A5092988894- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Parathyroid Disorders and Treatments
- Cellular transport and secretion
- IgG4-Related and Inflammatory Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Diabetes and associated disorders
- Protein Kinase Regulation and GTPase Signaling
- Vitamin C and Antioxidants Research
- Eosinophilic Disorders and Syndromes
- Peptidase Inhibition and Analysis
Instituto de Investigación Sanitaria Aragón
2021-2024
Hospital Clínico Universitario Lozano Blesa
2023-2024
Background: Countless confounding factors have been described in the interpretation of incidental myocardial uptakes. Among them, prostate cancer is probably most important. While some authors may defend benign etiology these uptakes, others propose a further study to rule out amyloid cardiomyopathy. Objective: Our aim investigate clinical relevance uptakes bone scans requested evaluate prostatic neoplasia, assessing possibility that correspond cardiac amyloidosis (CA). Methods:...
Amyloidosis is a heterogeneous group of diseases caused by abnormal extracellular deposition insoluble proteins and can involve myocardium. One the causes myocardial involvement TTR amyloidosis. Our objective has been to evaluate situation cardiac amyloidosis (CA) in our center role nuclear medicine, review state art medicine this entity.We have evaluated retrospectively 186 patients with clinical suspicion CA analyzed characteristics, free light chains immunofixation serum and/or urine,...
Cardiac involvement is common in amyloidosis, and the vast majority of cases amyloid cardiomyopathy are attributed to primary amyloidosis or transthyretin (ATTR). Although coexistence scintigraphy suggestive ATTR with monoclonal gammopathy undetermined significance well documented, correct diagnosis still challenging non-referral centers.We performed a retrospective study reviewing all diagnosed at our center over last 5 years, described experience diagnostic approach.During 74 patients...
Wild-type transthyretin (ATTRwt) amyloidosis is caused by the misfolding and deposition of protein (TTR) in absence mutations TTR gene. Studies regarding variant form ATTR (ATTRv) suggest that presence single-nucleotide polymorphisms (SNP) genes other than TTR, may influence development disease. However, genetic factors involved aetiopathogenesis ATTRwt are currently unknown. This work investigates sequence variants selected for their possible impact on amyloidosis. To do so, targeted...