A5009466377- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- SARS-CoV-2 detection and testing
- Bacteriophages and microbial interactions
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Probiotics and Fermented Foods
- Gut microbiota and health
- Bacillus and Francisella bacterial research
- Clostridium difficile and Clostridium perfringens research
- Enzyme Production and Characterization
- Biofuel production and bioconversion
University of Chicago
2023-2025
National Institutes of Health
2020
Virginia Tech
2019
We evaluated saliva (SAL) specimens for SARS-CoV-2 reverse transcriptase PCR (RT-PCR) testing by comparison of 459 prospectively paired nasopharyngeal (NP) or midturbinate (MT) swabs from 449 individuals with the aim using asymptomatic screening. Samples were collected in a drive-through car line symptomatic ( n = 380) and emergency department (ED) 69).
We evaluated saliva (SAL) specimens for SARS-CoV-2 RT-PCR testing by comparison of 459 prospectively paired nasopharyngeal (NP) or mid-turbinate (MT) swabs from 449 individuals with the aim using asymptomatic screening. Samples were collected in a drive-through car line symptomatic (N=380) and emergency department (ED) (N=69). The percent positive negative agreement compared to swab 81.1% (95% CI: 65.8% - 90.5%) 99.8% 98.7% 100%), respectively. sensitivity increased 90.0% 74.4% 96.5%) when...
Bacterial endospores can remain dormant and highly resistant to environmental insults for long periods but also rapidly germinate in response a nutrient-rich environment. The persistence subsequent germination of spores contribute their colonization new environments the spread certain diseases. Proteins Bacillus subtilis anthracis were identified that are associated with spore membrane, position allow them germination. A set proteins predicted carry out ion transport examined contributions...
Bacterial endospores can survive harsh environmental conditions and long-term dormancy in the absence of nutrients, but rapidly germinate under favorable conditions. In present study, we employed transposon sequencing (Tn-seq) to identify genes with previously uncharacterized roles spore germination. Identified that encoded inner membrane proteins were chosen for study defined mutants, which exhibited delayed germination several assays response varying germinants. Significantly slowed...
Abstract The human gut microbiome contains many bacterial strains of the same species (‘strain-level variants’). Describing in a biologically meaningful way rather than purely taxonomically is an important goal but challenging due to genetic complexity strain-level variation. Here, we measured patterns co-evolution across >7,000 spanning tree-of-life. Using these as prior for studying hundreds commensal that isolated, sequenced, and metabolically profiled revealed widespread structure...