A5009339367- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Corneal Surgery and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Corneal surgery and disorders
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Periodontal Regeneration and Treatments
- Titanium Alloys Microstructure and Properties
- Tissue Engineering and Regenerative Medicine
- Cell Adhesion Molecules Research
- Developmental Biology and Gene Regulation
- Cellular Mechanics and Interactions
- Nanoparticle-Based Drug Delivery
- Marine Ecology and Invasive Species
- Ocular Disorders and Treatments
- Polymer Surface Interaction Studies
- Ocular Surface and Contact Lens
Universitat Internacional de Catalunya
2019-2024
Institute for Bioengineering of Catalonia
2021
University of Miami
2020
Bioengineering Center
2019
Bone grafting is one of the most commonly performed treatments for bone healing or repair. Autografts, grafts from same patient, are frequently used because they can provide osteogenic cells and growth factors at site implant with reduced risk rejection transfer diseases. Nevertheless, this type graft presents some drawbacks, such as pain, infection, limited availability. For reason, synthetic among main proposals in regenerative medicine. This branch medicine based on development new...
The techniques used in oral implantology to remove bacterial biofilm from the surface of implants by machining titanium (implantoplasty) or placing rough dental through friction with cortical bone generate a large release particles. In this work, we performed simulation particle generation following clinical protocols. particles were characterized for commercially pure sizes 5, 10, 15, and 30 μm. aim was determine effect size chemical composition implant on immune response. For purpose,...
Abstract Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing smoothing dental implant surface. During implantoplasty there large release titanium metal particles might provoke proinflammatory response reduce viability osteogenic cells. We analyze inflammatory induced by Ti6Al4V released during as-received commercially pure Ti particles. Macrophages stimulated with obtained showed an increased expression TNF-α decreased TGF-β CD206....
Integrin selective peptidomimetics tune stem cell behavior<italic>in vitro</italic>and improve bone formation in rat calvarial defects.
Failure of corneal endothelium cell monolayer is the main cause leading to transplantation. Autologous cell-based therapies are required reconstruct in vitro monolayer. Several strategies have been proposed using embryonic stem cells and induced pluripotent cells, although their use has ethical issues as well limited clinical applications. For this purpose, we propose dental pulp isolated from third molars form We hypothesize that share an embryological origin with endothelial they both...
Surface topography and physical-chemical properties usually play a key-role in both osseointegration improvement bacterial colonization reduction over the surface of dental implants. The aim this study is to compare chemical bacteriological behavior two different acid passivation treatments on titanium c.p. grade 3 used for implant manufacturing. roughness was evaluated using White Light Interferometry (WLI) order determine parameters such as average (Sa), spacing parameter (Sm) hybrid index...
Biomimetic calcium-deficient hydroxyapatite (CDHA) as a bioactive material exhibits exceptional intrinsic osteoinductive and osteogenic properties because of its nanostructure composition, which promote favorable microenvironment. Its high reactivity has been hypothesized to play relevant role in the vivo performance, mediated by interaction with biological fluids, is amplified specific surface area. Paradoxically, this also behind vitro cytotoxicity material, especially pronounced static...
Implantoplasty is one of the most common techniques to remove peri-implantitis from surface dental implants. It a process mechanization titanium surface, causing loss roughness implant, which leads difficulty in tissue regeneration. The aim this research apply decontaminant based on citric acid and add collagen magnesium cations promote formation have bactericidal character. Eighty commercially pure grade 3 discs were used perform implantoplasty protocol, like clinics. They treated with four...
The placement of bone–level dental implants can lead to the detachment particles in surrounding tissues due friction with cortical bone. In this study, 60 were placed same design: 30 made commercially pure grade 4 titanium and Ti6Al4V alloy. These cow ribs following company’s protocols. Particles detached from isolated their size specific surface area characterized. irregular morphology was observed by scanning electron microscopy. Ion release medium determined at different immersion times...
One of the main problems in oral implantology today is peri-implantitis, which affects almost 20% dental implants placed patients. most commonly used techniques to eliminate bacterial biofilm implantoplasty, that consists mechanical modification implant surface topography followed by treatments with chemical reagents for decontamination. In this study, aim evaluate use two different based on hypochlorous acid (HClO) and hydrogen peroxide (H2O2). For purpose, 75 titanium grade 3 discs were...
Vascularization of large bone grafts is one the main challenges that limit clinical application tissue engineering (BTE). In this way, cell cocultures, which involve cross-talk between endothelial and osteogenic cells, have shown to be an effective strategy for in vitro prevascularization. Dental pulp represents easily accessible autologous source adult stem cells. A subset these named dental pluripotent-like cells (DPPSCs), shows high plasticity great capacity differentiate into different...
Abstract Background New tetragonal zirconia polycrystal dental implants stabilized with yttria (Y-TZP) have appeared in the implantology market form of single piece or two-piece zircona implant system. These new type improve aesthetical properties compared to conventional commercially pure (c.p.) titanium used for implants, although long term mechanical behavior these is not yet well known. In orthopaedics, application as femoral balls presented an important controversial use due premature...
Among the different layers of cornea, corneal endothelium, which is composed endothelial cells (CEC), plays a key role in maintenance cornea transparency. Based on donor shortages and limitations associated with transplantation, this work we have developed collagen hydrogels patterned structures surface to provide topographies ranges similar natural environment that CEC sense. This aimed at stimulating maintain typical phenotype alternatives transplantation. In sense, elaborated curved...
The machining of implants and parts for dental prostheses to eliminate biofilm in the implantoplasty process causes a loss mechanical properties also characteristics surfaces, making tissue regeneration difficult. In present work, treatments consisting elements that can reduce infection, such as citric acid magnesium, together with improve cell adhesion proliferation, collagen, are proposed implant–crown assembly. Titanium, zirconia, composite (PMMA + feldspar) cobalt–chromium discs were...
Abstract Background Failure of the corneal endothelium cell (CEC) monolayer is main cause leading to transplantation. Autologous cell-based therapies are required reconstruct in vitro monolayer. For this purpose, we propose use dental pulp stem cells isolated from third molars form CEC We hypothesize that by using (DPSC) share an embryological origin with CEC, as they both arise neural crest, may allow a direct differentiation process avoiding reprogramming techniques, such induced...