A5045490259- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Adsorption and biosorption for pollutant removal
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- TiO2 Photocatalysis and Solar Cells
- Synthetic Organic Chemistry Methods
- Advanced Photocatalysis Techniques
- Asymmetric Synthesis and Catalysis
- Electronic and Structural Properties of Oxides
- Catalysis for Biomass Conversion
- Water Quality Monitoring and Analysis
- Radical Photochemical Reactions
- Analytical chemistry methods development
- Chemical Synthesis and Analysis
- Mesoporous Materials and Catalysis
- Synthesis and Catalytic Reactions
- Organoboron and organosilicon chemistry
- Nanomaterials for catalytic reactions
- Phytochemical compounds biological activities
- Asymmetric Hydrogenation and Catalysis
- Stroke Rehabilitation and Recovery
- Gas Sensing Nanomaterials and Sensors
- Plant-derived Lignans Synthesis and Bioactivity
- Cyclopropane Reaction Mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Institute of Laboratory Animal Science
2024
State Key Laboratory of Molecular Reaction Dynamics
2014-2023
Chinese Academy of Sciences
2017-2023
Dalian Institute of Chemical Physics
2014-2023
Shanghai Institute of Organic Chemistry
2018-2023
Shanghai Jiao Tong University
2020-2023
XinHua Hospital
2022-2023
Kunming University of Science and Technology
2020-2023
Shanghai Cancer Institute
2023
Photoinduced water dissociation on rutile-TiO2 was investigated using various methods. Experimental results reveal that the occurs via transferring an H atom to a bridge bonded oxygen site and ejecting OH radical gas phase during irradiation. The reaction is strongly suppressed as coverage increases. Further scanning tunneling microscopy study demonstrates hydrogen bonds between molecules have dramatic effect reaction. Interestingly, single bond in dimer enhances reaction, while...
Highly enantioselective rhodium-catalyzed addition of arylboroxines to N-unprotected ketimines is realized for the first time by employing chiral BIBOP-type ligands with a Rh loading as low 1 mol %. A range α-trifluoromethyl-α,α-diaryl α-tertiary amines or 3-amino-3-aryloxindoles were formed excellent ee values and yields either WingPhos PFBO-BIBOP ligand. The method has enabled an efficient synthesis cipargamin.
Abstract An efficient asymmetric hydroesterfication of diarylmethyl carbinols is developed for the first time with a Pd‐WingPhos catalyst, resulting in series chiral 4‐aryl‐3,4‐dihydrocoumarins excellent enantioselectivities and good yields. The method features mild reaction conditions, broad substrate scope, use easily accessible starting materials, low palladium loadings. A plausible stereochemical model also proposed catalyst. This has enabled 4‐step synthesis ( R )‐tolterodine from...
Synthetic rubbers fabricated from 1,3-butadiene (BD) and its substituted monomers have been extensively used in tires, toughened plastics, many other products owing to the easy polymerization/copolymerization of these high stability resulting material manufacturing operations large-scale productions. The need for synthetic with increased environmental friendliness or endurance harsh environments has motivated remarkable progress synthesis BD recent years. We review developments an emphasis...
Abstract A sequential cross‐coupling/annulation of ortho ‐vinyl bromobenzenes with aromatic bromides was realized, providing a direct and modular approach to access polycyclic compounds. vinyl‐coordinated palladacycle proposed as the key intermediate for this process. Excellent chemoselectivity regioselectivity were observed in transformation. The practicability method is highlighted by its broad substrate scope, excellent functional group tolerance, rich transformations associated obtained products.
The Suzuki-Miyaura coupling is a fundamentally important transformation in modern organic synthesis. development of new reaction modes for chemical accessibility and higher synthetic efficiency still the consistent pursuance this field. An efficient enabled by controllable 1,4-palladium migration was realized to afford stereodefined multisubstituted olefins 1,3-dienes. exhibits remarkable broad substrate scope, excellent functional-group tolerance, versatile conversion with obtained...
