A5053713378- Surgical Sutures and Adhesives
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Facial Rejuvenation and Surgery Techniques
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Dermatologic Treatments and Research
- Sleep and Wakefulness Research
- Skin Protection and Aging
- Wound Healing and Treatments
- Biochemical effects in animals
- Reconstructive Facial Surgery Techniques
- Neuroendocrine regulation and behavior
- Dupuytren's Contracture and Treatments
- Facial Nerve Paralysis Treatment and Research
- Infant Health and Development
- Functional Brain Connectivity Studies
- Reconstructive Surgery and Microvascular Techniques
- Trigeminal Neuralgia and Treatments
- Cutaneous Melanoma Detection and Management
- Orthopedic Surgery and Rehabilitation
- Nonmelanoma Skin Cancer Studies
University of Pittsburgh
2023-2024
Center for the Neural Basis of Cognition
2023-2024
Kuchnir Dermatology & Dermatologic Surgery
2022-2024
Ochsner Medical Center
2023-2024
National Institute on Drug Abuse
2020-2022
National Institutes of Health
2020-2022
University of Guam
2022
Baylor University
2018
The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron activity. Stimulation medial (mPFC) neurons mice activated many downstream regions, as shown by fMRI. Axonal terminal stimulation mPFC including anteromedial thalamic nucleus (AM), reinforced behavior midbrain dopaminergic neurons. AM projecting also neurons, showed a positive-feedback loop organization. We found...
The supramammillary region (SuM) is a posterior hypothalamic structure, known to regulate hippocampal theta oscillations and arousal. However, recent studies reported that the stimulation of SuM neurons with neuroactive chemicals, including substances abuse, reinforcing. We conducted experiments elucidate how mediate such effects. Using optogenetics, we found excitation glutamatergic (GLU) was reinforcing in mice; this effect relayed by their projections septal GLU neurons. were active...
Cortical interneurons shape network activity in cell type-specific ways, and interact with other types. These interactions are understudied, as current methods typically restrict
Management of lower extremity wounds following successful tumor excision presents multiple challenges. Distal integument is highly prone to edema often lacks adequate skin laxity for standard primary closures. The closure must be resilient enough withstand mobility. As a result, optimal reconstruction may include grafting, rotational flaps, free tissue transfers, healing by second intention, or some combination. These methods involve steps in reconstruction, prolonged recovery period,...
BACKGROUND Reverse cutting needles are commonly used in cutaneous surgery due to their perceived ease of use. Despite this, there is limited research evaluating the force required puncture skin using contemporary needles. OBJECTIVE This study aims compare forces for two different needle geometries across various gauge sizes. MATERIALS AND METHODS The authors assessed necessary penetrate samples human abdominal taper three United States Pharmacopeia sizes with respective reverse counterparts....
BACKGROUND Surgeons face numerous choices in selecting sutures for skin closure, with potential adverse effects such as tissue tearing. OBJECTIVE To investigate the influence of needle design and suture gauge on tearing during suturing procedures. MATERIALS AND METHODS The authors tested tear-through force Newtons 3 types gauges using an artificial model a professional-grade tensiometer. Suture material was secured into model, applied to at constant rate, resulting Force–displacement...
Abstract How does the prefrontal cortex (PFC) regulate motivated behavior? Our experiments characterize circuits of PFC regulating motivation, reinforcement and dopamine activity, revealing a novel cortico-thalamic loop. The stimulation medial (mPFC) neurons activated many downstream regions, as shown by functional MRI. Axonal terminal mPFC in including anteromedial thalamic nucleus (AM), reinforced behavior midbrain dopaminergic neurons. AM projecting to also neurons, showed...
Abstract The supramammillary region (SuM) is a posterior hypothalamic structure, known to regulate hippocampal theta oscillations and arousal. However, recent studies reported that the stimulation of SuM neurons with neuroactive chemicals, including substances abuse, reinforcing. We conducted experiments illuminate how mediate such effects. excitation glutamatergic (GLU) was reinforcing in mice; this effect relayed by projections septal GLU neurons. were active during exploration approach...
indices to assess anxiety-related behavior (Kalueff et al., 2016).Dark light (DL) exploration is another common etiological model of that designed for mice (Eltokhi 2020).In our study, we used both tests confirm the level anxiety between C57BL/6 and DBA/2 strains in different housing conditions.Moreover, analyzed mouse's sera, which contained Neu5Ac Neu5Gc-sial-terminal(s) due
Cortical interneurons shape network activity in cell type-specific ways, and are also influenced by interactions with other types. These specific cell-type understudied, as transgenic labeling methods typically restrict to one neuron type at a time. Although recent have enabled post-hoc identification of types, these not available many labs. Here, we present method distinguish between two red fluorophores
The paramedian forehead flap (PMFF), based on the supratrochlear artery, is preferred technique for repairing large, deep nasal wounds, and secondary defect typically repaired by primary closure.1
Riopelle, Alexandria M. MD; Potter, Christian T. MSc; Schanbacher, Carl F. MD Author Information
Riopelle, Alexandria M. MD; Potter, Christian T. MSc; Schanbacher, Carl F. MD Author Information