A5057812946- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary Bladder and Prostate Research
- Renal and related cancers
- Multiple Myeloma Research and Treatments
- Ureteral procedures and complications
- Urinary and Genital Oncology Studies
- Mass Spectrometry Techniques and Applications
- Urological Disorders and Treatments
- Extracellular vesicles in disease
- Hormonal and reproductive studies
- Testicular diseases and treatments
- Dialysis and Renal Disease Management
- Pelvic floor disorders treatments
- Pregnancy and Medication Impact
- Acute Kidney Injury Research
- Chemokine receptors and signaling
- Maternal and fetal healthcare
- Sarcoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Medical Imaging and Pathology Studies
- Cancer, Lipids, and Metabolism
Kanazawa University
2015-2021
Toyama Prefectural Central Hospital
2019
Kanazawa University Hospital
2016
Research Network (United States)
2015
Cerebral Palsy Research Network
2015
Isesaki Municipal Hospital
2011
Isesaki Fukushima Hospital
2011
Previous studies have found that tumor-associated macrophages (TAMs) promote cancer progression. We previously reported TAMs prostate metastasis via activation of the CCL2-CCR2 axis. The CCR4 (receptor CCL17 and CCL22) expression level in breast was to be associated with lung metastasis. aim this study elucidate role CCR2 were expressed human cell lines tissues. In vitro co-culture cells resulted increased CCL2 levels cells. addition induced CCL22 production migration invasion enhanced...
To examine which preoperative factors, including urodynamic evaluations, and operative procedures could predict continence status after robot-assisted radical prostatectomy (RARP) in this study.Univariate multivariate logistic regression analyses of factors such as age, body mass index, prostate-specific antigen level before biopsy, prostate size surgery, membranous urethral length measured using magnetic resonance imaging (MRI), bladder compliance maximum closure pressure (MUCP) by study...
Metastatic urothelial carcinoma is one of the most fatal urological malignancies. Cisplatin-based systemic chemotherapy standard treatment for metastatic carcinoma, and there little evidence to support metastasectomy. The aims study were evaluate efficacy metastasectomy investigate prognoses patients. included 436 patients with who treated at our hospital. Of these, we retrospectively analyzed 29 received curative primary tumor had been metastases. Seven these underwent In a multivariate...
Renal cell carcinoma (RCC) is one of the most fatal urological malignancies. Approximately 30% patients with RCC have metastasis at initial diagnosis and another after radical nephrectomy. Immunotherapy using interferon-α (IFN-α) interleukin-2 (IL-2) has been main treatment for metastatic (mRCC) patients, this therapy being still occasionally recommended. The aims study were to evaluate efficacy low-dose IL-2 investigate prognosis patients. Study subjects included 37 who clinically diagnosed...
To investigate how androgen-sensitive LNCaP cells crosstalk with androgen-insensitive DU145 or PC-3 cells.The numbers of were counted when co-cultured and vise versa. Androgen receptor (AR) activity in was examined by luciferase reporter assay after transfection a driven PSA promoter the presence cells. Concentration androgens medium measured liquid chromatography-mass spectrometry (LC-MS/MS). The ability migration invasion investigated using 2-layer chamber, cells.Co-culture resulted...
Background/Aim: A peripherally inserted central catheter (PICC) is recommended for the safe administration of anticancer agents. The effectiveness synthetic polymer-coated and non-coated PICCs was compared. Patients Methods: with advanced cancers who had indwelling were reviewed using their medical records. Three types compared in terms complications failure. Results: total 90 patients retrospectively analyzed, including 31 Groshong PICCs, 30 Argyle PICC kit, 29 kit II. incidence failure...
The tolerability of 2-weekly docetaxel at 25-35 mg/m2 for castration-resistant prostate cancer (CRPC) has not been fully evaluated. aim this study was to evaluate its compared 3-weekly 60-75 in patients with CRPC.In retrospective study, data were respect efficacy and safety between regimens CRPC.Time treatment failure prostate-specific antigen (PSA) response rate did differ significantly the two regimens. Compared administration, incidence severe leukopenia febrile neutropenia lower...
Urinary obstruction of the transplanted kidney caused by uterine leiomyoma is an extremely rare condition. To best our knowledge, there are only two reports in English literature. Psoas abscess secondary to renal graft pyelonephritis also uncommon. We present this unusual case and its treatment course. A 43-year-old female presented with dysfunction. She was started on peritoneal dialysis from age 26 years received transplantation her mother (living donor) at 27 years. Computed tomography...
Germ cell tumors with somatic‑type malignancy (GCTSTM) are rare, and patients GCTSTM have extremely poor prognoses a median survival of nine months. Somatic‑type malignancy, which mainly sarcomas, usually exhibit chemoresistance. The recommended therapy for is radical resection; however, Pazopanib, multityrosine kinase inhibitor, has indicated therapeutic effects some soft tissue sarcoma components. current study reports the case 21‑year‑old Asian man who presented after combined...
Abstract Background: The final treatment for castration-resistant prostate cancer (CRPC) is generally cabazitaxel treatment. However, once CRPC becomes resistant to cabazitaxel, the patients are obliged best supportive care. Therefore, elucidation of mechanism cabazitaxel-resistance and conquest important themes improve prognosis patients. We already established paclitaxel/docetaxel-resistant cancer, PC-3-TxR DU145-TxR cells, characterized those cell lines previously. Then we further tried...
Abstract [Background] The mechanisms that prostate cancer (PCa) progresses to castration-resistant PCa (CRPC) are adaptation and clonal selection. We hypothesized proliferated while each mechanism cooperated when recurred. [Materials Methods] After LNCaP cells were transfected with luciferase reporter driven by PSA promoter, cocultured androgen-insensitive DU145 or PC-3. Then DHEA DHT added the medium assay was performed. Also, we in measured various androgens level LC-MS/MS. As for...
Metanephric adenoma is an uncommon benign renal tumor that occurs predominantly in adult females and rarely children. Its histomorphology resembles of epithelial Wilms' papillary cell carcinoma. From a diagnostic therapeutic perspective, recognition this entity important as it has more favorable clinical outcome compared with should not be treated nephrectomy if the size small. However, preoperative diagnosis disease extremely challenging. The present study describes case rare disease, which...