A5106079834- Genomics and Phylogenetic Studies
- Trypanosoma species research and implications
- Protist diversity and phylogeny
- Microbial Community Ecology and Physiology
- Biochemical and Molecular Research
- Research on Leishmaniasis Studies
- Fungal and yeast genetics research
- Yeasts and Rust Fungi Studies
- Parasitic Infections and Diagnostics
- Mycorrhizal Fungi and Plant Interactions
- RNA and protein synthesis mechanisms
- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- Toxin Mechanisms and Immunotoxins
- Chromosomal and Genetic Variations
- Marine and coastal plant biology
- Diatoms and Algae Research
- Bioinformatics and Genomic Networks
- Marine Ecology and Invasive Species
- Environmental DNA in Biodiversity Studies
- Congenital Ear and Nasal Anomalies
- Intramuscular injections and effects
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Vibrio bacteria research studies
Centre National de la Recherche Scientifique
2004-2022
Genoscope
2004-2022
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2008-2022
Génomique Métabolique du Genoscope
2004-2022
CEA Paris-Saclay
2019-2022
Université Paris-Saclay
2019-2022
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2020
Direction de la Recherche Fondamentale
2020
Université d'Évry Val-d'Essonne
2008-2017
Centre National de Recherche en Génomique Humaine
2013-2017
Diatoms, a type of microscopic marine and freshwater alga, dominate the oceans are responsible for about fifth primary productivity on Earth. The complete genome sequence Phaeodactylum tricornutum is reported in this issue, second diatom to be sequenced. Comparisons with Thalassiosira pseudonana, first, reveal that hundreds genes have been acquired by gene transfer from bacteria — or vice versa. Gene appears common during evolution, creating unorthodox combinations including some plants...
The duplication of entire genomes has long been recognized as having great potential for evolutionary novelties, but the mechanisms underlying their resolution through gene loss are poorly understood. Here we show that in unicellular eukaryote Paramecium tetraurelia, a ciliate, most nearly 40,000 genes arose at least three successive whole-genome duplications. Phylogenetic analysis indicates recent coincides with an explosion speciation events gave rise to P. aurelia complex 15 sibling...
The genome of the Périgord black truffle Tuber melanosporum Vittad., a gourmet delicacy that grows symbiotically on roots European oak, has been sequenced. This is largest and most complex fungal so far unusually gene-poor, but rich in mobile genetic elements known as transposons. Comparison with sequence Laccaria bicolor, another ectomycorrhizal symbiotic fungus, reveals contrasting gene sets reflecting two different molecular toolkits have evolved independently to fit root symbiont...
A double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance of a specific drug treatment in children indeterminate phase infection by Trypanosoma cruzi. Children were treated with benznidazole at dose 5 mg/kg/day for 60 days or placebo followed-up 48 months. The showed significant decrease geometric mean titers antibodies against T. cruzi measured indirect hemagglutination, immunofluorescence, ELISA. After four year follow-up, 62% benznidazole-treated no...
Red seaweeds are key components of coastal ecosystems and economically important as food a source gelling agents, but their genes genomes have received little attention. Here we report the sequencing 105-Mbp genome florideophyte Chondrus crispus (Irish moss) annotation 9,606 genes. The features an unusual structure characterized by gene-dense regions surrounded repeat-rich dominated transposable elements. Despite its fairly large size, this shows typical compact genomes, e.g., on average...
Abstract Background The dung-inhabiting ascomycete fungus Podospora anserina is a model used to study various aspects of eukaryotic and fungal biology, such as ageing, prions sexual development. Results We present 10X draft sequence P. genome, linked the sequences large expressed tag collection. Similar higher eukaryotes, transcription/splicing machinery generates numerous non-conventional transcripts. Comparison genome orthologous gene set with one its close relatives, Neurospora crassa ,...
