A5073570932- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Immune cells in cancer
- Neutropenia and Cancer Infections
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Urologic and reproductive health conditions
- Radiopharmaceutical Chemistry and Applications
- Bone health and treatments
- Urinary Bladder and Prostate Research
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- Urological Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Chemotherapy-related skin toxicity
- Anorectal Disease Treatments and Outcomes
- Photodynamic Therapy Research Studies
- RNA Research and Splicing
Kanazawa University
2022-2025
Enfortumab vedotin (EV) is an established pharmacotherapy for metastatic urothelial carcinoma (mUC); however, its adverse events (AEs) cannot be overlooked. The study investigated the efficacy and safety of biweekly EV administration.
Intraoperative hypotension remains a serious adverse event of photodynamic diagnosis-assisted transurethral resection bladder tumor with oral administration 5-aminolevulinic acid. We conducted re-analysis perioperative in the acid to ascertain its safety.
Since 2020, the coronavirus disease 2019 pandemic has led to widespread practice of hand hygiene and wearing face masks, not only among medical personnel, but also general population. Thus, impact on incidence febrile neutropenia should be verified. This study aimed examine in hospitalized patients receiving chemotherapy at Kanazawa University Hospital. Among inpatients Department Urology chemotherapy, we compared between 317 cases 2018-2019 276 2020. We retrospectively analyzed factors via...
The detection of microsatellite instability in urologic cancers is rare, especially metastatic, castration-resistant prostate cancer with neuroendocrine differentiation.This a case 66-year-old Asian male patient adenocarcinoma who had metastases at initial presentation. Despite combined androgen deprivation therapy, his prostate-specific antigen (PSA) progressively increased, and re-biopsy revealed small cell carcinoma. He was treated platinum-based systemic chemotherapy, tumor markers,...
Abstract Objective Prostate-specific antigen is considered the most useful biomarker for prostate cancer, but not in all cases. In a previous study, we have shown that risk classification combining prostate-specific ≥100 ng/mL and chemokine (CC motif) ligand 2 ≥ 320 pg/mL can predict survivals. We investigated long-term usefulness of serum as complementary to developed novel system. Methods Serum samples were collected from 379 patients who underwent biopsy at Kanazawa University Hospital...
The suppression of androgen receptor (AR) expression exacerbates the migration potential prostate cancer. This study identified a previously unrecognized regulation AR-controlled pathway that promotes in cancer cells. Prostate cells pass through transwell membrane (mig cells) have higher with decreased AR than parental In this study, we aimed to elucidate mechanism enhancement associated signaling. Expression C-C motif ligand 20 (CCL20) is upregulated mig cells, unlike Knockdown small...
Bone is a common site of prostate cancer metastasis. turnover markers n-terminal propeptide type I procollagen (P1NP) and tartrate-resistant acid phosphatase 5b (TRACP-5b) are highly sensitive to bone remodeling activity. However, their prognostic significance as unknown. This study retrospectively examined the usefulness P1NP TRACP-5b biomarkers. Castration-resistant recurrence-free survival (CFS) was estimated using Kaplan–Meier method. A predictive model for CFS constructed multivariate...
Purpose: Prostate-specific antigen (PSA) is a useful prostate cancer (PC) biomarker, but some cases reported that PSA does not correlate with the Gleason score. Serum chemokine (CC motif) ligand 2 (CCL2) has been to be potential complementary it remains unclear whether can applied non-metastatic castration-sensitive (nmCSPC) or each section of stages. CCL2′s usefulness was investigated as prognostic nmCSPC biomarker in this study. Methods: samples were collected from 379 patients who...
The percentage of positive cores (PPC) is increasingly recognized as a prognostic factor in prostate cancer. However, the usefulness PPC for patients undergoing androgen deprivation therapy (ADT) and high-risk group has not been adequately studied.A retrospective analysis was conducted 255 who underwent biopsy (all-case group). We examined efficacy biomarker.Eighty-nine were treated with ADT alone (ADT group), 107 classified (high-risk median duration follow-up 112.4 months, 85.3 110.0...
Purpose To compare the prognosis and quality of life between radical cystectomy bladder conservative treatment for muscle invasive cancer in real world. Materials Methods Patients treated without metastases were retrospectively evaluated overall survival, progression‐free rehospitalization. Results Of 141 patients, 62 underwent 79 cystectomy. who had significantly better survival (HR: 1.83, 95% CI: 1.12–3.00; p < 0.01) 1.82, 0.99–3.34; = 0.03) than those treatment. However, there was no...
Objectives Patients with advanced cancer may develop bacterial infections (BI) as their general condition worsens, but blood tests often find it difficult to distinguish them from non-bacterial (NBI). The present prospective study was undertaken investigate the effectiveness of serum procalcitonin levels in distinguishing between BI and NBI patients urological cancer. Methods This prospectively evaluated diagnosed locally or metastatic recurrent our department September 2013 December 2019....
Abstract We focused on Tumor-Associated Macrophages (TAM) and explored its effects bladder cancer (BC). Co-culturing PMA-treated THP-1 with BC cell lines (UMUC3 T24) induced to develop suppressed CD68 increased CD206 expression which differentiated into M2-like macrophages. Co-culture of TAM this macrophage enhanced the migration invasive activities BC, as well EMT marker. Human cytokine antibody array conditioned medium from co-culture showed high CCL20, CCL2 CXCL7. qPCR revealed that these...
Despite treating advanced prostate cancer (PCa) with androgen deprivation therapy, it eventually progresses to castration-resistant PCa. Subsequently, taxanes are administered, but when PCa becomes resistant taxanes, another treatment is needed, which has not yet been established. We previously synthesized a novel α-trifluoromethyl chalcone, YS71, and reported its antitumor effects against cells. In this study, we confirmed efficacy androgen-sensitive, androgen-independent, taxane-resistant...
Introduction Recently, an absorbable hydrogel spacer is becoming more widespread to reduce rectal radiation dose for therapy localized prostate cancer. Case presentation A 79‐year‐old male patient was referred our hospital radical treatment of organ‐confined Low‐dose‐rate brachytherapy performed, and the injection added. The properly injected between rectum, causing no acute complications during hospitalization. Two months after low‐dose‐rate brachytherapy, visited with constipation melena,...
Abstract Background: The percentage of positive cores (PPC) is increasingly recognized as a prognostic factor in prostate cancer. However, the usefulness PPC for patients undergoing androgen deprivation therapy (ADT) and high-risk group has not been adequately studied. Methods: A retrospective analysis was conducted 255 who underwent biopsy (all-case group). We examined efficacy biomarker. Results: Eighty-nine were treated with ADT alone (ADT group), 107 classified (high-risk median duration...