Phaeophyceae (Ectocarpus siliculosus)) as well to that Emiliania huxleyi, haptophyte is evolutionarily related the stramenopiles. provide detailed description TF complements report numerous...
Abstract Background Diatoms represent the predominant group of eukaryotic phytoplankton in oceans and are responsible for around 20% global photosynthesis. Two whole genome sequences now available. Notwithstanding, our knowledge diatom biology remains limited because only half their genes can be ascribed a function based onhomology-based methods. High throughput tools needed, therefore, to associate functions with diatom-specific genes. Results We have performed systematic analysis 130,000...
Members of the family Trypanosomatidae infect many organisms, including animals, plants and humans. Plant-infecting trypanosomes are grouped under single genus Phytomonas, failing to reflect wide biological pathological diversity these protists. While some Phytomonas spp. multiply in latex plants, or fruit seeds without apparent pathogenicity, others colonize phloem sap afflict substantial economic value, coffee tree, coconut oil palms. Plant have not been studied extensively at genome...
A recent investigation showed the existence of correlations between architectural features mammalian interphase chromosomes and compositional properties isochores. This result prompted us to compare maps Topologically Associating Domains (TADs) Lamina Associated (LADs) with corresponding isochore mouse human chromosomes. approach revealed that: 1) TADs LADs correspond isochores, i.e., isochores are genomic units that underlie chromatin domains; 2) conservation in genomes is explained by...
Diatoms are unicellular brown algae that likely arose from the endocytobiosis of a red alga into single‐celled heterotroph and constitute an algal class major importance in phytoplankton communities around globe. The first whole‐genome sequence diatom species, Thalassiosira pseudonana Hasle et Heimdal, was recently reported, features central to physiology ecology, such as silicon nitrogen metabolism, iron uptake, carbon concentration mechanisms, were described. Following this initial study,...
Abstract Currently, different sequencing platforms are used to generate plant genomes and no workflow has been properly developed optimize time, cost, assembly quality. We present LeafGo, a complete de novo genome workflow, that starts from tissue produces with modest laboratory bioinformatic resources in approximately 7 days using one long-read technology. LeafGo is optimized ten species, three of which high-quality chromosome-level assemblies without any scaffolding technologies. Finally,...
Next generation sequencing (NGS) has been a great success and is now standard method of research in the life sciences. With this technology, dozens whole genomes or hundreds exomes can be sequenced rather short time, producing huge amounts data. Complex bioinformatics analyses are required to turn these data into scientific findings. In order run fast, automated workflows implemented on high performance computers state art. While providing sufficient compute power storage meet NGS challenge,...