Genomes of animals as different sponges and humans show conservation global architecture. Here we that multiple genomic features including transposon diversity, developmental gene repertoire, physical order, intron-exon organization are shattered in the tunicate Oikopleura, belonging to sister group vertebrates retaining chordate morphology. Ancestral architecture animal genomes can be deeply modified may therefore largely nonadaptive. This rapidly evolving lineage thus offers unique...
The parasitic marine dinoflagellate Amoebophrya is the first known eukaryote with aerobic mitochondria without a genome.
Abstract Background Dinoflagellates are aquatic protists particularly widespread in the oceans worldwide. Some responsible for toxic blooms while others live symbiotic relationships, either as mutualistic symbionts corals or parasites infecting other and animals. harbor atypically large genomes (~ 3 to 250 Gb), with gene organization expression patterns very different from closely related apicomplexan parasites. Here we sequenced analyzed of two early-diverging co-occurring parasitic...
Abstract Background Diatoms represent the predominant group of eukaryotic phytoplankton in oceans and are responsible for around 20% global photosynthesis. Two whole genome sequences now available. Notwithstanding, our knowledge diatom biology remains limited because only half their genes can be ascribed a function based onhomology-based methods. High throughput tools needed, therefore, to associate functions with diatom-specific genes. Results We have performed systematic analysis 130,000...
Members of the family Trypanosomatidae infect many organisms, including animals, plants and humans. Plant-infecting trypanosomes are grouped under single genus Phytomonas, failing to reflect wide biological pathological diversity these protists. While some Phytomonas spp. multiply in latex plants, or fruit seeds without apparent pathogenicity, others colonize phloem sap afflict substantial economic value, coffee tree, coconut oil palms. Plant have not been studied extensively at genome...
Species within the human pathogenic Cryptococcus species complex are major threats to public health, causing approximately 1 million annual infections globally. amylolentus is most closely known related of complex, and it non-pathogenic. Additionally, while have bipolar mating systems with a single large type (MAT) locus that represents derived state in Basidiomycetes, C. has tetrapolar system 2 MAT loci (P/R HD) located on different chromosomes. Thus, studying will shed light transition...
The numerous yeast genome sequences presently available provide a rich source of information for functional as well evolutionary genomics but unequally cover the large phylogenetic diversity extant yeasts. We present here complete sequence nuclear haploid-type strain Kuraishia capsulata (CBS1993T), nitrate-assimilating Saccharomycetales uncertain taxonomy, isolated from tunnels insect larvae underneath coniferous barks and characterized by its copious production extracellular...
Abstract As critical primary producers and recyclers of organic matter, the diversity marine protists has been extensively explored by high-throughput barcode sequencing. However, classification short metabarcoding sequences into traditional taxonomic units is not trivial, especially for lineages mainly known their genetic fingerprints. This case widespread Amoebophrya ceratii species complex, parasites dinoflagellate congeners. We used phenotypic characters, applied to 119 individuals...
We have performed a survey of the active genes in important human pathogen Trypanosoma cruzi by analyzing 5013 expressed sequence tags (ESTs) generated from normalized epimastigote cDNA library. Clustering all sequences resulted 771 clusters, comprising 54% ESTs. In total, ESTs corresponded to 3054 transcripts that might represent one-fourth total gene repertoire T. cruzi. About 33% showed similarity public databases, and large number hitherto undiscovered predicted be involved...
eLife digest Fungi are enigmatic organisms that flourish in soil, on decaying plants, or during infection of animals plants. Growing myriad forms, from single-celled yeast to multicellular molds and mushrooms, fungi have also evolved a variety strategies reproduce. Normally, reproduce one two ways: either they asexually, with individual producing new identical itself, sexually, individuals different ‘mating types’ contributing produce individual. However, some species exhibit ‘homothallism’...
Understanding factors that generate, maintain, and constrain host-parasite associations is of major interest to biologists. Although little studied, many extremely virulent micro-eukaryotic parasites infecting microalgae have been reported in the marine plankton. This case for Amoebophrya, a diverse highly widespread group Syndiniales potentially controlling dinoflagellates population. Here, we analyzed time-scale gene expression complete infection cycle two Amoebophrya strains same host...