A5075703460- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Pelvic floor disorders treatments
- Radiopharmaceutical Chemistry and Applications
- Immune cells in cancer
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Immune Cell Function and Interaction
- Bone health and treatments
- Nutrition and Health in Aging
- Urologic and reproductive health conditions
- Urinary Tract Infections Management
- Renal and related cancers
- Hormonal and reproductive studies
- Inflammatory Biomarkers in Disease Prognosis
Kanazawa University
2016-2025
Kanazawa University Hospital
2021
Nanjing Medical University
2019
Jiangsu Cancer Hospital
2019
Ishikawa Prefectural Central Hospital
2015
Previous studies have found that tumor-associated macrophages (TAMs) promote cancer progression. We previously reported TAMs prostate metastasis via activation of the CCL2-CCR2 axis. The CCR4 (receptor CCL17 and CCL22) expression level in breast was to be associated with lung metastasis. aim this study elucidate role CCR2 were expressed human cell lines tissues. In vitro co-culture cells resulted increased CCL2 levels cells. addition induced CCL22 production migration invasion enhanced...
Understanding the mechanism of lymph node metastasis, a poor prognostic sign for prostate cancer, and further dissemination disease is important to develop novel treatment strategies. Recent studies have reported that C‐C chemokine receptor 7 ( CCR 7), whose ligand CCL 21, abundantly expressed in metastasis promotes cancer progression. Tumor necrosis factor‐α TNF ‐α) chronically produced at low levels within tumor microenvironment. The aim this study was determine whether ‐α from metastatic...
To examine which preoperative factors, including urodynamic evaluations, and operative procedures could predict continence status after robot-assisted radical prostatectomy (RARP) in this study.Univariate multivariate logistic regression analyses of factors such as age, body mass index, prostate-specific antigen level before biopsy, prostate size surgery, membranous urethral length measured using magnetic resonance imaging (MRI), bladder compliance maximum closure pressure (MUCP) by study...
Understanding the mechanism of chemoresistance and disease progression in patients with prostate cancer is important for developing novel treatment strategies. In particular, resistance to cabazitaxel a major challenge docetaxel‐resistant castration‐resistant (CRPC) because often administered as last resort. However, by which develops still unclear. C‐C motif chemokine ligands (CCL) were shown contribute castration cells via an autocrine mechanism. Therefore, we focused on CCL key factors...
This study investigated tumor-associated macrophages activity in the microenvironment of renal cell carcinoma. Via a co-culture with macrophage-like cells differentiated from human monocyte line THP-1 and U937 cells, migration ability ACHN Caki-1 which are carcinoma was significantly increased, as epithelial-mesenchymal transition change. A chemokine array identified CCL20-CCR6 axis concentration-dependent signal migration. Akt activated by CCL20 neutralizing antibody suppressed ability,...
Background Coffee inhibits the progression of prostate cancer; however, direct mechanism through which coffee acts on cancer cells remains unclear. This study aimed to identify key compounds that possess anti‐cancer effects and investigate their mechanisms action. Methods The anti‐proliferation anti‐migration six potentially active types compounds, including kahweol acetate, cafestol, caffeine, caffeic acid, chlorogenic trigonelline hydrochloride, were evaluated using LNCaP, LNCaP‐SF, PC‐3,...
Abstract Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, multiple potential pharmacological actions both yet to be fully understood. This study therefore investigated effects acetate cafestol on human cancer ACHN Caki-1 cells. Accordingly, combination administration...
Once castration-resistant prostate cancer (CRPC) become resistant for cabazitaxel treatment, the patients are obliged to best supportive care. Therefore, elucidation of mechanism cabazitaxel-resistance and conquest important themes improve prognosis patients. Then we tried establish cabazitaxel-resistant CRPC cell lines characterized them. We established two lines, PC-3-TxR/CxR DU145-TxR/CxR from PC-3-TxR DU145-TxR previously established. cells became by 11.8-fold 4.4-fold, respectively. The...
Chemokines and their receptors have key roles in cancer progression. The present study investigated chemokine activity the prostate bone metastasis microenvironment. Growth migration of human cells were assayed cocultures with stromal cells. LNC aP significantly increased when co‐cultured isolated from metastases. Cytokine array analysis conditioned medium cell cultures identified CCL 5 as a concentration‐dependent promoter migration. was suppressed C‐C motif ligand ( 5) neutralizing...