Photocatalysis of a single methanol molecule on the TiO2(110) surface was investigated using high-resolution scanning tunneling microscopy (STM) technique. Three different types elementary photocatalytic processes, photodissociation, photoinduced migration formaldehyde, and formaldehyde photodesorption, were clearly observed. Detailed chemical structures intermediates obtained through careful comparisons between experimental STM images theoretical simulations based density functional theory...
Abstract The palladium catalyzed annulation of 1‐bromo‐2‐vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis substituted naphthalenes. A controllable aryl to vinylic 1,4‐palladium migration process is key success.
Chemical changes on methanol/TiO2(110) interface after UV illumination have been investigated by two-photon photoemission spectroscopy (2PPE) and scanning tunneling microscope (STM). Spontaneous recombination of the photocatalytic products, i.e., formaldehyde hydrogen atoms at bridging oxygen sites, has observed using 2PPE. In addition, tip induced also imaged STM, which further shows that can occur only when dissociation products stay in original sites. The experimental observation methanol...
A general synthesis of chiral α,α-diaryl carboxamides is developed by enantioselective cross-coupling between 2-bromo-2-aryl and arylboronic acids, leading to a series with various electronic properties functionalities in moderate excellent enantioselectivities yields. The employment sterically bulky P,P═O ligand L2 critical for the reactivity selectivity. This protocol applied an efficient asymmetric key intermediate dopamine receptor agonist SKF 38393.
Abstract Background Upper limb motor dysfunction is a common sequela of stroke, and its clinical efficacy needs to be improved. This protocol describes trial verify the robot-assisted virtual reality mirror therapy (RAVRMT) in improving upper stroke patients, explore central mechanism by using functional magnetic resonance imaging (fMRI). Methods will single-center, assessor-blinded, randomized controlled study. Thirty-two eligible patients randomly divided into 2 groups according ratio 1:1,...
Abstract An efficient asymmetric hydroesterfication of diarylmethyl carbinols is developed for the first time with a Pd‐WingPhos catalyst, resulting in series chiral 4‐aryl‐3,4‐dihydrocoumarins excellent enantioselectivities and good yields. The method features mild reaction conditions, broad substrate scope, use easily accessible starting materials, low palladium loadings. A plausible stereochemical model also proposed catalyst. This has enabled 4‐step synthesis ( R )‐tolterodine from...
Abstract Highly enantioselective rhodium‐catalyzed addition of arylboroxines to N‐unprotected ketimines is realized for the first time by employing chiral BIBOP‐type ligands with a Rh loading as low 1 mol %. A range α‐trifluoromethyl‐α,α‐diaryl α‐tertiary amines or 3‐amino‐3‐aryloxindoles were formed excellent ee values and yields either WingPhos PFBO‐BIBOP ligand. The method has enabled an efficient synthesis cipargamin.
Comprehensive Summary As the chemical industry grapples with need for more eco‐friendly practices, use of water as a reaction medium is gaining attraction in organic transformations. This mini‐review delves into Pd‐catalyzed reactions that utilize "on‐water" mechanism, spanning from 2019 to late 2023. These are neatly categorized several types: (A) Catalytic C—H activations, (B) Mizoroki‐ Heck‐type reactions, (C) Suzuki‐Miyaura and (D) Cyclization reactions. By showcasing potential...
We report a real-space imaging of formaldehyde (HCHO) adsorption on TiO2(110) surface probed by high-resolution scanning tunnelling microscopy (STM). Density functional theory calculations (DFT) were carried out to assign the observed features. The adsorptions occur exclusively 5-fold coordinated Ti (Ti5c) sites and oxygen vacancies (OVs). well-resolved configurations Ti5c feature overlapping two "dumbbell" structures which are originated from empty orbitals HCHO. STM images for physical...
An efficient and environmentally benign method for the preparation of substituted indene derivatives has been developed by using water as sole solvent. This reaction proceeded under air, tolerated a wide range functional-groups was easily scaled up. Bioactive natural products like indriline were synthesized via protocol. Preliminary results demonstrate that enantioselective variant can also be achieved.