All organisms store the information necessary to maintain life in their DNA. Any process that damages DNA, causing a loss or corruption of information, jeopardizes viability organism. One-electron oxidation is such process. In this Account, we address three central features one-electron DNA: (i) migration radical cation away from site its formation; (ii) electronic and structural factors determine nucleobases at which irreversible reactions most readily occur; (iii) mechanism reaction for...

Although luminescence spectroscopy has been a promising sensing technology with widespread applications in point-of-care diagnostics and chem-bio detection, it fundamentally suffers from low signal collection efficiency, considerable background noise, poor photostability, intrinsic omnidirectional emission properties. In this regard, surface plasmon-coupled emission, versatile plasmon-enhanced detection platform >50% high directionality, polarization previously explored to amplify the limit...

A series of cyanostilbene based D−π–A derivatives, comprising 6-(diethylamino)coumarin as a donor and benzene benzothiazole acceptors bridged by different π-spacers (benzene, thiophene), have been synthesized characterized. The influence π-spacer acceptor units on the photophysical, electrochemical, thermal properties dyes was investigated in detail. incorporation coumarin results significant increase fluorescence quantum yield. In solution phase, absorption emission dye TB show bathochromic...

Abstract Fluorescent organic materials that exhibit unique aggregation‐induced emission have been utilized for various applications, including white light (WLE). The typically rely on composite designs involving a mixture of compounds emitting at different wavelengths light. To overcome the limitations offered by design such mixtures, tremendous efforts were also emphasized in developing single‐molecule substrates emit either method is controlled solvent polarity, energy and charge transfer,...

The escalating concern about ohmic losses in metal-dependent plasmonics demands more effective material fabrication for the development of biosensing frameworks. omnidirectionality and low signal collection efficiency a conventional fluorescence-based detection platform make it challenging to realize better sensitivity real-time point-of-care diagnostics. In an attempt address these demands, recently photonic crystal-coupled emission (PCCE) has been demonstrated outperform well-established...

Combustion synthesized La2O3 and subsequently produced La(OH)3 are characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) Brunauer–Emmitt–Teller (BET) methods. The basicity of is utilized for Knoevenagel Hantzsch reactions. Reaction aldehydes with suitable substrates containing active methylene groups led to products in good excellent yields organic solvents, water under dry or solvent free conditions. Catalytic...

A series of α-cyanostilbenes substituted with dimethylaniline, diphenylaniline and carbazole was synthesized their optical spectroscopic properties in homogeneous solvents, the dioxane–water binary mixture solid state were investigated. Stilbenes (1 4) exhibit weak emission behavior solvents but show remarkable red-shifted along enhanced intensity water state. This phenomenon is due to aggregation induced effect. Other stilbenes also significant solvatochromic have similar characteristics...

The unique functionality of metallic and dielectric nanomaterials to generate intense electromagnetic field localization termed "hotspots" has been exploited in numerous luminescence-based biosensing applications. To obtain an amplified, sharply directional, polarized emission, tunable size shape morphologies have evaluated the surface plasmon-coupled emission (SPCE) platform. Although such studies significantly facilitated biosensor modalities, inevitable parasitic Ohmic losses...

The endoplasmic reticulum (ER) and lipid droplets (LDs) intricately interact in cellular processes, with the ER serving as a hub for synthesis LDs acting storage organelles lipids.

Abstract Breast cancer remains the second most common cause of cancer‐related deaths in women worldwide, with ≈70% cases linked to overexpression Estrogen Receptor (ERα). Existing imaging tools often fail reliably differentiate between ER‐positive and ER‐negative cells. To address this limitation, two novel fluorescent probes, E2N E2R , are synthesized by conjugating estradiol styryl rhodamine‐based fluorophores using click chemistry. These probes characterized their photophysical...

Room temperature multicomponent reactions (MCRs) are reported using Bi₂O₃, BiVO₄, and Bi₂WO₆ (nanoparticle) as heterogeneous catalysts. Among these, (5 mol%) nanoparticles showed excellent reactivity for the synthesis of functionalized dihydropyridine, polyhydroquinoline, 4<italic>H</italic>-chromene 2-amino-4<italic>H</italic>-benzo[<italic>b</italic>]pyran derivatives in aqueous medium.

Development of fluorescent probes enables the sensitive detection Fe 2+ at nanomolar levels with guided lipid droplet imaging is discussed.

1,4-Diphenylbutadiene compounds, namely 1-p-cyanophenyl-4-phenylbuta-1E,3E-diene (2), 1-p-nitrophenyl-4-phenylbuta-1E,3E-diene (3), 1-cyano-1,4-diphenylbuta-1Z,3E-diene (4), 1-p-cyanophenyl-4-p-nitrophenylbuta-1E,3E-diene (5), 1-cyano-1-p-nitrophenyl-4-phenylbuta-1Z,3E-diene (6), and 1-cyano-1-phenyl-4-p-nitrophenylbuta-1Z,3E-diene (7), have been synthesized their absorption fluorescence properties in organic solvents, water−dioxane, SDS, CTAB, Triton-X-100 micelles investigated. The...

Adsorption of all the reactants and order addition play a key role in synthesis 1,4-diazepines depicting possibility Langmuir–Hinshelwood mechanism.

One probe but two targets: viscous mitochondria to nucleolar staining.

We synthesized and characterized the photophysical properties of new non-charged merocyanines. Among them, MC-TB was shown to be a bright efficient fluorogenic molecular rotor able probe viscosity lipid droplets mitochondria.

A dicationic styrylpyridinium fluorophore for selective staining of mitochondria and investigation the associated physiological processes is described

An experimental investigation and theoretical study of the duplex DNA sequences d(5'-GAGG-3')· d(3'-CTCC-5') d(5'-GTGG-3')·d(3'-CACC-5') was carried out. The experiments show that efficiency radical cation transport, revealed by strand cleavage after treatment with piperidine, is same in both sequences. Density functional theory (DFT) calculations reveal essentially identical ionization potentials hole distributions for these when they are properly hydrated. effect hydration on electronic...

Reaction based rapid detection of trace quantities sulfite.

White-light-emitting diodes are energy efficiency replacement of conventional lighting sources. Herein, we report the luminescent behavior three simple cyanostilbenes with triphenylamine-donating groups bearing different electron-withdrawing (phenyl, pyridyl, and p-nitrophenyl) in a common donor (D)-π-acceptor (A) α-cyanostilbene construct along their thermal electrochemical properties. The density functional theory (DFT) studies reveal that aggregation-induced emission characteristic...

Aggregation propensity of pyridyl functionalized α-cyanostilbenes has been investigated with respect to various amino donors.