A5024362933- Mast cells and histamine
- Neuropeptides and Animal Physiology
- Helicobacter pylori-related gastroenterology studies
- Receptor Mechanisms and Signaling
- Asthma and respiratory diseases
- Polyamine Metabolism and Applications
- Gastrointestinal motility and disorders
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nitric Oxide and Endothelin Effects
- Gastroesophageal reflux and treatments
- Inflammatory mediators and NSAID effects
- Amino Acid Enzymes and Metabolism
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Olfactory and Sensory Function Studies
- Organic and Inorganic Chemical Reactions
- Diet and metabolism studies
- Sulfur Compounds in Biology
- Food Allergy and Anaphylaxis Research
- Biochemical Analysis and Sensing Techniques
- Eicosanoids and Hypertension Pharmacology
- Adenosine and Purinergic Signaling
- Synthesis and Reactions of Organic Compounds
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
University of Parma
2004-2015
Tethys Research Institute
2010
McMaster University
2010
University of Turin
2000-2008
University of Edinburgh
2003
Mario Negri Institute for Pharmacological Research
2001
Institute of Pharmacology
1995-1999
Ospedale Maggiore
1995-1997
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
1995-1997
Ospedale di Parma
1995-1997
A new series of NSAIDs in which aspirin is joined by an ester linkage to furoxan moieties, with different ability release NO, were synthesized and tested for NO-releasing, antiinflammatory, antiaggregatory, ulcerogenic properties. Related furazan derivatives, aspirin, its propyl ester, γ-nitrooxypropyl taken as references. All the products described present antiinflammatory trend, maximized derivatives 12, 16, 17, they are devoid acute gastrotoxicity, principally due their nature, show...
A new series of nonsteroidal antiinflammatory drugs (NSAIDs) obtained by linking ibuprofen to selected furoxan moieties and related furazans were synthesized tested for their antiinflammatory, antiaggregatory, ulcerogenic properties. All the derivatives are endowed with activity comparable that ibuprofen, but, unlike this drug, they display reduced acute gastrotoxicity. The masking ibuprofen-free carboxylic group seems be principally at basis topical irritant action. two 8 9 also trigger...
A new class of products in which the phenol group salicylic acid is linked to alkanoyl moieties bearing nitrooxy functions has been synthesized and studied for their polyvalent actions. The were stable neutral media, while they hydrolyzed human serum. Their half-lives dependent upon structure moieties. showed anti-inflammatory activities similar aspirin when tested carrageenan-induced paw edema assay rat. Interestingly, unlike aspirin, reduced or no gastrotoxicity a lesion model rats at...
Abstract A series of water‐soluble (benzoyloxy)methyl esters acetylsalicylic acid (ASA), commonly known as aspirin, are described. The new derivatives each have alkyl chains containing a nitric oxide (NO)‐releasing nitrooxy group and solubilizing moiety bonded to the benzoyl ring. compounds were synthesized evaluated ASA prodrugs. After conversion appropriate salt, most solid at room temperature all possess good water solubility. They quite stable in solution (pH 1) less physiological pH. In...
This study examined the gastroprotective effect of (R)-α-methylhistamine (MHA), a selective agonist histamine H3receptors. Gastric lesions were induced in rat by administering absolute ethanol volume 1 ml. Stomachs removed h later and evaluated both macroscopically histologically. MHA dose-dependently inhibited ethanol-induced range 1-100 mg/kg intragastric intraperitoneal route. Histological findings indicated that number mucous granules surface neck cells was increased process...
Nociceptin (N/OFQ) exerts multiple effects in the gastrointestinal tract after central or peripheral administration. In present study, we examined possible mechanisms mediating gastric protection by N/OFQ rats. Gastric mucosal lesions were induced 50% ethanol (1 ml/rat intragastrically). N/OFQ, administered either intracerebroventricularly (3 microg/rat) ip (10 microg/kg), significantly reduced macroscopic and histological damage. The protective effect of intracerebroventricular was blocked...
The histamine H3 receptor (H3R) has been identified in the gastrointestinal tract of rat by immunohistochemistry, using first validated anti-H3 antibody. Immunoreactivity to H3R was exclusively localized endocrine cells scattered mucosa, with positive being prominently abundant gastric fundus, while they were rarely found other regions. In distributed lower half mucosa and their number significantly decreased after a 24 h-fasting period. Double-labeling studies undertaken identify...
1. (R)-alpha-methylhistamine, a selective agonist of histamine H(3) receptors, promotes mucus secretion and increases the number volume mucus-secreting cells. The hypothesis that increased mucous cells could reside in an alteration homeostasis gastric epithelium was investigated. 2. (R)-alpha-methylhistamine administered to rats 1 h (10-100 mg kg(-1) by intragastric intraperitoneal route) 24 (100 prior killing. (S)-isomer alpha-methylhistamine (55.4 kg(-1)), 100 times less potent than...
The maintenance of gastric mucosal integrity is ensured by a dynamic balance between protective and noxious factors. mucosa has multiple mechanisms that allow the to withstand frequent exposure potentially damaging agents such as acid peptic secretions, bacterial products, ingested food, alcoholic beverages, certain drugs. imbalance defensive aggressive factors at basis formation erosions/lesions or ulcerations mucosa. difference an erosion/lesion ulceration former confined mucosa, while...