Abstract Background Visceral metastasis (VM), an important poor prognostic factor of prostate cancer (PC), is not commonly observed in castration sensitive status but often after castration‐resistant progression. However, the site, timing emergence, and incidence VM patients have yet been fully elucidated. Methods Demographic, surgical, pathological, follow‐up data PC treated at Kanazawa University Hospital between January 2000 December 2016 were retrospectively analyzed using their medical...
Several markers that reflect inflammation and nutritional status have been associated with oncological outcomes in many tumors. This study aimed to describe the impact of pretreatment inflammatory indices on nonmetastatic renal cell carcinoma (RCC). A total 213 Japanese patients RCC at Kanazawa University Hospital between October 2007 December 2018 were included. The indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), C-reactive protein-to-albumin (CAR),...
Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) exhibits better postoperative urinary continence than conventional RARP (C-RARP) via the anterior approach. However, reasons behind this are unknown. Herein, early incontinence and anatomical differences of 51 propensity score-matched C-RARP RS-RARP cases were compared. Dynamic magnetic resonance imaging (MRI) was performed before after surgery to examine pelvic changes under abdominal pressure. The median urine loss ratios in...
This study aimed to investigate the postoperative urinary continence rate and incontinence types compared over time between conventional robot-assisted radical prostatectomy (C-RARP) Retzius-sparing RARP (RS-RARP).All 61 cases were selected from C-RARP RS-RARP by propensity score matching, pad scale, 24-h weight test, International consultation on questionnaire-short form (ICIQ-SF) followed-up up 12 months.The probability of per scale evaluation differed according how it was defined: months...
Retzius-sparing robot-assisted radical prostatectomy (RARP) has been reported to exhibit better postoperative urinary continence, but the reasons behind this are unknown. This study included 254 cases who underwent RARP and dynamic MRI. We measured urine loss ratio (ULR) immediately after urethral catheter removal investigated its affecting factors mechanisms. Nerve-sparing (NS) techniques was performed in 175 (69%) unilateral 34 (13%) bilateral cases, whereas 58 (23%) cases. The median ULR...
Neuroendocrine prostate cancer (NEPC) is rare and has a poor prognosis; its clinical course treatment outcomes are also unclear. This study investigated the characteristics, course, of patients with NEPC.This retrospective 14 histologically diagnosed NEPC at Kanazawa University Hospital between 2000 2019. Overall survival (OS) progression-free (PFS) were retrospectively analyzed using Kaplan-Meier method. Additionally, log-rank tests used to compare distributions.We included among 1,845...
Since 2020, the coronavirus disease 2019 pandemic has led to widespread practice of hand hygiene and wearing face masks, not only among medical personnel, but also general population. Thus, impact on incidence febrile neutropenia should be verified. This study aimed examine in hospitalized patients receiving chemotherapy at Kanazawa University Hospital. Among inpatients Department Urology chemotherapy, we compared between 317 cases 2018-2019 276 2020. We retrospectively analyzed factors via...
Advances in imaging technologies have increased the opportunities for treating small-diameter renal cell carcinomas (RCCs) elderly. This retrospective study based on real-world clinical practice compared perioperative complications, preoperative and postoperative function, recurrence-free survival, overall survival elderly patients with RCC who had undergone robot-assisted partial nephrectomy (RAPN) or percutaneous cryoablation (PCA). A total of 99 (aged ≥70 years), including 50 49 RAPN PCA...
The detection of microsatellite instability in urologic cancers is rare, especially metastatic, castration-resistant prostate cancer with neuroendocrine differentiation.This a case 66-year-old Asian male patient adenocarcinoma who had metastases at initial presentation. Despite combined androgen deprivation therapy, his prostate-specific antigen (PSA) progressively increased, and re-biopsy revealed small cell carcinoma. He was treated platinum-based systemic chemotherapy, tumor markers,...
To evaluate our initial experience with radium-223 chloride (Ra-223).A total of 26 castration-resistant prostate cancer (CRPC) patients bone metastases, treated Ra-223 at hospital were evaluated. This study aimed to observe adverse events (AEs) and changes in serum markers, Bone Scan Index (BSI). Additionally, the relationship between these values OS was investigated.The observed AEs mainly included fatigue nausea. Alkaline phosphatase (ALP) bone-type alkaline (BAP) levels decreased...